ID   BRE4_ASHGO              Reviewed;        1053 AA.
AC   Q75E41;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Protein BRE4;
GN   Name=BRE4; OrderedLocusNames=ABL171W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 204 AND 257-258.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: May be involved in intracellular vesicle transport.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BRE4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016815; AAS50600.2; -; Genomic_DNA.
DR   RefSeq; NP_982776.2; NM_208129.2.
DR   AlphaFoldDB; Q75E41; -.
DR   SMR; Q75E41; -.
DR   STRING; 284811.Q75E41; -.
DR   EnsemblFungi; AAS50600; AAS50600; AGOS_ABL171W.
DR   GeneID; 4618856; -.
DR   KEGG; ago:AGOS_ABL171W; -.
DR   eggNOG; KOG4711; Eukaryota.
DR   HOGENOM; CLU_004486_0_0_1; -.
DR   InParanoid; Q75E41; -.
DR   OMA; FWGWAAN; -.
DR   Proteomes; UP000000591; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006897; P:endocytosis; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR023244; Brefeldin_A-sensitivity_4.
DR   PRINTS; PR02047; BREFELDNASP4.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1053
FT                   /note="Protein BRE4"
FT                   /id="PRO_0000239633"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        661..681
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        735..755
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        760..780
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        794..814
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          991..1014
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        464
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        469
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        547
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        647
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        701
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1003
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1053 AA;  119045 MW;  DB0E289904773BD6 CRC64;
     MEVLKGSYKQ KSFQSLKDLG QQGSSAAPGV RPTKSLQTSP IGSWTSLSHL RLEKLAEGSG
     WEELQDYGLE ELRDGFFDAS YSRPQRVAAT EPPVSTSPKA QSPLAVRCKA FRDRLRVHWK
     AVVKFTVAYL AAMFLCLVRP ASDWIGDVYS CFLPVAVLIH HPVRTVGVQL EITVQSIVGL
     ALGQGWSALW WYVCSVARVG RHEGALLFLS LVLSGLWSSW LAAAYGRLVY MSVSFGITAT
     FFATSMPPSE GSLPIWRHFW DQGMSYLFGL LLSLLVCIFL FPRFGHATIG RGFSSAANDL
     KHLLDYLVDA RYCNDIPMLV EAQENAVSAI DVRLSEGYRE FANQFSITRF DGKLLEQLRN
     SLTIAASPLR SLPLGHGLLT NVELERFHQA RPQSAPENTI CVRDADDHYE DQAIKTEESA
     NLGLACGSTD LCSAIIRDKF SETIFDLIME LIHALNSLQV GLNNISESNV SASERADIKA
     NILACLSNLH DRIRRLDIKY KEFGRAGLFT SELLLNPKSS DALVFLRYIR QCAKHMTKVL
     EVFLQLNASV HWRVIPPKYQ WHRAIHRLSH QCALDQGASF LWNYFQTKRD VDDAFEMIYN
     SYTSKHHEVS DLFSRQGMRP RIRAFDHKDF AVHSTSNPIR YKLWQLNNSL LGPESRWARK
     FTVVLVALCL PGWLPGSKVW YREYHCLWAP IIYVILSNRR NSSNWRALYK RLAGCVLGVF
     WAWCANQAKH YSNPFIIATF SVLLCIPLAF NYFAYNRRKS TLAALICFTV PALVTFFLEE
     HTTASLWKQA WTTGVALLIG TFCSIPINWF IWTFTARSEL SLAVSGLLMH LSQSYQIVAG
     RYLYRDTDDH PNDLTRSLAS IREVRLSQSL LATRALVRSA VSEPNIVSEF RAYLFDELLD
     HFSVLLERLI EARRLGQHFQ VWDRDPNTET TRALLSLRRD NVASVIFIFY MLSNCFSSGS
     KVPKYLPNPI FVRKKLFDTF MKLAEDASAR GTSAHSSTPA APNNTDPSSP SSAGQDHWDE
     VYAICFSRAF TDISVELQRI IDLAKEILGQ EGD