TGRM1_HUMAN
ID TGRM1_HUMAN Reviewed; 1720 AA.
AC Q9Y4F4; Q68D66; Q6PG27;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 4.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=TOG array regulator of axonemal microtubules protein 1 {ECO:0000312|HGNC:HGNC:19959};
DE AltName: Full=Crescerin-1 {ECO:0000305};
DE AltName: Full=Protein FAM179B;
GN Name=TOGARAM1 {ECO:0000312|HGNC:HGNC:19959}; Synonyms=FAM179B, KIAA0423;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9455477; DOI=10.1093/dnares/4.5.307;
RA Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. VIII. 78
RT new cDNA clones from brain which code for large proteins in vitro.";
RL DNA Res. 4:307-313(1997).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Hippocampus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=16335990; DOI=10.1021/pr050133p;
RA Hepner F., Myung J.-K., Ulfig N., Pollak A., Lubec G.;
RT "Detection of hypothetical proteins in human fetal perireticular nucleus.";
RL J. Proteome Res. 4:2379-2385(2005).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ARMC9; CCDC66; CEP104 AND
RP CSPP1, INVOLVEMENT IN JBTS37, VARIANTS JBTS37 362-GLN--LEU-1720 DEL;
RP TRP-368; ASP-371; PRO-375; 1083-SER--LEU-1720 DEL; CYS-1311 AND
RP 1675-ARG--LEU-1720 DEL, AND CHARACTERIZATION OF VARIANTS JBTS37 TRP-368;
RP PRO-375 AND CYS-1311.
RX PubMed=32453716; DOI=10.1172/jci131656;
RG University of Washington Center for Mendelian Genomics;
RG Genomics England Research Consortium;
RA Latour B.L., Van De Weghe J.C., Rusterholz T.D., Letteboer S.J., Gomez A.,
RA Shaheen R., Gesemann M., Karamzade A., Asadollahi M., Barroso-Gil M.,
RA Chitre M., Grout M.E., van Reeuwijk J., van Beersum S.E., Miller C.V.,
RA Dempsey J.C., Morsy H., Bamshad M.J., Nickerson D.A., Neuhauss S.C.,
RA Boldt K., Ueffing M., Keramatipour M., Sayer J.A., Alkuraya F.S.,
RA Bachmann-Gagescu R., Roepman R., Doherty D.;
RT "Dysfunction of the ciliary ARMC9/TOGARAM1 protein module causes Joubert
RT syndrome.";
RL J. Clin. Invest. 130:4423-4439(2020).
RN [9]
RP INVOLVEMENT IN JBTS37, AND VARIANTS JBTS37 TRP-368 AND 1207-ARG--LEU-1720
RP DEL.
RX PubMed=32747439; DOI=10.1136/jmedgenet-2020-106833;
RA Morbidoni V., Agolini E., Slep K.C., Pannone L., Zuccarello D., Cassina M.,
RA Grosso E., Gai G., Salviati L., Dallapiccola B., Novelli A., Martinelli S.,
RA Trevisson E.;
RT "Biallelic mutations in the TOGARAM1 gene cause a novel primary
RT ciliopathy.";
RL J. Med. Genet. 58:526-533(2021).
CC -!- FUNCTION: Involved in ciliogenesis (PubMed:32453716). It is required
CC for appropriate acetylation and polyglutamylation of ciliary
CC microtubules, and regulation of cilium length (PubMed:32453716).
CC Interacts with microtubules and promotes microtubule polymerization via
CC its HEAT repeat domains, especially those in TOG region 2 and 4 (By
CC similarity). {ECO:0000250|UniProtKB:Q17423,
CC ECO:0000250|UniProtKB:Q6A070, ECO:0000269|PubMed:32453716}.
CC -!- SUBUNIT: Interacts with ARMC9, CCDC66, CEP104 and CSPP1.
CC {ECO:0000269|PubMed:32453716}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q6A070}. Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q6A070}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:32453716}. Note=Detected along the length of
CC primary cilia and at the basal body. Colocalization with the
CC cytoplasmic microtubule cytoskeleton upon heterologous expression is
CC most likely an artifact. {ECO:0000250|UniProtKB:Q6A070}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9Y4F4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y4F4-2; Sequence=VSP_020822, VSP_020823;
CC Name=3;
CC IsoId=Q9Y4F4-3; Sequence=VSP_020821, VSP_020824;
CC -!- DOMAIN: The TOG regions are composed of HEAT-type repeats that assemble
CC into a solenoid structure. They mediate interaction with microtubules.
CC {ECO:0000250|UniProtKB:Q6A070}.
CC -!- DISEASE: Joubert syndrome 37 (JBTS37) [MIM:619185]: A form of Joubert
CC syndrome, a disorder presenting with cerebellar ataxia, oculomotor
CC apraxia, hypotonia, neonatal breathing abnormalities and psychomotor
CC delay. Neuroradiologically, it is characterized by cerebellar vermian
CC hypoplasia/aplasia, thickened and reoriented superior cerebellar
CC peduncles, and an abnormally large interpeduncular fossa, giving the
CC appearance of a molar tooth on transaxial slices (molar tooth sign).
CC Additional variable features include retinal dystrophy, renal disease,
CC liver fibrosis, and polydactyly. JBTS37 inheritance is autosomal
CC recessive. {ECO:0000269|PubMed:32453716, ECO:0000269|PubMed:32747439}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry.
CC -!- SIMILARITY: Belongs to the Crescerin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA24853.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAH18354.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB007883; BAA24853.2; ALT_INIT; mRNA.
DR EMBL; CR749557; CAH18354.1; ALT_FRAME; mRNA.
DR EMBL; AL049870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL121809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057255; AAH57255.1; -; mRNA.
DR CCDS; CCDS9681.1; -. [Q9Y4F4-1]
DR PIR; T00057; T00057.
DR RefSeq; NP_055906.2; NM_015091.3. [Q9Y4F4-1]
DR RefSeq; XP_016876589.1; XM_017021100.1. [Q9Y4F4-3]
DR AlphaFoldDB; Q9Y4F4; -.
DR SMR; Q9Y4F4; -.
DR BioGRID; 116738; 9.
DR IntAct; Q9Y4F4; 6.
DR STRING; 9606.ENSP00000355045; -.
DR iPTMnet; Q9Y4F4; -.
DR PhosphoSitePlus; Q9Y4F4; -.
DR BioMuta; TOGARAM1; -.
DR DMDM; 296439476; -.
DR jPOST; Q9Y4F4; -.
DR MassIVE; Q9Y4F4; -.
DR PaxDb; Q9Y4F4; -.
DR PeptideAtlas; Q9Y4F4; -.
DR PRIDE; Q9Y4F4; -.
DR ProteomicsDB; 86194; -. [Q9Y4F4-1]
DR ProteomicsDB; 86195; -. [Q9Y4F4-2]
DR ProteomicsDB; 86196; -. [Q9Y4F4-3]
DR Antibodypedia; 23425; 13 antibodies from 6 providers.
DR DNASU; 23116; -.
DR Ensembl; ENST00000361577.7; ENSP00000355045.3; ENSG00000198718.13. [Q9Y4F4-1]
DR Ensembl; ENST00000557423.5; ENSP00000451829.1; ENSG00000198718.13. [Q9Y4F4-3]
DR GeneID; 23116; -.
DR KEGG; hsa:23116; -.
DR UCSC; uc001wvv.4; human. [Q9Y4F4-1]
DR CTD; 23116; -.
DR DisGeNET; 23116; -.
DR GeneCards; TOGARAM1; -.
DR HGNC; HGNC:19959; TOGARAM1.
DR HPA; ENSG00000198718; Low tissue specificity.
DR MalaCards; TOGARAM1; -.
DR MIM; 617618; gene.
DR MIM; 619185; phenotype.
DR neXtProt; NX_Q9Y4F4; -.
DR OpenTargets; ENSG00000198718; -.
DR PharmGKB; PA162387516; -.
DR VEuPathDB; HostDB:ENSG00000198718; -.
DR eggNOG; KOG2933; Eukaryota.
DR GeneTree; ENSGT00940000158712; -.
DR HOGENOM; CLU_275329_0_0_1; -.
DR InParanoid; Q9Y4F4; -.
DR PhylomeDB; Q9Y4F4; -.
DR TreeFam; TF315518; -.
DR PathwayCommons; Q9Y4F4; -.
DR SignaLink; Q9Y4F4; -.
DR BioGRID-ORCS; 23116; 12 hits in 1073 CRISPR screens.
DR ChiTaRS; FAM179B; human.
DR GenomeRNAi; 23116; -.
DR Pharos; Q9Y4F4; Tdark.
DR PRO; PR:Q9Y4F4; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9Y4F4; protein.
DR Bgee; ENSG00000198718; Expressed in bronchial epithelial cell and 205 other tissues.
DR ExpressionAtlas; Q9Y4F4; baseline and differential.
DR Genevisible; Q9Y4F4; HS.
DR GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR GO; GO:1905515; P:non-motile cilium assembly; ISS:UniProtKB.
DR GO; GO:0031116; P:positive regulation of microtubule polymerization; ISS:UniProtKB.
DR Gene3D; 1.25.10.10; -; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR028401; Crescerin-1.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR21567:SF6; PTHR21567:SF6; 3.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Ciliopathy;
KW Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton; Disease variant;
KW Joubert syndrome; Reference proteome; Repeat.
FT CHAIN 1..1720
FT /note="TOG array regulator of axonemal microtubules protein
FT 1"
FT /id="PRO_0000251952"
FT REPEAT 175..212
FT /note="HEAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 214..247
FT /note="HEAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 251..289
FT /note="HEAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 345..384
FT /note="HEAT 4"
FT /evidence="ECO:0000255"
FT REPEAT 390..427
FT /note="HEAT 5"
FT /evidence="ECO:0000255"
FT REPEAT 431..466
FT /note="HEAT 6"
FT /evidence="ECO:0000255"
FT REPEAT 467..504
FT /note="HEAT 7"
FT /evidence="ECO:0000255"
FT REPEAT 506..543
FT /note="HEAT 8"
FT /evidence="ECO:0000255"
FT REPEAT 1294..1331
FT /note="HEAT 9"
FT /evidence="ECO:0000255"
FT REPEAT 1335..1372
FT /note="HEAT 10"
FT /evidence="ECO:0000255"
FT REPEAT 1485..1522
FT /note="HEAT 11"
FT /evidence="ECO:0000255"
FT REPEAT 1526..1563
FT /note="HEAT 12"
FT /evidence="ECO:0000255"
FT REPEAT 1567..1605
FT /note="HEAT 13"
FT /evidence="ECO:0000255"
FT REGION 94..312
FT /note="TOG 1"
FT /evidence="ECO:0000250|UniProtKB:Q6A070"
FT REGION 352..596
FT /note="TOG 2"
FT /evidence="ECO:0000250|UniProtKB:Q6A070"
FT REGION 794..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1067..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1256..1425
FT /note="TOG 3"
FT /evidence="ECO:0000250|UniProtKB:Q6A070"
FT REGION 1430..1462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1484..1720
FT /note="TOG 4"
FT /evidence="ECO:0000250|UniProtKB:Q6A070"
FT COMPBIAS 794..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1087
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 969..995
FT /note="MHSSLRSLRNSAAKKRAKLSGSTSDLE -> VRHISNIWVKTLSNKTFFCKE
FT KNFSYC (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_020821"
FT VAR_SEQ 969..974
FT /note="MHSSLR -> VRTKYF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020822"
FT VAR_SEQ 975..1720
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020823"
FT VAR_SEQ 996..1720
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_020824"
FT VARIANT 362..1720
FT /note="Missing (in JBTS37)"
FT /evidence="ECO:0000269|PubMed:32453716"
FT /id="VAR_085345"
FT VARIANT 368
FT /note="R -> W (in JBTS37; loss of interaction with ARMC9)"
FT /evidence="ECO:0000269|PubMed:32453716,
FT ECO:0000269|PubMed:32747439"
FT /id="VAR_085346"
FT VARIANT 371
FT /note="A -> D (in JBTS37; unknown pathological
FT significance; dbSNP:rs370676288)"
FT /evidence="ECO:0000269|PubMed:32453716"
FT /id="VAR_085347"
FT VARIANT 375
FT /note="L -> P (in JBTS37; loss of interaction with ARMC9;
FT dbSNP:rs150433582)"
FT /evidence="ECO:0000269|PubMed:32453716"
FT /id="VAR_085348"
FT VARIANT 416
FT /note="E -> Q (in dbSNP:rs3825629)"
FT /id="VAR_027739"
FT VARIANT 511
FT /note="L -> V (in dbSNP:rs3742591)"
FT /id="VAR_027740"
FT VARIANT 1083..1720
FT /note="Missing (in JBTS37)"
FT /evidence="ECO:0000269|PubMed:32453716"
FT /id="VAR_085349"
FT VARIANT 1207..1720
FT /note="Missing (in JBTS37)"
FT /evidence="ECO:0000269|PubMed:32747439"
FT /id="VAR_085350"
FT VARIANT 1311
FT /note="R -> C (in JBTS37; affects ciliogenesis resulting in
FT shorter cilia; does not affect the interaction with ARMC9;
FT dbSNP:rs759684383)"
FT /evidence="ECO:0000269|PubMed:32453716"
FT /id="VAR_085351"
FT VARIANT 1675..1720
FT /note="Missing (in JBTS37; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:32453716"
FT /id="VAR_085352"
FT CONFLICT 191
FT /note="E -> G (in Ref. 4; CAH18354)"
FT /evidence="ECO:0000305"
FT CONFLICT 477
FT /note="E -> K (in Ref. 1; BAA24853)"
FT /evidence="ECO:0000305"
FT CONFLICT 992
FT /note="S -> L (in Ref. 1; BAA24853)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1720 AA; 189360 MW; B07E731FDE69EE7D CRC64;
MAAAPSALLL LPPFPVLSTY RLQSRSRPSA PETDDSRVGG IMRGEKNYYF RGAAGDHGSC
PTTTSPLASA LLMPSEAVSS SWSESGGGLS GGDEEDTRLL QLLRTARDPS EAFQALQAAL
PRRGGRLGFP RRKEALYRAL GRVLVEGGSD EKRLCLQLLS DVLRGQGEAG QLEEAFSLAL
LPQLVVSLRE ENPALRKDAL QILHICLKRS PGEVLRTLIQ QGLESTDARL RASTALLLPI
LLTTEDLLLG LDLTEVIISL ARKLGDQETE EESETAFSAL QQIGERLGQD RFQSYISRLP
SALRRHYNRR LESQFGSQVP YYLELEASGF PEDPLPCAVT LSNSNLKFGI IPQELHSRLL
DQEDYKNRTQ AVEELKQVLG KFNPSSTPHS SLVGFISLLY NLLDDSNFKV VHGTLEVLHL
LVIRLGEQVQ QFLGPVIAAS VKVLADNKLV IKQEYMKIFL KLMKEVGPQQ VLCLLLEHLK
HKHSRVREEV VNICICSLLT YPSEDFDLPK LSFDLAPALV DSKRRVRQAA LEAFAVLASS
MGSGKTSILF KAVDTVELQD NGDGVMNAVQ ARLARKTLPR LTEQGFVEYA VLMPSSAGGR
SNHLAHGADT DWLLAGNRTQ SAHCHCGDHV RDSMHIYGSY SPTICTRRVL SAGKGKNKLP
WENEQPGIMG ENQTSTSKDI EQFSTYDFIP SAKLKLSQGM PVNDDLCFSR KRVSRNLFQN
SRDFNPDCLP LCAAGTTGTH QTNLSGKCAQ LGFSQICGKT GSVGSDLQFL GTTSSHQEKV
YASLNFGSKT QQTFGSQTEC TSSNGQNPSP GAYILPSYPV SSPRTSPKHT SPLIISPKKS
QDNSVNFSNS WPLKSFEGLS KPSPQKKLVS QKSSDPTGRN HGENSQEKPP VQLTPALVRS
PSSRRGLNGT KPVPPIPRGI SLLPDKADLS TVGHKKKEPD DIWKCEKDSL PIDLSELNFK
DKDLDQEEMH SSLRSLRNSA AKKRAKLSGS TSDLESPDSA MKLDLTMDSP SLSSSPNINS
YSESGVYSQE SLTSSLSTTP QGKRIMSDIF PTFGSKPCPT RLSSAKKKIS HIAEQSPSAG
SSSNPQQISS FDFTTTKALS EDSVVVVGKG VFGSLSSAPA TCSQSVISSV ENGDTFSIKQ
SIEPPSGIYG RSVQQNISSY LDVENEKDAK VSISKSTYNK MRQKRKEEKE LFHNKDCEKK
EKNSWERMRH TGTEKMASES ETPTGAISQY KERMPSVTHS PEIMDLSELR PFSKPEIALT
EALRLLADED WEKKIEGLNF IRCLAAFHSE ILNTKLHETN FAVVQEVKNL RSGVSRAAVV
CLSDLFTYLK KSMDQELDTT VKVLLHKAGE SNTFIREDVD KALRAMVNNV TPARAVVSLI
NGGQRYYGRK MLFFMMCHPN FEKMLEKYVP SKDLPYIKDS VRNLQQKGLG EIPLDTPSAK
GRRSHTGSVG NTRSSSVSRD AFNSAERAVT EVREVTRKSV PRNSLESAEY LKLITGLLNA
KDFRDRINGI KQLLSDTENN QDLVVGNIVK IFDAFKSRLH DSNSKVNLVA LETMHKMIPL
LRDHLSPIIN MLIPAIVDNN LNSKNPGIYA AATNVVQALS QHVDNYLLLQ PFCTKAQFLN
GKAKQDMTEK LADIVTELYQ RKPHATEQKV LVVLWHLLGN MTNSGSLPGA GGNIRTATAK
LSKALFAQMG QNLLNQAASQ PPHIKKSLEE LLDMTILNEL
