TGRM2_HUMAN
ID TGRM2_HUMAN Reviewed; 1019 AA.
AC Q6ZUX3; Q6ZUF5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=TOG array regulator of axonemal microtubules protein 2 {ECO:0000312|HGNC:HGNC:33715};
DE AltName: Full=Crescerin-2 {ECO:0000305};
GN Name=TOGARAM2 {ECO:0000312|HGNC:HGNC:33715}; Synonyms=FAM179A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANTS
RP CYS-724; ALA-941 AND VAL-944.
RC TISSUE=Heart, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6ZUX3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZUX3-2; Sequence=VSP_032492;
CC Name=3;
CC IsoId=Q6ZUX3-3; Sequence=VSP_032491, VSP_032493, VSP_032494,
CC VSP_032495;
CC -!- SIMILARITY: Belongs to the Crescerin family. {ECO:0000305}.
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DR EMBL; AK125239; BAC86095.1; -; mRNA.
DR EMBL; AK125744; BAC86270.1; -; mRNA.
DR EMBL; AC105398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS1769.2; -. [Q6ZUX3-1]
DR RefSeq; NP_954974.2; NM_199280.2. [Q6ZUX3-1]
DR RefSeq; XP_011530933.1; XM_011532631.1. [Q6ZUX3-2]
DR RefSeq; XP_016858996.1; XM_017003507.1. [Q6ZUX3-1]
DR RefSeq; XP_016859004.1; XM_017003515.1. [Q6ZUX3-2]
DR AlphaFoldDB; Q6ZUX3; -.
DR IntAct; Q6ZUX3; 1.
DR STRING; 9606.ENSP00000368876; -.
DR iPTMnet; Q6ZUX3; -.
DR PhosphoSitePlus; Q6ZUX3; -.
DR BioMuta; TOGARAM2; -.
DR DMDM; 172046176; -.
DR jPOST; Q6ZUX3; -.
DR MassIVE; Q6ZUX3; -.
DR PaxDb; Q6ZUX3; -.
DR PeptideAtlas; Q6ZUX3; -.
DR PRIDE; Q6ZUX3; -.
DR ProteomicsDB; 68373; -. [Q6ZUX3-1]
DR ProteomicsDB; 68374; -. [Q6ZUX3-2]
DR ProteomicsDB; 68375; -. [Q6ZUX3-3]
DR Antibodypedia; 51094; 11 antibodies from 6 providers.
DR DNASU; 165186; -.
DR Ensembl; ENST00000379558.5; ENSP00000368876.3; ENSG00000189350.13. [Q6ZUX3-1]
DR GeneID; 165186; -.
DR KEGG; hsa:165186; -.
DR MANE-Select; ENST00000379558.5; ENSP00000368876.3; NM_199280.4; NP_954974.2.
DR UCSC; uc010ezl.4; human. [Q6ZUX3-1]
DR CTD; 165186; -.
DR DisGeNET; 165186; -.
DR GeneCards; TOGARAM2; -.
DR HGNC; HGNC:33715; TOGARAM2.
DR HPA; ENSG00000189350; Group enriched (brain, choroid plexus, fallopian tube).
DR neXtProt; NX_Q6ZUX3; -.
DR OpenTargets; ENSG00000189350; -.
DR PharmGKB; PA162387471; -.
DR VEuPathDB; HostDB:ENSG00000189350; -.
DR eggNOG; KOG2933; Eukaryota.
DR GeneTree; ENSGT00940000156217; -.
DR HOGENOM; CLU_306027_0_0_1; -.
DR InParanoid; Q6ZUX3; -.
DR OMA; RAFMKEG; -.
DR OrthoDB; 476837at2759; -.
DR PhylomeDB; Q6ZUX3; -.
DR TreeFam; TF315518; -.
DR PathwayCommons; Q6ZUX3; -.
DR BioGRID-ORCS; 165186; 7 hits in 1055 CRISPR screens.
DR GenomeRNAi; 165186; -.
DR Pharos; Q6ZUX3; Tdark.
DR PRO; PR:Q6ZUX3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6ZUX3; protein.
DR Bgee; ENSG00000189350; Expressed in right uterine tube and 122 other tissues.
DR ExpressionAtlas; Q6ZUX3; baseline and differential.
DR Genevisible; Q6ZUX3; HS.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR GO; GO:0051128; P:regulation of cellular component organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR Pfam; PF12348; CLASP_N; 1.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..1019
FT /note="TOG array regulator of axonemal microtubules protein
FT 2"
FT /id="PRO_0000325938"
FT REGION 28..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..702
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032491"
FT VAR_SEQ 1..473
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032492"
FT VAR_SEQ 703..710
FT /note="VMAAIKQQ -> MLCVYFFK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032493"
FT VAR_SEQ 908..949
FT /note="VLVASVYPRKPQAVERHVLPILWHFLNTATRNGTLPGPSGNI -> GEHPQP
FT HPTPSPGRFLFSPGLWLNHSPSYLRPEIIPPNHLKF (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032494"
FT VAR_SEQ 950..1019
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032495"
FT VARIANT 55
FT /note="A -> T (in dbSNP:rs13009279)"
FT /id="VAR_054091"
FT VARIANT 265
FT /note="Q -> R (in dbSNP:rs12623297)"
FT /id="VAR_054092"
FT VARIANT 362
FT /note="Q -> R (in dbSNP:rs11127202)"
FT /id="VAR_054093"
FT VARIANT 441
FT /note="I -> V (in dbSNP:rs1109758)"
FT /id="VAR_054094"
FT VARIANT 535
FT /note="V -> A (in dbSNP:rs6721861)"
FT /id="VAR_054095"
FT VARIANT 724
FT /note="R -> C (in dbSNP:rs60403047)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_062242"
FT VARIANT 941
FT /note="T -> A (in dbSNP:rs895591)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_054096"
FT VARIANT 944
FT /note="G -> V (in dbSNP:rs7577483)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_054097"
FT CONFLICT 750
FT /note="L -> P (in Ref. 1; BAC86270)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1019 AA; 111153 MW; 51A2A3CD3FAAE9CE CRC64;
MGTRDDVPEA KVLVPVAVYC GSIPRTSAGP RVLPPGSINS SLPHGEGSLQ PEPRALLNNE
EPSQLLRGLG QLGGLKLDTP SKGWQARNGH PRNLRALSLG DQPLVLLPSP ESEANSVARD
TIQIKDKLKK RRLSEGLAAS SRASLDPGGG PQGVPLHSTI PRATSQRLLR VPRPMPLIQS
IPTTPEASGV KEKGLDLPGS IPGPHELRPG AQEAQISWQY LHCNDEKMQK SLGAIVIPPI
PKARTVAATP SRVPGSLPSP LPPGQGVLTG LRAPRTRLAR GSGPREKTPA SLEPKPLASP
IRDRPAAAKK PALPFSQSAP TLTAFSFDCA REACPPLKEE DQKEIGTKIQ VTISKSAREK
MQLKQMKEME LLRRLEEPRT GQELTSQCLG SQRAFMKEGL LPLRGSGTLS VPTRLSGPCR
NDVSIILRKW ASRASLPSIP ISRQEPRFAR HASANSLPAV LTLGSPEWEE EEEMDLRACK
ELRPFSNPEL GLRDALQCLN SSDWQMKEKG LVSIQRLAAC HSEVLTGKLH DVCLVVTGEV
TNLRSKVSHL AISTLGDLFQ ALKKNMDQEA EEIARCLLQK MADTNEFIQR AAGQSLRAMV
ENVTLARSLV VLTSAGVYHR NPLIRKYAAE HLSAVLEQIG AEKLLSGTRD STDMLVHNLV
RLAQDSNQDT RFYGRKMVNI LMANTKFDAF LKQSLPSYDL QKVMAAIKQQ GIEDNDELPS
AKGRKVLRSL VVCENGLPIK EGLSCNGPRL VGLRSTLQGR GEMVEQLREL TRLLEAKDFR
SRMEGVGQLL ELCKAKTELV TAHLVQVFDA FTPRLQDSNK KVNQWALESF AKMIPLLRES
LHPMLLSIII TVADNLNSKN SGIYAAAVAV LDAMVESLDN LCLLPALAGR VRFLSGRAVL
DVTDRLAVLV ASVYPRKPQA VERHVLPILW HFLNTATRNG TLPGPSGNIR GVVCRLSRSL
QEHMGSRLLD FAASQPKHVL KTLQELLDSE SLGGSRKATD RGVAPDSKTT GSSYPFQLD
