TGRM2_MOUSE
ID TGRM2_MOUSE Reviewed; 1002 AA.
AC Q3TYG6; Q8C7B2;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=TOG array regulator of axonemal microtubules protein 2;
DE AltName: Full=Crescerin-2 {ECO:0000303|PubMed:26378256};
DE AltName: Full=Protein FAM179A;
GN Name=Togaram2; Synonyms=Fam179a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Heart, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=26378256; DOI=10.1091/mbc.e15-08-0603;
RA Das A., Dickinson D.J., Wood C.C., Goldstein B., Slep K.C.;
RT "Crescerin uses a TOG domain array to regulate microtubules in the primary
RT cilium.";
RL Mol. Biol. Cell 26:4248-4264(2015).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3TYG6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TYG6-2; Sequence=VSP_032496, VSP_032497;
CC -!- SIMILARITY: Belongs to the Crescerin family. {ECO:0000305}.
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DR EMBL; AK052197; BAC34879.1; -; mRNA.
DR EMBL; AK158647; BAE34597.1; -; mRNA.
DR CCDS; CCDS28961.2; -. [Q3TYG6-1]
DR RefSeq; NP_796061.2; NM_177087.4. [Q3TYG6-1]
DR AlphaFoldDB; Q3TYG6; -.
DR BioGRID; 235805; 1.
DR STRING; 10090.ENSMUSP00000114359; -.
DR iPTMnet; Q3TYG6; -.
DR PhosphoSitePlus; Q3TYG6; -.
DR PaxDb; Q3TYG6; -.
DR PRIDE; Q3TYG6; -.
DR ProteomicsDB; 258869; -. [Q3TYG6-1]
DR ProteomicsDB; 258870; -. [Q3TYG6-2]
DR Antibodypedia; 51094; 11 antibodies from 6 providers.
DR DNASU; 320159; -.
DR Ensembl; ENSMUST00000097284; ENSMUSP00000094886; ENSMUSG00000045761. [Q3TYG6-1]
DR Ensembl; ENSMUST00000153445; ENSMUSP00000122691; ENSMUSG00000045761. [Q3TYG6-1]
DR GeneID; 320159; -.
DR KEGG; mmu:320159; -.
DR UCSC; uc008dmt.1; mouse. [Q3TYG6-1]
DR CTD; 165186; -.
DR MGI; MGI:2443498; Togaram2.
DR VEuPathDB; HostDB:ENSMUSG00000045761; -.
DR eggNOG; KOG2933; Eukaryota.
DR GeneTree; ENSGT00940000156217; -.
DR HOGENOM; CLU_306027_0_0_1; -.
DR InParanoid; Q3TYG6; -.
DR OMA; RAFMKEG; -.
DR OrthoDB; 476837at2759; -.
DR PhylomeDB; Q3TYG6; -.
DR BioGRID-ORCS; 320159; 2 hits in 70 CRISPR screens.
DR PRO; PR:Q3TYG6; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q3TYG6; protein.
DR Bgee; ENSMUSG00000045761; Expressed in olfactory epithelium and 44 other tissues.
DR ExpressionAtlas; Q3TYG6; baseline and differential.
DR Genevisible; Q3TYG6; MM.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR GO; GO:0051128; P:regulation of cellular component organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR Pfam; PF12348; CLASP_N; 1.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..1002
FT /note="TOG array regulator of axonemal microtubules protein
FT 2"
FT /id="PRO_0000325939"
FT REGION 54..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..706
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032496"
FT VAR_SEQ 707..743
FT /note="AIKQRGIQDNHELQSAKGRKVSKSLVVCENGLPSHEG -> MCSSPGLFPRG
FT QPLLPPRLGSNGPRLMGLRSSSVRGS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032497"
SQ SEQUENCE 1002 AA; 108975 MW; 0E0FC802EC2A4858 CRC64;
MDTRDDVTLA KVPAPVAVYC GSVPRTSVGL RAPPPGGIDS SLLAHDEASL QPVSSVLPSS
EKPSQLSREH EDQSSLMLNA PLKGWQARNG YPRGLGVLPL GHHLGAAIPS LESEASSVAR
DTIQIKDKLK KRRLSEGMAA SSQASLDPVG GPRGVPLRST IPRTTSQRLL RVPRPMPPIQ
SIPTTPEANS AKEKDLDPPG GRQDLQDPGA SAQEVQISRQ YLHCADEKMH KSLGGLVIPP
IPKARMPTGT SSCRPGSLPS PLCPSQDVLM GPKAPHTRLT CENGPLEKTP KSPASKPLVP
VVKAKSAEAP ETSLASSQST FTLTAFSSHA KETRSLENEE DQKESSTKVQ VTISKSAQEK
MRLKQMKEME LLRRAKEPEW ERELVSQGLG TRRTSAKEGL LPLRGSGALS EPAGMSSPRR
NNMGALQRKR ANRASLPSIP VSKQEPGFAR HASANSLPAV LTLGSPEWEE EEEEMDLRAL
RELRPFSNPE LGLTDALQCL NSNDWQMKEK GLVNIQRLAA CHSEVLGTRL HDVSLAVTAE
VTNLRSKVSR LAISTLGDLF RVLKKNMDQE AEEIVRCLLQ KMGNTSEFIQ RAANRALGAM
VENVTPARAL VALTSAGVYH RNPLVRKCTA KHLSAVLEQI GAEKLLSGSR DNTDMLVHNL
VRLAQDSNQD TRFYGRKMVN ILMANAKFDA FLKQSLPSHD LRKVMAAIKQ RGIQDNHELQ
SAKGRKVSKS LVVCENGLPS HEGVETSEQL RELTRLLEAK EFQARMEGVG KLLEYCKAKP
ELVAANLVQV FDVFTPRLHD SNKKVNQWAL ESLAQMLPIL KESIHPMLLS LIIAAADNLN
SKNSGISTAA STVLDAMMGS LDHLCLLQAF AGRVRFLTGP AVLDITDRLS VLVASVYPRK
PQAVERHILP VLWYFLNKMS GNGVLPGRGG NVRTAVCRLA RSLQEQMGSR LQDFAASQPQ
QVLKALQGLL ASESLGANDK VIGGRMAPDI QMTGTTCPQQ LD
