ID   BREF8_EUPBR             Reviewed;         248 AA.
AC   A0A068A9T3;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2014, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Probable C2H2-type zinc-finger transcription factor orf8 {ECO:0000250|UniProtKB:Q5B7I8};
DE   AltName: Full=Brefeldin A biosynthesis cluster protein orf8 {ECO:0000303|PubMed:24845309};
GN   Name=orf8 {ECO:0000303|PubMed:24845309};
OS   Eupenicillium brefeldianum (Penicillium brefeldianum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=1131482;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RC   STRAIN=ATCC 58665;
RX   PubMed=24845309; DOI=10.1021/cb500284t;
RA   Zabala A.O., Chooi Y.H., Choi M.S., Lin H.C., Tang Y.;
RT   "Fungal polyketide synthase product chain-length control by partnering
RT   thiohydrolase.";
RL   ACS Chem. Biol. 9:1576-1586(2014).
CC   -!- FUNCTION: Probable C2H2-type zinc-finger transcription factor that may
CC       regulate the gene cluster that mediates the biosynthesis of brefeldin A
CC       (BFA), a protein transport inhibitor that shows antiviral, antifungal,
CC       and antitumor properties. {ECO:0000305|PubMed:24845309}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: Coexpressed with the other cluster genes on brefeldin A
CC       production optimized medium. {ECO:0000269|PubMed:24845309}.
CC   -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; KJ728786; AIA58900.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A068A9T3; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..248
FT                   /note="Probable C2H2-type zinc-finger transcription factor
FT                   orf8"
FT                   /id="PRO_0000444936"
FT   ZN_FING         218..241
FT                   /note="C2H2-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          62..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   248 AA;  27256 MW;  FF11246288C680A5 CRC64;
     MSGSSEPYSD EPSQHNTHRF IDQIPDYPWD DYSGPPLQQS RGYSSQDLSP LQTYYSSGLS
     VGLNGQTGGS ESGGSQSGGS DYSYSQNVPA SLLPPAFYLV RSDSYPGTGI ESRLPNSYLL
     SYPPSPTDPN TYYMPETSQF LPSHDLSLSV QDSSEILDSL FPQQESPSVT SNDEFLVQIL
     SSRPRPQCWD HGCNGREFSS MSNLLRHQRE RAGAVTKAEC PVCGAVFTRT TARNIHVFER
     CEGIGRSL