BRI3B_MOUSE
ID BRI3B_MOUSE Reviewed; 253 AA.
AC Q8BXV2; Q8BXP1; Q9CWE5;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=BRI3-binding protein;
DE Short=I3-binding protein;
GN Name=Bri3bp {ECO:0000312|MGI:MGI:1924059};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAC31516.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC31516.1};
RC TISSUE=Cerebellum {ECO:0000312|EMBL:BAC31516.1},
RC Embryo {ECO:0000312|EMBL:BAE25425.1},
RC Embryonic stem cell {ECO:0000312|EMBL:BAB27196.1}, and
RC Retina {ECO:0000312|EMBL:BAC31982.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000312|EMBL:AAH39941.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II {ECO:0000312|EMBL:AAH39941.1};
RC TISSUE=Mammary gland {ECO:0000312|EMBL:AAH39941.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND PROTO-ONCOGENICITY.
RX PubMed=17943721; DOI=10.1002/ijc.23146;
RA Ha S.A., Shin S.M., Lee Y.J., Kim S., Kim H.K., Namkoong H., Lee H.,
RA Lee Y.S., Cho Y.S., Park Y.G., Jeon H.M., Oh C., Kim J.W.;
RT "HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through
RT P53 stabilization.";
RL Int. J. Cancer 122:501-508(2008).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in tumorigenesis and may function by stabilizing
CC p53/TP53. {ECO:0000269|PubMed:17943721}.
CC -!- SUBUNIT: Interacts with LETMD1. Interacts with BRI3.
CC {ECO:0000250|UniProtKB:Q8WY22}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
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DR EMBL; AK010810; BAB27196.1; -; mRNA.
DR EMBL; AK043288; BAC31516.1; -; mRNA.
DR EMBL; AK044565; BAC31982.1; -; mRNA.
DR EMBL; AK143538; BAE25425.1; -; mRNA.
DR EMBL; BC039941; AAH39941.1; -; mRNA.
DR CCDS; CCDS19686.1; -.
DR RefSeq; NP_084028.1; NM_029752.2.
DR AlphaFoldDB; Q8BXV2; -.
DR BioGRID; 218329; 4.
DR IntAct; Q8BXV2; 1.
DR STRING; 10090.ENSMUSP00000037609; -.
DR TCDB; 1.A.74.2.1; the mitsugumin 23 (mg23) family.
DR iPTMnet; Q8BXV2; -.
DR PhosphoSitePlus; Q8BXV2; -.
DR SwissPalm; Q8BXV2; -.
DR EPD; Q8BXV2; -.
DR MaxQB; Q8BXV2; -.
DR PaxDb; Q8BXV2; -.
DR PeptideAtlas; Q8BXV2; -.
DR PRIDE; Q8BXV2; -.
DR ProteomicsDB; 273842; -.
DR Antibodypedia; 2692; 169 antibodies from 28 providers.
DR Ensembl; ENSMUST00000049040; ENSMUSP00000037609; ENSMUSG00000037905.
DR GeneID; 76809; -.
DR KEGG; mmu:76809; -.
DR UCSC; uc008zrr.1; mouse.
DR CTD; 140707; -.
DR MGI; MGI:1924059; Bri3bp.
DR VEuPathDB; HostDB:ENSMUSG00000037905; -.
DR eggNOG; ENOG502QRNV; Eukaryota.
DR GeneTree; ENSGT00390000002024; -.
DR HOGENOM; CLU_095006_0_0_1; -.
DR InParanoid; Q8BXV2; -.
DR OMA; LMDTFWR; -.
DR OrthoDB; 1317796at2759; -.
DR PhylomeDB; Q8BXV2; -.
DR TreeFam; TF332238; -.
DR BioGRID-ORCS; 76809; 2 hits in 41 CRISPR screens.
DR ChiTaRS; Bri3bp; mouse.
DR PRO; PR:Q8BXV2; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8BXV2; protein.
DR Bgee; ENSMUSG00000037905; Expressed in manus and 220 other tissues.
DR ExpressionAtlas; Q8BXV2; baseline and differential.
DR Genevisible; Q8BXV2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR InterPro; IPR033367; BRI3BP.
DR PANTHER; PTHR31253; PTHR31253; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Phosphoprotein; Proto-oncogene; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..253
FT /note="BRI3-binding protein"
FT /id="PRO_0000229748"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 219..253
FT /evidence="ECO:0000255"
FT MOD_RES 250
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WY22"
FT CONFLICT 7
FT /note="Q -> E (in Ref. 1; BAC31982)"
FT /evidence="ECO:0000305"
FT CONFLICT 217
FT /note="L -> F (in Ref. 1; BAB27196)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 253 AA; 28263 MW; 9FEBE500086CAC68 CRC64;
MGARASQEPR TRVRAGLRVL LPVLLLALLL LALVAPGAQG ARGRGAADKN SHRRATSSFS
QSVSSLFGED NVRAAQKLLS RLTERFVQGV DMFLETLWKV WMELLEVLGL DVSNLSQYFS
PASVSNSPTR ALVLVGVVLL AYWFLSLTLG FTFSLLHLVF GRFFWLVRVI LFSMSCVYIL
HKYEGEPEHA VLPLCVVVAI YFMTGPMGYW RGSPGGLCSP SVEEKLEHLE NQVRLLNIRL
NRVLENLDRS KDK
