ID   BRI3_BOVIN              Reviewed;         124 AA.
AC   Q32L83;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Brain protein I3;
GN   Name=BRI3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in tumor necrosis factor-alpha (TNF)-induced
CC       cell death. May be a target of Wnt/beta-catenin signaling in the liver.
CC       {ECO:0000250|UniProtKB:O95415}.
CC   -!- SUBUNIT: Interacts with BRI3BP. Interacts with MGAT1 and IFITM3 (By
CC       similarity). {ECO:0000250|UniProtKB:O95415}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:O95415};
CC       Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear
CC       region {ECO:0000250|UniProtKB:O95415}. Note=Co-localizes with MGAT1 and
CC       IFITM3 at the perinuclear region. {ECO:0000250|UniProtKB:O95415}.
CC   -!- SIMILARITY: Belongs to the BRI3 family. {ECO:0000305}.
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DR   EMBL; BC109710; AAI09711.1; -; mRNA.
DR   RefSeq; NP_001035673.1; NM_001040583.1.
DR   AlphaFoldDB; Q32L83; -.
DR   STRING; 9913.ENSBTAP00000048073; -.
DR   PaxDb; Q32L83; -.
DR   PRIDE; Q32L83; -.
DR   Ensembl; ENSBTAT00000055646; ENSBTAP00000048073; ENSBTAG00000022825.
DR   GeneID; 615390; -.
DR   KEGG; bta:615390; -.
DR   CTD; 25798; -.
DR   VEuPathDB; HostDB:ENSBTAG00000022825; -.
DR   VGNC; VGNC:26564; BRI3.
DR   eggNOG; KOG4517; Eukaryota.
DR   GeneTree; ENSGT00510000048486; -.
DR   InParanoid; Q32L83; -.
DR   OMA; YEYGPQQ; -.
DR   OrthoDB; 1433992at2759; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000022825; Expressed in tongue muscle and 104 other tissues.
DR   ExpressionAtlas; Q32L83; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019317; Brain_I3.
DR   PANTHER; PTHR13551; PTHR13551; 1.
DR   Pfam; PF10164; DUF2367; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..124
FT                   /note="Brain protein I3"
FT                   /id="PRO_0000317692"
FT   TRANSMEM        66..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   124 AA;  13560 MW;  6B6F5E1D844C244B CRC64;
     MDHKPLLQER PPAYNLEAGQ GEFACAPHGY GAIAAAPPPP YPYLVTGIPT HHPRVYNIHS
     RNVTRYPANS IVVVGGCPVC RVGVLEDSFT FLGIFLAIVL FPFGFICCFA LRKRRCPNCG
     ANFT