ID   BRI3_CAVPO              Reviewed;         125 AA.
AC   Q99N46;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Brain protein I3;
GN   Name=I3;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hartley; TISSUE=Spleen;
RA   Nakada-Tsukui K., Ohtani M., Kobayashi Y., Watanabe N.;
RT   "Identification and characterization of I3 gene associated with the guinea
RT   pig skin delayed-type hypersensitivity reaction.";
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in tumor necrosis factor-alpha (TNF)-induced
CC       cell death. May be a target of Wnt/beta-catenin signaling in the liver.
CC       {ECO:0000250|UniProtKB:O95415}.
CC   -!- SUBUNIT: Interacts with BRI3BP. Interacts with MGAT1 and IFITM3 (By
CC       similarity). {ECO:0000250|UniProtKB:O95415}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:O95415};
CC       Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear
CC       region {ECO:0000250|UniProtKB:O95415}. Note=Co-localizes with MGAT1 and
CC       IFITM3 at the perinuclear region. {ECO:0000250|UniProtKB:O95415}.
CC   -!- SIMILARITY: Belongs to the BRI3 family. {ECO:0000305}.
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DR   EMBL; AB058506; BAB39857.1; -; mRNA.
DR   RefSeq; NP_001166298.1; NM_001172827.1.
DR   AlphaFoldDB; Q99N46; -.
DR   STRING; 10141.ENSCPOP00000020651; -.
DR   Ensembl; ENSCPOT00000020398; ENSCPOP00000020651; ENSCPOG00000025281.
DR   GeneID; 100379532; -.
DR   KEGG; cpoc:100379532; -.
DR   CTD; 25798; -.
DR   eggNOG; KOG4517; Eukaryota.
DR   GeneTree; ENSGT00510000048486; -.
DR   HOGENOM; CLU_138141_0_0_1; -.
DR   InParanoid; Q99N46; -.
DR   OMA; YEYGPQQ; -.
DR   OrthoDB; 1433992at2759; -.
DR   TreeFam; TF329242; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000025281; Expressed in heart and 13 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   InterPro; IPR019317; Brain_I3.
DR   PANTHER; PTHR13551; PTHR13551; 1.
DR   Pfam; PF10164; DUF2367; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..125
FT                   /note="Brain protein I3"
FT                   /id="PRO_0000317693"
FT   TRANSMEM        67..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   125 AA;  13558 MW;  D9E33D1DA042B88B CRC64;
     MDHKPLLQER PPAYNLEAGQ GDYACGAPGY GAIPSAPPPP PYPYLVTGIP TPHPRVYSIH
     SRTVTRYPAN SIVVVGGCPV CRVGVLEDCF TFLGIFLAII LFPFGFICCF ALRKRRCPNC
     GATFT