ID   BRI3_MOUSE              Reviewed;         125 AA.
AC   P28662; Q501N3; Q9Z1S1;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Brain protein I3;
GN   Name=Bri3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Adler H.J., Warner S.J., Rossi A.M., Lomax M.I.;
RT   "The gene encoding the chick orthologue of mouse brain protein I3 is
RT   expressed in the inner ear.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=NMRI; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 67-125.
RC   STRAIN=BALB/cJ; TISSUE=Brain;
RX   PubMed=12106288; DOI=10.1111/j.1460-9568.1990.tb00460.x;
RA   Kato K.;
RT   "A collection of cDNA clones with specific expression patterns in mouse
RT   brain.";
RL   Eur. J. Neurosci. 2:704-711(1990).
RN   [4]
RP   FUNCTION, AND INDUCTION.
RX   DOI=10.1360/02tb9088;
RA   Lin L., Yu H., Ying M., Tang J., Zhou W., Zhao S., Li C.;
RT   "Cloning of murine BRI3 gene and study on its function for inducing cell
RT   death.";
RL   Chin. Sci. Bull. 47:376-379(2002).
CC   -!- FUNCTION: Participates in tumor necrosis factor-alpha (TNF)-induced
CC       cell death (Ref.4). May be a target of Wnt/beta-catenin signaling in
CC       the liver (By similarity). {ECO:0000250|UniProtKB:O95415,
CC       ECO:0000269|Ref.4}.
CC   -!- SUBUNIT: Interacts with BRI3BP. Interacts with MGAT1 and IFITM3 (By
CC       similarity). {ECO:0000250|UniProtKB:O95415}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:O95415};
CC       Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear
CC       region {ECO:0000250|UniProtKB:O95415}. Note=Co-localizes with MGAT1 and
CC       IFITM3 at the perinuclear region. {ECO:0000250|UniProtKB:O95415}.
CC   -!- TISSUE SPECIFICITY: High expression in cerebral cortex, and in
CC       cerebellar cortex.
CC   -!- INDUCTION: Up-regulated during TNF-mediated inflammation and immunity.
CC       {ECO:0000269|Ref.4}.
CC   -!- SIMILARITY: Belongs to the BRI3 family. {ECO:0000305}.
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DR   EMBL; AF106967; AAD05168.1; -; mRNA.
DR   EMBL; BC095955; AAH95955.1; -; mRNA.
DR   EMBL; X61454; CAA43694.1; -; mRNA.
DR   CCDS; CCDS19848.1; -.
DR   PIR; S16868; S16868.
DR   RefSeq; NP_061242.3; NM_018772.4.
DR   AlphaFoldDB; P28662; -.
DR   STRING; 10090.ENSMUSP00000057263; -.
DR   PhosphoSitePlus; P28662; -.
DR   PaxDb; P28662; -.
DR   PRIDE; P28662; -.
DR   ProteomicsDB; 273765; -.
DR   Antibodypedia; 49158; 51 antibodies from 19 providers.
DR   DNASU; 55950; -.
DR   Ensembl; ENSMUST00000056578; ENSMUSP00000057263; ENSMUSG00000047843.
DR   GeneID; 55950; -.
DR   KEGG; mmu:55950; -.
DR   UCSC; uc009alo.2; mouse.
DR   CTD; 25798; -.
DR   MGI; MGI:1933174; Bri3.
DR   VEuPathDB; HostDB:ENSMUSG00000047843; -.
DR   eggNOG; KOG4517; Eukaryota.
DR   GeneTree; ENSGT00510000048486; -.
DR   HOGENOM; CLU_138141_0_0_1; -.
DR   InParanoid; P28662; -.
DR   OMA; YEYGPQQ; -.
DR   OrthoDB; 1433992at2759; -.
DR   PhylomeDB; P28662; -.
DR   TreeFam; TF329242; -.
DR   Reactome; R-MMU-6798695; Neutrophil degranulation.
DR   BioGRID-ORCS; 55950; 5 hits in 73 CRISPR screens.
DR   ChiTaRS; Bri3; mouse.
DR   PRO; PR:P28662; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; P28662; protein.
DR   Bgee; ENSMUSG00000047843; Expressed in animal zygote and 67 other tissues.
DR   ExpressionAtlas; P28662; baseline and differential.
DR   Genevisible; P28662; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   InterPro; IPR019317; Brain_I3.
DR   PANTHER; PTHR13551; PTHR13551; 1.
DR   Pfam; PF10164; DUF2367; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..125
FT                   /note="Brain protein I3"
FT                   /id="PRO_0000064924"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        119..125
FT                   /note="NCGAVFT -> TVERSLLRGNSTPSFP (in Ref. 3; CAA43694)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   125 AA;  13643 MW;  45BBE06BC77AD936 CRC64;
     MDHKPLLQER PPAYNLEAGQ GDYACGPHGY GAIPTAPPPP PYPYLVTGIP TSHPRVYNIH
     SRTVTRYPAN SIVVVGGCPV CRVGVLEYCF TCLGIFLAIV LFPFGFLCCF ALRKRRCPNC
     GAVFT