ID   BRI3_RAT                Reviewed;         125 AA.
AC   Q5PPK1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Brain protein I3;
GN   Name=Bri3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Participates in tumor necrosis factor-alpha (TNF)-induced
CC       cell death. May be a target of Wnt/beta-catenin signaling in the liver.
CC       {ECO:0000250|UniProtKB:O95415}.
CC   -!- SUBUNIT: Interacts with BRI3BP. Interacts with MGAT1 and IFITM3 (By
CC       similarity). {ECO:0000250|UniProtKB:O95415}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:O95415};
CC       Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear
CC       region {ECO:0000250|UniProtKB:O95415}. Note=Co-localizes with MGAT1 and
CC       IFITM3 at the perinuclear region. {ECO:0000250|UniProtKB:O95415}.
CC   -!- SIMILARITY: Belongs to the BRI3 family. {ECO:0000305}.
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DR   EMBL; BC087646; AAH87646.1; -; mRNA.
DR   RefSeq; NP_001009604.1; NM_001009604.1.
DR   AlphaFoldDB; Q5PPK1; -.
DR   STRING; 10116.ENSRNOP00000001336; -.
DR   PaxDb; Q5PPK1; -.
DR   Ensembl; ENSRNOT00000001336; ENSRNOP00000001336; ENSRNOG00000001009.
DR   GeneID; 304284; -.
DR   KEGG; rno:304284; -.
DR   CTD; 25798; -.
DR   RGD; 1309187; Bri3.
DR   eggNOG; KOG4517; Eukaryota.
DR   GeneTree; ENSGT00510000048486; -.
DR   HOGENOM; CLU_138141_0_0_1; -.
DR   InParanoid; Q5PPK1; -.
DR   OMA; YEYGPQQ; -.
DR   OrthoDB; 1433992at2759; -.
DR   PhylomeDB; Q5PPK1; -.
DR   TreeFam; TF329242; -.
DR   Reactome; R-RNO-6798695; Neutrophil degranulation.
DR   PRO; PR:Q5PPK1; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000001009; Expressed in kidney and 20 other tissues.
DR   Genevisible; Q5PPK1; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   InterPro; IPR019317; Brain_I3.
DR   PANTHER; PTHR13551; PTHR13551; 1.
DR   Pfam; PF10164; DUF2367; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..125
FT                   /note="Brain protein I3"
FT                   /id="PRO_0000317694"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   125 AA;  13613 MW;  45A78C1BC77ACC23 CRC64;
     MDHKPLLQER PPAYNLEAGQ GDYACGPHGY GAIPTAPPPP PYPYLVTGIP TSHPRVYNIH
     SRAVTRYPAN SIVVVGGCPV CRVGVLEYCF TCLGIFLAIV LFPFGFLCCF ALRKRRCPNC
     GAVFT