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BRID5_HUMAN
ID   BRID5_HUMAN             Reviewed;         260 AA.
AC   Q6PL45; C9J7K2; Q8IXU9;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 3.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=BRICHOS domain-containing protein 5;
GN   Name=BRICD5; Synonyms=C16orf79;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS GLY-31 AND
RP   ILE-46.
RA   Lin L., Zhong G., Ke R., Shen C., Li H., Zhou G., Yang S.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS GLY-31 AND
RP   ILE-46.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q6PL45; Q8N205: SYNE4; NbExp=3; IntAct=EBI-10254180, EBI-7131783;
CC       Q6PL45-2; Q13520: AQP6; NbExp=3; IntAct=EBI-12244618, EBI-13059134;
CC       Q6PL45-2; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-12244618, EBI-11343438;
CC       Q6PL45-2; Q13323: BIK; NbExp=3; IntAct=EBI-12244618, EBI-700794;
CC       Q6PL45-2; Q07108: CD69; NbExp=3; IntAct=EBI-12244618, EBI-2836595;
CC       Q6PL45-2; P11912: CD79A; NbExp=3; IntAct=EBI-12244618, EBI-7797864;
CC       Q6PL45-2; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-12244618, EBI-11749983;
CC       Q6PL45-2; P58418: CLRN1; NbExp=3; IntAct=EBI-12244618, EBI-17274839;
CC       Q6PL45-2; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-12244618, EBI-6942903;
CC       Q6PL45-2; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-12244618, EBI-3918971;
CC       Q6PL45-2; Q9UM44: HHLA2; NbExp=3; IntAct=EBI-12244618, EBI-2867874;
CC       Q6PL45-2; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-12244618, EBI-18053395;
CC       Q6PL45-2; P32942: ICAM3; NbExp=3; IntAct=EBI-12244618, EBI-725421;
CC       Q6PL45-2; P38484: IFNGR2; NbExp=3; IntAct=EBI-12244618, EBI-3905457;
CC       Q6PL45-2; Q8IU57: IFNLR1; NbExp=3; IntAct=EBI-12244618, EBI-373215;
CC       Q6PL45-2; Q6UWB1: IL27RA; NbExp=3; IntAct=EBI-12244618, EBI-19045531;
CC       Q6PL45-2; P43628: KIR2DL3; NbExp=3; IntAct=EBI-12244618, EBI-8632435;
CC       Q6PL45-2; P26715: KLRC1; NbExp=3; IntAct=EBI-12244618, EBI-9018187;
CC       Q6PL45-2; Q8N386: LRRC25; NbExp=3; IntAct=EBI-12244618, EBI-11304917;
CC       Q6PL45-2; Q9HCJ2: LRRC4C; NbExp=3; IntAct=EBI-12244618, EBI-3925442;
CC       Q6PL45-2; Q6IN84: MRM1; NbExp=3; IntAct=EBI-12244618, EBI-5454865;
CC       Q6PL45-2; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-12244618, EBI-3923617;
CC       Q6PL45-2; P15941-11: MUC1; NbExp=3; IntAct=EBI-12244618, EBI-17263240;
CC       Q6PL45-2; O14524-2: NEMP1; NbExp=3; IntAct=EBI-12244618, EBI-10969203;
CC       Q6PL45-2; Q53GL0: PLEKHO1; NbExp=3; IntAct=EBI-12244618, EBI-949945;
CC       Q6PL45-2; P15151: PVR; NbExp=3; IntAct=EBI-12244618, EBI-3919694;
CC       Q6PL45-2; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-12244618, EBI-17247926;
CC       Q6PL45-2; Q16585: SGCB; NbExp=3; IntAct=EBI-12244618, EBI-5663627;
CC       Q6PL45-2; O95470: SGPL1; NbExp=3; IntAct=EBI-12244618, EBI-1046170;
CC       Q6PL45-2; Q9Y336: SIGLEC9; NbExp=3; IntAct=EBI-12244618, EBI-12857926;
CC       Q6PL45-2; Q96DU3: SLAMF6; NbExp=3; IntAct=EBI-12244618, EBI-14058448;
CC       Q6PL45-2; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-12244618, EBI-17595455;
CC       Q6PL45-2; Q05940: SLC18A2; NbExp=3; IntAct=EBI-12244618, EBI-18036244;
CC       Q6PL45-2; Q99523: SORT1; NbExp=3; IntAct=EBI-12244618, EBI-1057058;
CC       Q6PL45-2; Q8WY98: TMEM234; NbExp=3; IntAct=EBI-12244618, EBI-8642211;
CC       Q6PL45-2; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-12244618, EBI-10314986;
CC       Q6PL45-2; Q9BSE2: TMEM79; NbExp=3; IntAct=EBI-12244618, EBI-8649725;
CC       Q6PL45-2; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-12244618, EBI-12345267;
CC       Q6PL45-2; Q9Y320: TMX2; NbExp=3; IntAct=EBI-12244618, EBI-6447886;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6PL45-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6PL45-2; Sequence=VSP_024411;
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DR   EMBL; AY597811; AAT09004.1; -; mRNA.
DR   EMBL; AC009065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC039154; AAH39154.1; -; mRNA.
DR   CCDS; CCDS10463.1; -. [Q6PL45-2]
DR   RefSeq; NP_872369.2; NM_182563.3. [Q6PL45-2]
DR   RefSeq; XP_005255320.1; XM_005255263.4.
DR   AlphaFoldDB; Q6PL45; -.
DR   BioGRID; 129693; 212.
DR   IntAct; Q6PL45; 39.
DR   GlyGen; Q6PL45; 1 site.
DR   iPTMnet; Q6PL45; -.
DR   PhosphoSitePlus; Q6PL45; -.
DR   BioMuta; BRICD5; -.
DR   DMDM; 308153611; -.
DR   MassIVE; Q6PL45; -.
DR   PeptideAtlas; Q6PL45; -.
DR   PRIDE; Q6PL45; -.
DR   ProteomicsDB; 67252; -. [Q6PL45-1]
DR   ProteomicsDB; 67253; -. [Q6PL45-2]
DR   Antibodypedia; 10344; 26 antibodies from 11 providers.
DR   DNASU; 283870; -.
DR   Ensembl; ENST00000328540.8; ENSP00000332389.3; ENSG00000182685.8. [Q6PL45-2]
DR   Ensembl; ENST00000562360.5; ENSP00000455052.1; ENSG00000182685.8. [Q6PL45-1]
DR   GeneID; 283870; -.
DR   KEGG; hsa:283870; -.
DR   MANE-Select; ENST00000328540.8; ENSP00000332389.3; NM_182563.4; NP_872369.2. [Q6PL45-2]
DR   UCSC; uc002cpi.3; human. [Q6PL45-1]
DR   CTD; 283870; -.
DR   DisGeNET; 283870; -.
DR   GeneCards; BRICD5; -.
DR   HGNC; HGNC:28309; BRICD5.
DR   HPA; ENSG00000182685; Low tissue specificity.
DR   neXtProt; NX_Q6PL45; -.
DR   OpenTargets; ENSG00000182685; -.
DR   PharmGKB; PA162378367; -.
DR   VEuPathDB; HostDB:ENSG00000182685; -.
DR   GeneTree; ENSGT00930000150969; -.
DR   HOGENOM; CLU_091731_0_0_1; -.
DR   InParanoid; Q6PL45; -.
DR   OMA; PQSNRSW; -.
DR   OrthoDB; 1064959at2759; -.
DR   PhylomeDB; Q6PL45; -.
DR   TreeFam; TF333439; -.
DR   PathwayCommons; Q6PL45; -.
DR   SignaLink; Q6PL45; -.
DR   BioGRID-ORCS; 283870; 15 hits in 1081 CRISPR screens.
DR   ChiTaRS; BRICD5; human.
DR   GenomeRNAi; 283870; -.
DR   Pharos; Q6PL45; Tdark.
DR   PRO; PR:Q6PL45; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q6PL45; protein.
DR   Bgee; ENSG00000182685; Expressed in right hemisphere of cerebellum and 96 other tissues.
DR   ExpressionAtlas; Q6PL45; baseline and differential.
DR   Genevisible; Q6PL45; HS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR   InterPro; IPR007084; BRICHOS_dom.
DR   Pfam; PF04089; BRICHOS; 1.
DR   SMART; SM01039; BRICHOS; 1.
DR   PROSITE; PS50869; BRICHOS; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Disulfide bond; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..260
FT                   /note="BRICHOS domain-containing protein 5"
FT                   /id="PRO_0000284046"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..235
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          98..193
FT                   /note="BRICHOS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        79
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        125..185
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         198..229
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_024411"
FT   VARIANT         31
FT                   /note="S -> G (in dbSNP:rs26856)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT                   /id="VAR_061620"
FT   VARIANT         46
FT                   /note="V -> I (in dbSNP:rs26857)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT                   /id="VAR_031629"
FT   VARIANT         122
FT                   /note="H -> Y (in dbSNP:rs58292351)"
FT                   /id="VAR_061621"
FT   CONFLICT        126
FT                   /note="F -> S (in Ref. 1; AAT09004)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   260 AA;  28486 MW;  D3097E3B8298408F CRC64;
     MEPASCCAER PKPGPTGVKT KPSCGGWRAV SLLLLLLLLV LAAVGVVAGG LLGSAQGPPK
     PRLQTLRMTL PSPHMPRPNQ TILVDVARNA ATITVTPPQS NHSWAVLFDG QSGCICYRPE
     EHQVCFLRLM EDSDRETLRL LVDTSKVQEA WVPSQDTHHT QELLAVQGSL EVDPAQAGAL
     VQRLCMRTPI YWARRAEGES GPLWGKARPS GWFEELGAEP LEIHGTLATG PRRQRLIYLC
     IDICFPSNIC VSVCFYYLPD
 
 
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