TH11_TRYBB
ID TH11_TRYBB Reviewed; 527 AA.
AC Q06221;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Glucose transporter 1B/1C/1D/1F/2B;
GN Name=THT1B;
GN and
GN Name=THT1C;
GN and
GN Name=THT1D;
GN and
GN Name=THT1F;
GN and
GN Name=THT2B;
OS Trypanosoma brucei brucei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=5702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=EATRO 164;
RX PubMed=8423781; DOI=10.1128/mcb.13.2.1146-1154.1993;
RA Bringaud F., Baltz T.;
RT "Differential regulation of two distinct families of glucose transporter
RT genes in Trypanosoma brucei.";
RL Mol. Cell. Biol. 13:1146-1154(1993).
CC -!- FUNCTION: Facilitative glucose transporter.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- DEVELOPMENTAL STAGE: Expressed specifically in bloodstream forms.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; X69091; CAA48834.1; -; Genomic_DNA.
DR EMBL; X69091; CAA48835.1; -; Genomic_DNA.
DR EMBL; X69091; CAA48836.1; -; Genomic_DNA.
DR EMBL; X69091; CAA48838.1; -; Genomic_DNA.
DR EMBL; X69091; CAA48840.1; -; Genomic_DNA.
DR AlphaFoldDB; Q06221; -.
DR SMR; Q06221; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR045263; GLUT.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR PANTHER; PTHR23503; PTHR23503; 2.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Membrane; Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..527
FT /note="Glucose transporter 1B/1C/1D/1F/2B"
FT /id="PRO_0000050384"
FT TOPO_DOM 1..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..118
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..175
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..249
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..299
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 321..338
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 394..403
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 425..436
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..457
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 458..475
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 476..496
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 497..527
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 527 AA; 56470 MW; 32E34915A2A12876 CRC64;
MTERRDNVSH APDAIEGPND GAHAEDTSPG FFSLENLGVA QVQVVGGTLN GYVIGYVAVY
LLLYLTATEC KFTTEGACGG RKIYGCKWSG TTCKFENPKC SEGSDPSDSC KNEVAYTSVY
SGIFACAMIV GSMVGSIIAG KCITTFGLKK SFIIVSITCT IACVVVQVAI EYNNYYALCT
GRVLIGLGVG ILCSVFPMYV NENAHPKLCK MDGVLFQVFT TLGIMLAAML GLILDKTGAS
KEEANMAGRL HVFSAVPLGL SVAMFLVGMF LRESTATFAQ DDDGKADGGM DPNEYGWGQM
LWPLFMGAVT AGTLQLTGIN AVMNYAPKIT ENLGMDPSLG NFLVMAWNFV TSLVAIPLAS
RFTMRQMFIT CSFVASCMCL FLCGIPVFPG VAGKEVKNGV ATTGIALFIA AFEFGVGSCF
FVLAQDLFPP SFRPKGGSFV VMMQFIFNIL INLLYPITTE AISGGATGNQ DKGQAVAFIL
FGLIGLICSV LQFFYLYPYD ANQDHENDHG GEPVEQKTYP VEASPRN
