TH12_TRYBB
ID TH12_TRYBB Reviewed; 528 AA.
AC Q09037;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Glucose transporter 1E;
GN Name=THT1E;
OS Trypanosoma brucei brucei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=5702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=EATRO 164;
RX PubMed=8423781; DOI=10.1128/mcb.13.2.1146-1154.1993;
RA Bringaud F., Baltz T.;
RT "Differential regulation of two distinct families of glucose transporter
RT genes in Trypanosoma brucei.";
RL Mol. Cell. Biol. 13:1146-1154(1993).
CC -!- FUNCTION: Facilitative glucose transporter.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- DEVELOPMENTAL STAGE: Expressed specifically in bloodstream forms.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; X69091; CAA48837.1; -; Genomic_DNA.
DR AlphaFoldDB; Q09037; -.
DR SMR; Q09037; -.
DR GO; GO:0051286; C:cell tip; IDA:GeneDB.
DR GO; GO:0016021; C:integral component of membrane; TAS:GeneDB.
DR GO; GO:0005886; C:plasma membrane; IDA:GeneDB.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; IMP:GeneDB.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR045263; GLUT.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR PANTHER; PTHR23503; PTHR23503; 2.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Membrane; Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..528
FT /note="Glucose transporter 1E"
FT /id="PRO_0000050385"
FT TOPO_DOM 1..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..118
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..175
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..250
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..338
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..367
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 389..403
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 425..438
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 460..475
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 476..496
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 497..528
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 528 AA; 56827 MW; A18D2B15EB06F8F4 CRC64;
MTERRDNVSH APDAIEGPND GAHAEETSPG FFSFENLGVA QVQVVGGTLN GYVIGYVAVY
LLLYLTATEC KFTTEGACGG RKIYGCKWSG TTCKFENPKC SEGSDPSDSC KNEVAYTSVY
SGIFACAMIV GSMVGSIIAG KCITTFGLKK SFIIVSITCT IACVVVQVAI EYNNYYALCT
GRVLIGLGVG ILCSVFPMYV NENAHPKLCK MDGVLFQVFT TLGIMLAAML GLILDKTGAS
KEEANMAGRL HVFSAVPLGL SVAMFLVGMF LRESTATFAQ DDDGKADGGM DPNEYGWGQM
LWPLFMGAVT AGTLQLTGIN AVMNYAPKIT ENLGMDPSLG NFLVMAWNFV TSLVAIPLAS
RFTMRQMFIT CSFVASCMCL FLCGIPVFPG VAEEKVKNGV ATTGIALFIA AFEFGVGSCF
FVLAQDLFPP SFRPKGSSFV VMMQFIFNIL INLLYPITTE AISGGATGDQ DKGQAVVFIL
FGLIGLICFV LQFFYLYPYD ANQDHENDHG TEPVERILSP VDVPTPRN
