TH23_TRYBB
ID TH23_TRYBB Reviewed; 337 AA.
AC Q09039;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Glucose transporter 2C;
DE Flags: Fragment;
GN Name=THT2C;
OS Trypanosoma brucei brucei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=5702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=EATRO 164;
RX PubMed=8423781; DOI=10.1128/mcb.13.2.1146-1154.1993;
RA Bringaud F., Baltz T.;
RT "Differential regulation of two distinct families of glucose transporter
RT genes in Trypanosoma brucei.";
RL Mol. Cell. Biol. 13:1146-1154(1993).
CC -!- FUNCTION: Facilitative glucose transporter.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- DEVELOPMENTAL STAGE: Expressed in both bloodstream and procyclic forms.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; X69091; CAA48841.1; -; Genomic_DNA.
DR AlphaFoldDB; Q09039; -.
DR SMR; Q09039; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR045263; GLUT.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR PANTHER; PTHR23503; PTHR23503; 2.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..>337
FT /note="Glucose transporter 2C"
FT /id="PRO_0000050388"
FT TOPO_DOM 1..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..119
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..175
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..214
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..250
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..337
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT NON_TER 337
SQ SEQUENCE 337 AA; 35913 MW; CA21A826A1697508 CRC64;
MTERRDNVSH APDAIEGPND GAHAEDTSPG FFSLENLGVA QVQVVGGTLN GFSIGFVAVY
ILLYEVATNC SLFKTTEACK AVGSYGCEWK DTEVCSWKKE CDSDSDGVNP CESLIGYSSL
YSGIFASAMI VGSMVGSIIA GKCITMFGLK KSFIIVGVMS VVASALNHIS VATNEFWVLC
AGRVLMGIGL GVVCVICPMY VNENAHPKLS KVDGVLFQVF ITFGIMLAAM LGLILDKTVN
YDNDPDMAGR FHGFCAVSSV LSVAMFLVGM FLRESTATFS QDDDGKADGG MDPNEYGWGQ
MLWPLFMGAV TAGTLQLTGI NAVMNYAPKI TENLGMD
