TH2A_TRYBB
ID TH2A_TRYBB Reviewed; 529 AA.
AC Q06222;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Glucose transporter 2A;
GN Name=THT2A;
OS Trypanosoma brucei brucei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=5702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=EATRO 164;
RX PubMed=8423781; DOI=10.1128/mcb.13.2.1146-1154.1993;
RA Bringaud F., Baltz T.;
RT "Differential regulation of two distinct families of glucose transporter
RT genes in Trypanosoma brucei.";
RL Mol. Cell. Biol. 13:1146-1154(1993).
CC -!- FUNCTION: Facilitative glucose transporter.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- DEVELOPMENTAL STAGE: Expressed in both bloodstream and procyclic forms.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; X69091; CAA48839.1; -; Genomic_DNA.
DR AlphaFoldDB; Q06222; -.
DR SMR; Q06222; -.
DR TCDB; 2.A.1.1.18; the major facilitator superfamily (mfs).
DR GO; GO:0016021; C:integral component of membrane; TAS:GeneDB.
DR GO; GO:0015149; F:hexose transmembrane transporter activity; IMP:GeneDB.
DR GO; GO:0008645; P:hexose transmembrane transport; IDA:GeneDB.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR045263; GLUT.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR PANTHER; PTHR23503; PTHR23503; 2.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Membrane; Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..529
FT /note="Glucose transporter 2A"
FT /id="PRO_0000050387"
FT TOPO_DOM 1..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..119
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..175
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..214
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..250
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..339
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 361..368
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 390..404
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 426..439
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 461..476
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 477..497
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 498..529
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 57005 MW; C994F29764BC396E CRC64;
MTERRDNVSH APDAIEGPND GAHAEDTSPG FFSFENLGVA QVQVVGGTLN GFSIGFVAVY
ILLYEVATNC SLFKTTEACK AVGSYGCEWK DTEVCSWKKE CDSDSDGVNP CESLIGYSSL
YSGIFASAMI VGSMVGSIIA GKCITMFGLK KSFIIVGVMS VVASALNHIS VATNEFWVLC
AGRVLMGIGL GVVCVICPMY VNENAHPKLS KVDGVLFQVF ITFGIMLAAM LGLILDKTVN
YDNDPDMAGR FHGFCAVSSV LSVAMFLVGM FLRESTATFS QDDDGKADGG MDPNEYGWGQ
MLWPLFMGAV TAGTLQLTGI NAVMNYAPKI TENLGMDPSL GNFLVMAWNF VTSLVAIPLA
SRFTMRQMFI TCSFVASCMC LFLCGIPVFP GVAEEKVKNG VATTGIALFI AAFEFGVGSC
FFVLAQDLFP PSFRPKGSSF VVMMQFIFNI LINLLYPITT EAISGGATGD QDKGQAVVFI
LFGLIGLICF VLQFFYLYPY DANQDHENDH GTEPVERILS PVDVPTPRN
