THA10_HUMAN
ID THA10_HUMAN Reviewed; 257 AA.
AC Q9P2Z0; B2R8R0;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=THAP domain-containing protein 10;
GN Name=THAP10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG The European IMAGE consortium;
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Substantia nigra;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9P2Z0; O95273: CCNDBP1; NbExp=5; IntAct=EBI-745404, EBI-748961;
CC Q9P2Z0; P63167: DYNLL1; NbExp=8; IntAct=EBI-745404, EBI-349105;
CC Q9P2Z0; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-745404, EBI-10172150;
CC Q9P2Z0; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-745404, EBI-10171774;
CC Q9P2Z0; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-745404, EBI-10172052;
CC Q9P2Z0; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-745404, EBI-741037;
CC Q9P2Z0; Q9Y5B8: NME7; NbExp=3; IntAct=EBI-745404, EBI-744782;
CC Q9P2Z0; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-745404, EBI-742388;
CC Q9P2Z0; P61289: PSME3; NbExp=3; IntAct=EBI-745404, EBI-355546;
CC Q9P2Z0; Q03393: PTS; NbExp=3; IntAct=EBI-745404, EBI-712344;
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DR EMBL; AL360202; CAB96109.1; -; mRNA.
DR EMBL; AK313472; BAG36257.1; -; mRNA.
DR EMBL; CH471082; EAW77863.1; -; Genomic_DNA.
DR EMBL; BC027857; AAH27857.1; -; mRNA.
DR EMBL; BC072414; AAH72414.1; -; mRNA.
DR CCDS; CCDS10237.1; -.
DR RefSeq; NP_064532.1; NM_020147.3.
DR AlphaFoldDB; Q9P2Z0; -.
DR SMR; Q9P2Z0; -.
DR BioGRID; 121236; 31.
DR IntAct; Q9P2Z0; 14.
DR MINT; Q9P2Z0; -.
DR STRING; 9606.ENSP00000249861; -.
DR iPTMnet; Q9P2Z0; -.
DR PhosphoSitePlus; Q9P2Z0; -.
DR BioMuta; THAP10; -.
DR DMDM; 41018369; -.
DR MassIVE; Q9P2Z0; -.
DR MaxQB; Q9P2Z0; -.
DR PaxDb; Q9P2Z0; -.
DR PeptideAtlas; Q9P2Z0; -.
DR PRIDE; Q9P2Z0; -.
DR ProteomicsDB; 83915; -.
DR Antibodypedia; 26487; 74 antibodies from 19 providers.
DR DNASU; 56906; -.
DR Ensembl; ENST00000249861.9; ENSP00000249861.4; ENSG00000129028.9.
DR GeneID; 56906; -.
DR KEGG; hsa:56906; -.
DR MANE-Select; ENST00000249861.9; ENSP00000249861.4; NM_020147.4; NP_064532.1.
DR UCSC; uc002asv.4; human.
DR CTD; 56906; -.
DR DisGeNET; 56906; -.
DR GeneCards; THAP10; -.
DR HGNC; HGNC:23193; THAP10.
DR HPA; ENSG00000129028; Low tissue specificity.
DR MIM; 612538; gene.
DR neXtProt; NX_Q9P2Z0; -.
DR OpenTargets; ENSG00000129028; -.
DR PharmGKB; PA134988462; -.
DR VEuPathDB; HostDB:ENSG00000129028; -.
DR eggNOG; ENOG502SDT3; Eukaryota.
DR GeneTree; ENSGT00510000050001; -.
DR HOGENOM; CLU_094625_0_0_1; -.
DR InParanoid; Q9P2Z0; -.
DR OMA; TQTDELW; -.
DR PhylomeDB; Q9P2Z0; -.
DR TreeFam; TF330127; -.
DR PathwayCommons; Q9P2Z0; -.
DR SignaLink; Q9P2Z0; -.
DR BioGRID-ORCS; 56906; 14 hits in 1091 CRISPR screens.
DR GenomeRNAi; 56906; -.
DR Pharos; Q9P2Z0; Tdark.
DR PRO; PR:Q9P2Z0; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9P2Z0; protein.
DR Bgee; ENSG00000129028; Expressed in bronchial epithelial cell and 154 other tissues.
DR ExpressionAtlas; Q9P2Z0; baseline and differential.
DR Genevisible; Q9P2Z0; HS.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 6.20.210.20; -; 1.
DR InterPro; IPR006612; THAP_Znf.
DR InterPro; IPR038441; THAP_Znf_sf.
DR Pfam; PF05485; THAP; 1.
DR SMART; SM00692; DM3; 1.
DR SMART; SM00980; THAP; 1.
DR PROSITE; PS50950; ZF_THAP; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..257
FT /note="THAP domain-containing protein 10"
FT /id="PRO_0000068651"
FT ZN_FING 1..90
FT /note="THAP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT REGION 154..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 257 AA; 28351 MW; 912602126537AD41 CRC64;
MPARCVAAHC GNTTKSGKSL FRFPKDRAVR LLWDRFVRGC RADWYGGNDR SVICSDHFAP
ACFDVSSVIQ KNLRFSQRLR LVAGAVPTLH RVPAPAPKRG EEGDQAGRLD TRGELQAARH
SEAAPGPVSC TRPRAGKQAA ASQITCENEL VQTQPHADNP SNTVTSVPTH CEEGPVHKST
QISLKRPRHR SVGIQAKVKA FGKRLCNATT QTEELWSRTS SLFDIYSSDS ETDTDWDIKS
EQSDLSYMAV QVKEETC
