ID   THA11_BOVIN             Reviewed;         303 AA.
AC   A5PKF5;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=THAP domain-containing protein 11;
GN   Name=THAP11;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that plays a central role for
CC       embryogenesis and the pluripotency of embryonic stem (ES) cells.
CC       Sequence-specific DNA-binding factor that represses gene expression in
CC       pluripotent ES cells by directly binding to key genetic loci and
CC       recruiting epigenetic modifiers (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via coiled coil domain) with HCFC1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=May be regulated by shuttling of the protein between the cytoplasm
CC       and nucleus. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the THAP11 family. {ECO:0000305}.
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DR   EMBL; BC142469; AAI42470.1; -; mRNA.
DR   RefSeq; NP_001098464.1; NM_001104994.1.
DR   AlphaFoldDB; A5PKF5; -.
DR   BMRB; A5PKF5; -.
DR   SMR; A5PKF5; -.
DR   STRING; 9913.ENSBTAP00000008406; -.
DR   PaxDb; A5PKF5; -.
DR   PRIDE; A5PKF5; -.
DR   GeneID; 539845; -.
DR   KEGG; bta:539845; -.
DR   CTD; 57215; -.
DR   eggNOG; ENOG502QQ1Z; Eukaryota.
DR   HOGENOM; CLU_090879_1_0_1; -.
DR   InParanoid; A5PKF5; -.
DR   OrthoDB; 1177412at2759; -.
DR   TreeFam; TF331359; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR006612; THAP_Znf.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   SMART; SM00980; THAP; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..303
FT                   /note="THAP domain-containing protein 11"
FT                   /id="PRO_0000355148"
FT   ZN_FING         6..64
FT                   /note="THAP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT   REGION          85..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          244..294
FT                   /evidence="ECO:0000255"
FT   MOTIF           232..235
FT                   /note="HCFC1-binding motif (HBM)"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        101..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   303 AA;  33056 MW;  BB371F5D13359F7E CRC64;
     MPGFTCCVPG CYNNSHRDKA LHFYTFPKDA ELRRLWLKNV SRAGVSGCFS TFQPTTGHRL
     CSVHFQGGRK TYTVRVPTIF PLRGVNERKV ARRPAGAAAA RRRQQQQQQQ QQQQQQQQQQ
     QPSPSASTAQ TTQLQPNLVS ASAAVLLTLQ AAVDSSQAPG TVPPVPTTPT GEDVKPIDLT
     VQVEFAAAEG AAAAAAASEL EAATAGLEAA ECPMGPQLVV VGEEGFPDTG SDHSYSLSSG
     TTEEELLRKL NEQRDILALM EVKMKEMKGS IRHLRLTEAK LREELREKDR LLAMAVIRKK
     HGM