ID   THA11_DANRE             Reviewed;         257 AA.
AC   Q6TGZ4; Q6NYT2;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=THAP domain-containing protein 11;
GN   Name=thap11; ORFNames=zgc:65871;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that plays a central role for
CC       embryogenesis and the pluripotency of embryonic stem (ES) cells.
CC       Sequence-specific DNA-binding factor that represses gene expression in
CC       pluripotent ES cells by directly binding to key genetic loci and
CC       recruiting epigenetic modifiers (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6TGZ4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6TGZ4-2; Sequence=VSP_035879;
CC   -!- SIMILARITY: Belongs to the THAP11 family. {ECO:0000305}.
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DR   EMBL; AY398362; AAQ97795.1; -; mRNA.
DR   EMBL; BC056572; AAH56572.1; -; mRNA.
DR   EMBL; BC066471; AAH66471.1; -; mRNA.
DR   RefSeq; NP_998267.1; NM_213102.1. [Q6TGZ4-1]
DR   AlphaFoldDB; Q6TGZ4; -.
DR   SMR; Q6TGZ4; -.
DR   STRING; 7955.ENSDARP00000052341; -.
DR   PaxDb; Q6TGZ4; -.
DR   Ensembl; ENSDART00000052342; ENSDARP00000052341; ENSDARG00000036055. [Q6TGZ4-1]
DR   GeneID; 406390; -.
DR   KEGG; dre:406390; -.
DR   CTD; 57215; -.
DR   ZFIN; ZDB-GENE-040426-2121; thap11.
DR   eggNOG; ENOG502QQ1Z; Eukaryota.
DR   GeneTree; ENSGT00390000006585; -.
DR   HOGENOM; CLU_090879_1_0_1; -.
DR   InParanoid; Q6TGZ4; -.
DR   OMA; NSHRDKD; -.
DR   OrthoDB; 1177412at2759; -.
DR   PhylomeDB; Q6TGZ4; -.
DR   TreeFam; TF331359; -.
DR   PRO; PR:Q6TGZ4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000036055; Expressed in ovary and 28 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR006612; THAP_Znf.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   SMART; SM00980; THAP; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..257
FT                   /note="THAP domain-containing protein 11"
FT                   /id="PRO_0000355149"
FT   ZN_FING         6..64
FT                   /note="THAP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT   COILED          196..251
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         134..136
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15520368"
FT                   /id="VSP_035879"
SQ   SEQUENCE   257 AA;  28728 MW;  7E464599E8687975 CRC64;
     MPGFTCCVPG CYNNSHRDRD LRFYTFPKDP TQREIWLKNI SRAGVSGCFS TFQPTTGHRV
     CSVHFPGGRK TYTIRVPTLF PLRGVNERRS RRGRSRKVSA VVPIITSVVS TANETAPLEE
     DEEEGDIENT TVVQIGQNGQ YIAPVDLTSS GDGSCITAVV SGGEESAVHE SCSVADFALC
     GADHSYSLTT GTTSTELLRK LNEQRDIIAL MEIKMKEMKN TIRQLRVTEA RLQDELRQRE
     QERERLICAN TIIKRKL