ID   THA11_XENLA             Reviewed;         298 AA.
AC   Q6IR68;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=THAP domain-containing protein 11;
GN   Name=thap11;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that plays a central role for
CC       embryogenesis and the pluripotency of embryonic stem (ES) cells.
CC       Sequence-specific DNA-binding factor that represses gene expression in
CC       pluripotent ES cells by directly binding to key genetic loci and
CC       recruiting epigenetic modifiers (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the THAP11 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH71032.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC071032; AAH71032.1; ALT_INIT; mRNA.
DR   RefSeq; XP_018113244.1; XM_018257755.1.
DR   AlphaFoldDB; Q6IR68; -.
DR   SMR; Q6IR68; -.
DR   GeneID; 432088; -.
DR   KEGG; xla:432088; -.
DR   CTD; 432088; -.
DR   Xenbase; XB-GENE-5954813; thap11.L.
DR   OrthoDB; 1177412at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 432088; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR   InterPro; IPR006612; THAP_Znf.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   SMART; SM00980; THAP; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..298
FT                   /note="THAP domain-containing protein 11"
FT                   /id="PRO_0000355150"
FT   ZN_FING         6..64
FT                   /note="THAP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT   COILED          242..283
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   298 AA;  32412 MW;  003C77E279743DCC CRC64;
     MPGFTCCVPG CYSNSHRDKG LHFYTFPKDP ELRCLWLKNV SRGGVSGCFS TFQPTNGHRV
     CSLHFQGGRK SYSIKVPTIF PLRGVNEKRT RRSSTKKRQQ PNYTPAATTV LVTGLPGQEE
     QEVLELTAGG AEMMLLSTTA GMGATITNVE GSSAVIGATI DAMGTAAVER GSVAAPSNLA
     VKLDVGEAHA ISTHFSSDAS HGSHQQLQVV VVGDEPFPSV DCWPSLLGSD HSYSMSSGTT
     TEELLRKLNE QRDIIALMEV KMKEMKSSIK HLKVTEVKLR EELRQKDKDK VSPMIKSN