ID   THA11_XENTR             Reviewed;         296 AA.
AC   A4IGQ8;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=THAP domain-containing protein 11;
GN   Name=thap11;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that plays a central role for
CC       embryogenesis and the pluripotency of embryonic stem (ES) cells.
CC       Sequence-specific DNA-binding factor that represses gene expression in
CC       pluripotent ES cells by directly binding to key genetic loci and
CC       recruiting epigenetic modifiers (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the THAP11 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI35207.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC135206; AAI35207.1; ALT_INIT; mRNA.
DR   RefSeq; XP_002935416.2; XM_002935370.4.
DR   AlphaFoldDB; A4IGQ8; -.
DR   SMR; A4IGQ8; -.
DR   STRING; 8364.ENSXETP00000012777; -.
DR   PaxDb; A4IGQ8; -.
DR   Ensembl; ENSXETT00000012777; ENSXETP00000012777; ENSXETG00000005807.
DR   GeneID; 100037892; -.
DR   KEGG; xtr:100037892; -.
DR   CTD; 57215; -.
DR   Xenbase; XB-GENE-5954792; thap11.
DR   eggNOG; ENOG502QQ1Z; Eukaryota.
DR   HOGENOM; CLU_090879_1_0_1; -.
DR   InParanoid; A4IGQ8; -.
DR   OrthoDB; 1177412at2759; -.
DR   PhylomeDB; A4IGQ8; -.
DR   TreeFam; TF331359; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000005807; Expressed in early embryo and 13 other tissues.
DR   ExpressionAtlas; A4IGQ8; differential.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR006612; THAP_Znf.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   SMART; SM00980; THAP; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..296
FT                   /note="THAP domain-containing protein 11"
FT                   /id="PRO_0000355151"
FT   ZN_FING         6..64
FT                   /note="THAP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT   COILED          240..281
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   296 AA;  32107 MW;  CD999C67D504172D CRC64;
     MPGFTCCVPG CYSNSHRDKG LHFYTFPKDP ELRCLWLKNV SRGGVSGCFS TFQPTNGHRV
     CSLHFQGGRK SYSIKVPTIF PLRGVNEKRT RRSSTKKRQQ PNYTPAATTV LVTGLPGQEE
     QEVLELTAGG AEMMLLGTTA GMGAAIADVE GSSAVMGATI DAMATAAEGG SAAASNIAVK
     LDVGETHAVN THFSTDASHG SHQQLQVVVV GDEPYPSADC WPSPLCSDHS YSMSSGTTTE
     ELLRKLNEQR DIIALMEVKM KEMKSSIKHL KVTEVKLREE LRQKDKDKVS PMIKSN