THAA_PAROL
ID THAA_PAROL Reviewed; 416 AA.
AC Q91241;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Thyroid hormone receptor alpha-A;
DE Short=THR-alpha-A;
DE AltName: Full=Nuclear receptor subfamily 1 group A member 1-A;
GN Name=thra1; Synonyms=nr1a1-a;
OS Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Paralichthyidae;
OC Paralichthys.
OX NCBI_TaxID=8255;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7923940; DOI=10.1002/dvg.1020150409;
RA Yamano K., Araki K., Sekikawa K., Inui Y.;
RT "Cloning of thyroid hormone receptor genes expressed in metamorphosing
RT flounder.";
RL Dev. Genet. 15:378-382(1994).
CC -!- FUNCTION: High affinity receptor for triiodothyronine.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC DNA-binding domain and a C-terminal ligand-binding domain.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D16461; BAA03928.1; -; mRNA.
DR PIR; I51096; I51096.
DR AlphaFoldDB; Q91241; -.
DR SMR; Q91241; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001728; ThyrH_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00546; THYROIDHORMR.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..416
FT /note="Thyroid hormone receptor alpha-A"
FT /id="PRO_0000053436"
FT DOMAIN 169..413
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 59..126
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 59..79
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 97..121
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..58
FT /note="Modulating"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 47678 MW; 1C80AC6403F58EA6 CRC64;
MEPMSNKQDS NSSEGDEKGW PDVPKRKRKN SQCSMKSMSA LSVSVPGYIP SYLEKDEPCV
VCGDKATGYH YRCITCEGCK GFFRRTIQKN LHPSYSCKYE GCCIIDKITR NQCQLCRFKK
CISVGMAMDL VLDDSKRVAK RRLIEENREK RKREEMVRTL QIRPEPDTAE WELIRMATDA
HRHTNAQGSS WKQKRKFLSD DIGQSPMVPT SDGDKVDLEA FSEFTKIMTP AITRVVDFAK
KLPMFSELPC EDQIILLKGC CMEIMSLRAA VRYDPDSETL TLNSEMAVKR EQLKNGGLGV
VSDAIFDLGK ELGQFNLDDT EVALMQAVLL MSSDRSGHQC MEKIEQCQEA YLLAFEHYIN
YRKHNIPHFW PKLLMKVTDL RMIGACHASR FLHMKVECPS ELFPPLFLEV FEDQEV
