ID   THAB_PAROL              Reviewed;         391 AA.
AC   Q91242;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Thyroid hormone receptor alpha-B;
DE            Short=THR-alpha-B;
DE   AltName: Full=Nuclear receptor subfamily 1 group A member 1-B;
GN   Name=thra2; Synonyms=nr1a1-b;
OS   Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Paralichthyidae;
OC   Paralichthys.
OX   NCBI_TaxID=8255;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7923940; DOI=10.1002/dvg.1020150409;
RA   Yamano K., Araki K., Sekikawa K., Inui Y.;
RT   "Cloning of thyroid hormone receptor genes expressed in metamorphosing
RT   flounder.";
RL   Dev. Genet. 15:378-382(1994).
CC   -!- FUNCTION: High affinity receptor for triiodothyronine.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; D16462; BAA03929.1; -; mRNA.
DR   PIR; I51097; I51097.
DR   AlphaFoldDB; Q91242; -.
DR   SMR; Q91242; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001728; ThyrH_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00546; THYROIDHORMR.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..391
FT                   /note="Thyroid hormone receptor alpha-B"
FT                   /id="PRO_0000053437"
FT   DOMAIN          143..388
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        33..100
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         33..53
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         71..95
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..32
FT                   /note="Modulating"
SQ   SEQUENCE   391 AA;  45055 MW;  19FB8631EE63D022 CRC64;
     MAQWPEKEEE EQPMFGEEYT GYIPSYLEKD EPCVVCGDKA TGYHYRCITC EGCKGFFRRT
     IQKNLHPSYS CKYDCCCIID KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRRLIEE
     NRERRKKEEI VKTLQNRPEP TGAEWELIRM VTEAHRHTNA QGAQWKQKRK FLPDKIGQSP
     VAPTSDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS EQLPCEDQII LLKGCCMEIM
     SLRAAMRYDP ESETLTLSGE MAVKREQLKN GGLGVVSDAI FDLGKSLAQF NLDDTEVALL
     QAVLLMSSDR SGLTCMDKIE KCQETYLLAF EHYINYRKHN IPHFWPKLLM KVTDLRMIGA
     CHASRFLHMK VECPNELFPP LFLEVFEDQE V