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THAB_XENLA
ID   THAB_XENLA              Reviewed;         418 AA.
AC   P18115; Q91911;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Thyroid hormone receptor alpha-B;
DE            Short=TRalphaB;
DE   AltName: Full=Nuclear receptor subfamily 1 group A member 1-B;
GN   Name=thra-b; Synonyms=nr1a1-b, thra2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Tadpole;
RX   PubMed=2402492; DOI=10.1073/pnas.87.18.7090;
RA   Yaoita Y., Shi Y.-B., Brown D.D.;
RT   "Xenopus laevis alpha and beta thyroid hormone receptors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:7090-7094(1990).
RN   [2]
RP   ERRATUM OF PUBMED:2402492.
RX   PubMed=2236080; DOI=10.1073/pnas.87.21.8685a;
RA   Yaoita Y., Shi Y.-B., Brown D.D.;
RL   Proc. Natl. Acad. Sci. U.S.A. 87:8684-8684(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], SEQUENCE REVISION TO 133; 144; 165 AND 392,
RP   FUNCTION, SUBUNIT, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Tadpole;
RX   PubMed=8969201; DOI=10.1074/jbc.271.52.33394;
RA   Puzianowska-Kuznicka M., Wong J., Kanamori A., Shi Y.-B.;
RT   "Functional characterization of a mutant thyroid hormone receptor in
RT   Xenopus laevis.";
RL   J. Biol. Chem. 271:33394-33403(1996).
CC   -!- FUNCTION: High affinity receptor for triiodothyronine (T3).
CC       {ECO:0000269|PubMed:2402492, ECO:0000269|PubMed:8969201}.
CC   -!- SUBUNIT: Binds to thyroid hormone receptor element (TRE) weakly as
CC       homodimers and monomers, but binds TRE with much higher affinity as
CC       heterodimers with retinoid X receptors. Can bind DNA as a heterodimer
CC       with either rxra or rxrg. {ECO:0000269|PubMed:8969201}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000305}.
CC   -!- CAUTION: The sequence derived in PubMed:2402492 was probably derived
CC       from a mutant gene and shows poor transcriptional activation and DNA-
CC       binding activity, but is still able to efficiently form heterodimers
CC       with retinoic acid receptors. {ECO:0000305}.
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DR   EMBL; M35344; AAA49970.1; -; mRNA.
DR   EMBL; L76285; AAC38034.1; -; mRNA.
DR   PIR; B36067; B36067.
DR   AlphaFoldDB; P18115; -.
DR   SMR; P18115; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; TAS:UniProtKB.
DR   GO; GO:0046965; F:nuclear retinoid X receptor binding; IPI:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:0070324; F:thyroid hormone binding; IDA:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001728; ThyrH_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00546; THYROIDHORMR.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..418
FT                   /note="Thyroid hormone receptor alpha-B"
FT                   /id="PRO_0000053444"
FT   DOMAIN          171..415
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        61..128
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         61..81
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         99..123
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..60
FT                   /note="Modulating"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        133
FT                   /note="V -> D (in Ref. 1; AAA49970)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        149
FT                   /note="N -> D (in Ref. 1; AAA49970)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        165
FT                   /note="R -> C (in Ref. 1; AAA49970)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        392
FT                   /note="R -> C (in Ref. 1; AAA49970)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   418 AA;  47683 MW;  092F308C423320AA CRC64;
     MDQNLSGLDC LSEPDEKRWP DGKRKRKNSQ CMGKSGMSGD SLVSLPPAGY IPSYLDKDEP
     CVVCSDKATG YHYRCITCEG CKGFFRRTIQ KNLHPSYSCK YDGCCIIDKI TRNQCQLCRF
     KKCIAVGMAM DLVLDDSKRV AKRKLIEENR VRRRKEEMIK TLQQRPEPSS EEWELIRIVT
     EAHRSTNAQG SHWKQRRKFL PEDIGQSPMA SMPDGDKVDL EAFSEFTKII TPAITRVVDF
     AKKLPMFSEL TCEDQIILLK GCCMEIMSLR AAVRYDPDSE TLTLSGEMAV KREQLKNGGL
     GVVSDAIFDL GRSLAAFNLD DTEVALLQAV LLMSSDRTGL ICTDKIEKCQ ETYLLAFEHY
     INHRKHNIPH FWPKLLMKVT DLRMIGACHA SRFLHMKVEC PTELFPPLFL EVFEDQEV
 
 
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