ID   THADA_CANLF             Reviewed;        1948 AA.
AC   A8C750;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Thyroid adenoma-associated protein homolog;
GN   Name=THADA;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=17889454; DOI=10.1016/j.gene.2007.06.029;
RA   Drieschner N., Kerschling S., Soller J.T., Rippe V., Belge G.,
RA   Bullerdiek J., Nimzyk R.;
RT   "A domain of the thyroid adenoma associated gene (THADA) conserved in
RT   vertebrates becomes destroyed by chromosomal rearrangements observed in
RT   thyroid adenomas.";
RL   Gene 403:110-117(2007).
CC   -!- SIMILARITY: Belongs to the THADA family. {ECO:0000305}.
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DR   EMBL; EF222204; ABQ10598.1; -; mRNA.
DR   RefSeq; NP_001103429.1; NM_001109959.1.
DR   RefSeq; XP_005625722.1; XM_005625665.2.
DR   AlphaFoldDB; A8C750; -.
DR   SMR; A8C750; -.
DR   STRING; 9612.ENSCAFP00000003591; -.
DR   PaxDb; A8C750; -.
DR   GeneID; 100126180; -.
DR   KEGG; cfa:100126180; -.
DR   CTD; 63892; -.
DR   eggNOG; KOG1810; Eukaryota.
DR   HOGENOM; CLU_002048_0_0_1; -.
DR   InParanoid; A8C750; -.
DR   OMA; CTSIPEW; -.
DR   OrthoDB; 59905at2759; -.
DR   TreeFam; TF319713; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019442; THADA/TRM732_DUF2428.
DR   Pfam; PF10350; DUF2428; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..1948
FT                   /note="Thyroid adenoma-associated protein homolog"
FT                   /id="PRO_0000344055"
FT   REGION          1924..1948
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          883..915
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1931..1948
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1012
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6YHU6"
FT   MOD_RES         1021
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6YHU6"
FT   MOD_RES         1158
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6YHU6"
SQ   SEQUENCE   1948 AA;  218932 MW;  3FED1751E736C58A CRC64;
     MGVKKKKEMQ VTALTICHQD LETLRFLADV EGKNLASLLL YCVQLTDGVS QIHYVKQIVP
     LLEKADKNGA CDPIIRSCLD ILAGIYLSLS VKNPLKKVLA SSLNGLPEFF LTEAIQSFTS
     RLQEELNTTD LYSYRKVIDN ISSCMENFDL GRAGVNNLLK NVLHFLQKSL IEISEENRKF
     AGNRIVQTQL MNDLLVGTRV SVMLVQKIQD IQRIHLKTSS SPTWQSMCGL LSIFTKFLSD
     DDLLQTIQST SGLAVILFIK AMFHPPEKIP DLISSLLLRS VDCTSIPDWF LNCCRSLCCT
     DVSQSTLLFL CQGTLTMLDW QNGSMDLSGE ALLLNIVHIL FTLSSQIKES TLELFLSRIL
     ASWTNSAIHV LKSSSPSLKN SLNGKSSVVG RLLEYVYTHW EHPLDALRHQ TKIIFRNILQ
     MHQLTKEKSN SEVSGLAADH FICDLTEGLL RLEWHVKGKY TCLGCLVDYI GIGHILALAK
     TIPSQILEVM GDQSLVPYAS DLLETMFRSH KNHLKSQALD STWIDEWHET WVSPLLFILC
     EGNLDQKSYV IDYYLPKLLN CSPESLSYMV KILQTSADAK TGSYNSRGAL GALMACLRTA
     RAHGHLQSAT DTWRNLVSSA RIKQGLIHQH CQVRIDTLGL LCESNRSTEI VSTEEMQWIQ
     FFITYNLNSQ SPGVRQQICS LLKKLFCRIQ ESSQVLYKQE QSRSKHEPEN ELTKQHPSVS
     LQQYKNFMSS ICSHLFEALF PGSSYPTRFS ALTILGSIAE VFPVTEGQVQ AVYQLSHDID
     VGRFQTLMEC FTSTFEEVKI LAFDLLMKLP KTVVQFQDSE KLQGLFQAAL ELSSSTKPYD
     CVTASYLLNF LIWQDVLPSS LFDSLKTQQT ACEDGDKSAI VVERNTLMVI KCLLENLEEE
     VSQAENSLLQ AAASFPLYGR VHCVTGALQR LSLNNLQLVS EWRPVIEKLL LMSYRLSAVV
     SPVIQSSSPE GLIPMDTDSE SASRLQTILN EIQPRDTNDY FTQAKILKEH DSFDLEDLNV
     SVQNIGASAE VKGKERKTCD VTAQMVLVCC WRSMKEVALL LGTLCQLLPM QSVPESSNGL
     LTEEQVKEIG DYFKQHLLQS RHRGAFELAY TGFVKLTEIL NRCPNVSLQK LPEQWLWNVL
     EEIKCSDPSS KLCATRRSAG IPFYIQALLA SEPKKGKMDL LKITMKELIS LAGPTDDSQS
     TVPQVHALNI LRALFRDTRL GENIIPYVAD GAKAAILGFT SPVWAVRNSS TLLFSTLITR
     IFGVKRGKDE LSKKNRMTGS EFFSRFPELY PFLLQQLEAV ANTVDSDTGE LNRHPSMFLL
     LLVLGRLYPS PMDGTYSALS MAPFIPFIMR CGRSPDYRSR EMAARALVPF VMVDEIPTTI
     RTLLAKLPNC TDQRFRQNHI HGTLLQVFHL LQAFTDSKYR LNTYFQQELA DVAVCTRAKL
     WLAERQNPCL VTRAVYIDIL FLLTRCLDKP TKGNQPAVEC LGFWEDVRRI ISGSELITGF
     TYTFTVPGLP QYLQSLTKLA ITTAAVAAQA GEQAGNIPIS FSQLLESSFP EVRLLTLEAL
     LERFSTAALG LGEKGLPPLQ RNMGETFLML AVKENHPECF CKILKILHCM DPSEWLSHMQ
     RCIHLTPKEF LIWTMDIASN ERSEVQSVAL RLASRVIAHH LQMCEETRDS VAPTLKQWVQ
     LVVSSCGEHL PTESRLAAAE ALTSTTPFLL TSPHPVLGLQ DTLALWRCVL TLLQSEEQAV
     RDAATGTVVT AMSQENTCRS TEFAFCQVDA SIALTLALAV LCDLLQQWDQ LALGLPVLLG
     WLLGEDDDFV VHLENTHQVE DYLFEKAEIN FWAETLIFVK YLHEHLLRLL STSSRRPLSP
     ESLRHLRRTA SEQGHLLSQL FRELPPAAEF LKTVEFTRLR IQEERTLACL QLLAFLEGKE
     REDTPVLRAS DSPAEANQFT LAKTETAH