ID   THADA_CHICK             Reviewed;        1930 AA.
AC   A8C754;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Thyroid adenoma-associated protein homolog;
GN   Name=THADA;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=17889454; DOI=10.1016/j.gene.2007.06.029;
RA   Drieschner N., Kerschling S., Soller J.T., Rippe V., Belge G.,
RA   Bullerdiek J., Nimzyk R.;
RT   "A domain of the thyroid adenoma associated gene (THADA) conserved in
RT   vertebrates becomes destroyed by chromosomal rearrangements observed in
RT   thyroid adenomas.";
RL   Gene 403:110-117(2007).
CC   -!- SIMILARITY: Belongs to the THADA family. {ECO:0000305}.
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DR   EMBL; EF222206; ABQ10600.1; -; mRNA.
DR   RefSeq; NP_001103529.2; NM_001110059.2.
DR   STRING; 9031.ENSGALP00000016128; -.
DR   PaxDb; A8C754; -.
DR   PRIDE; A8C754; -.
DR   GeneID; 421398; -.
DR   KEGG; gga:421398; -.
DR   CTD; 63892; -.
DR   VEuPathDB; HostDB:geneid_421398; -.
DR   eggNOG; KOG1810; Eukaryota.
DR   InParanoid; A8C754; -.
DR   OrthoDB; 59905at2759; -.
DR   PhylomeDB; A8C754; -.
DR   PRO; PR:A8C754; -.
DR   Proteomes; UP000000539; Unplaced.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019442; THADA/TRM732_DUF2428.
DR   Pfam; PF10350; DUF2428; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..1930
FT                   /note="Thyroid adenoma-associated protein homolog"
FT                   /id="PRO_0000344059"
SQ   SEQUENCE   1930 AA;  216614 MW;  F2B90569A90F4713 CRC64;
     MVLKKKKKEI QVDAFSLDCQ QLEKLQGFSK AEEQNLASLL LHCAQLSNGI QQIQCIKQIM
     PLVKAMDQNS ACDPMLKACL EILGETYFSL NMKNPLKKVL ASSLNGLPEW FMTLAVQSFV
     CCLREELKTT DVYLYRKVLD NLASCMEDFN LGRASITNLF EEVLQFLQKA LLDIQEENRS
     NNGNRIVQTR LMHDLLMAIK VAMMLVQKLQ ENIQGSLWKN HESFVWQSMC NLLKSSSDFL
     MDETLLQTVQ TTSGLAFILF TKAMYEPAEE LPSLVSDLLC GSRKLASMPA WFVNNCGALC
     TEQLSDSVLL FLCHGALAML DWKSGSMGEN GEKLLLDIAS VLLSLSSELK ESSMATSLSR
     ILAIWTNSAL AALIPDSPNL KVKLNGNSEV VGKLLEYVYT HWEHPLDAVR HQSKLIFRNL
     LQIHRTIIAA SDEKSDPFFA RLTRRLLSLE WHVKGKYASL ACLVECLGTE NILQLDRSIP
     VQILNVMNDQ SLAPYASDLL ETMFTNHKVQ FTSGSQKSTW IDQWHDVWVS PLLQILCEGN
     HDQTTYIIDY YLPKLLRCSP DSLSYMIRIL QASADANLGS WSTRGALGAL MACLRTARAH
     GHLELSNIMS RGLVSTESIK QGLVHQHNQV CIDALGLLCE THRSTEIVSV EEMQLILFFI
     TYNLNSQSPS VRQQICSLLR KLFCRIRESS QVLYKWEQNK TKQELFEDSP KRNPLGILQK
     YQDFLSSLCD RLFEALFPGS SHPTRFSALS ILGSVAEIFS VQKGQEQVFR LDQEINSARV
     RTLIQCFAST FEEVKVLAFE LLMKLRDVVF XLQDSESLDL LFQAAMDLST STKPYDCVTA
     SYLLNFLAYH EDLQHICLGK WIKHNPQMNE DTSVGTVEKN ILAVIKLLLV NVEEEIFQAK
     KSLLQAAASF PMYGRVHCIN GALQQLPLNN LMFVTEWKQI VARLILMSYE LSAVVSPVVQ
     SSSPEGLIPM DIDSETADRL HMILKEIQPQ DTNDYFMQAK MLKEHCKIQS EKLAEHKPME
     NICTEMRGKE SQICDVTAQM VLVCCWRSMK EVSLLLGTLC KLLPTQASSE PSHGLITVEQ
     VKNIGDYFKH HLMQSRHRGA FELAYAGFVQ LTETLSRCNS ESLRKMPEQW LRCVLEEIKS
     CDPSSTLCAT RRSAGIPFYI QALLASEPKK GKMDLLKMTI KELMSLASPS SEPPSAIPQV
     HALNILRALF RDTRLGENIM PYVADGIQAA ILGFTSPIWA VRNSSTLLFS ALITRIFGVK
     RGKDENSKKN RMTGAEFFSR FPSLYPFLLK QLEVVANTLN SEDEELKIHP SLFLLLLILG
     KLYPSPMDGT YSALSMAPFX PFIIRCGHSP VYRSREMSGR ALVPFVMINE VPHTVLSLLK
     GLPDSASLCI RQNNIHGTLL QVSHLLQSYL DSKQLGNSDF EQGLSDIVTC IGSKLWLAKR
     PNPCLVTRAA FLDVLVMLST HLGNSQKQGM QFVEFWEEMN RVISECELMT GIPYLTAVPG
     LVQYLQSITK LVISVLSVTS AADIQSSSSP TAMKIAKPPL SIVHLLHSEF HEVRLLALEA
     VLLWLKKVNA KQIAKEGGVL CLLVDLEGVL LSMTLKEKNL ECFYKVLEIL YNMDLRNVLP
     KIECSIKMNP NEFLTWSLDI MDNSNSTEVR SMALKFASKL VVHLLENHQQ ISEEVLKKWV
     QQLIYFCGDE QETEMLLAAA EVFRSITSLL LISEKLVLGL SDTLAMWKCV ILLLQNEDLV
     VRDAAAEVLQ VAQAEKKSSX GAGFMFRVMN APLALDLAFG TLCEQLQQWG QTCAGIPVLL
     EWLLGDSDPR GGLEPSAPEE DECLFDKGEV NFWAEKLTSA RLLGKHLLLL AQATHLALPD
     GGELDRLCRR AQDQAQLTAR LLTALPPSPE FLKTAEFTKL AIQNEQISLC LKILNLLQSV
     GKGKDGNLKE