THADA_HUMAN
ID THADA_HUMAN Reviewed; 1953 AA.
AC Q6YHU6; A8K1V8; B7WNS6; Q3KR04; Q53RC6; Q53TB2; Q6YHU2; Q6ZU38; Q8IY32;
AC Q8TAU8; Q96I88; Q9BZF7; Q9C096; Q9H6U0; Q9H6W7;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Thyroid adenoma-associated protein;
DE AltName: Full=Gene inducing thyroid adenomas protein;
GN Name=THADA; Synonyms=GITA, KIAA1767;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, AND
RP CHROMOSOMAL TRANSLOCATIONS.
RX PubMed=12955091; DOI=10.1038/sj.onc.1206867;
RA Rippe V., Drieschner N., Meiboom M., Murua Escobar H., Bonk U., Belge G.,
RA Bullerdiek J.;
RT "Identification of a gene rearranged by 2p21 aberrations in thyroid
RT adenomas.";
RL Oncogene 22:6111-6114(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-699.
RC TISSUE=Brain;
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:347-355(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 688-1953 (ISOFORM 3), AND VARIANT ILE-699.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1118-1953 (ISOFORM 1), AND VARIANTS SER-1385
RP AND TYR-1605.
RC TISSUE=Brain, Pancreas, Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1311-1953.
RA Puduvalli V.K., Ridgway L.;
RT "Novel protein interacting with death receptor.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP CHROMOSOMAL TRANSLOCATIONS.
RX PubMed=17889454; DOI=10.1016/j.gene.2007.06.029;
RA Drieschner N., Kerschling S., Soller J.T., Rippe V., Belge G.,
RA Bullerdiek J., Nimzyk R.;
RT "A domain of the thyroid adenoma associated gene (THADA) conserved in
RT vertebrates becomes destroyed by chromosomal rearrangements observed in
RT thyroid adenomas.";
RL Gene 403:110-117(2007).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1161, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1024, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1015, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q6YHU6; Q86V38: ATN1; NbExp=3; IntAct=EBI-2824523, EBI-11954292;
CC Q6YHU6; Q92876: KLK6; NbExp=3; IntAct=EBI-2824523, EBI-2432309;
CC Q6YHU6; Q96CV9: OPTN; NbExp=3; IntAct=EBI-2824523, EBI-748974;
CC Q6YHU6; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-2824523, EBI-739895;
CC Q6YHU6-6; P78424: POU6F2; NbExp=3; IntAct=EBI-12232803, EBI-12029004;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q6YHU6-1; Sequence=Displayed;
CC Name=2; Synonyms=GITA-A2;
CC IsoId=Q6YHU6-2; Sequence=VSP_034731, VSP_034734;
CC Name=3;
CC IsoId=Q6YHU6-3; Sequence=VSP_034735;
CC Name=4;
CC IsoId=Q6YHU6-4; Sequence=VSP_034730;
CC Name=5;
CC IsoId=Q6YHU6-5; Sequence=VSP_034732, VSP_034733;
CC Name=6;
CC IsoId=Q6YHU6-6; Sequence=VSP_054421, VSP_054422;
CC -!- TISSUE SPECIFICITY: Expressed in pancreas, adrenal medulla, thyroid,
CC adrenal cortex, testis, thymus, small intestine and stomach.
CC {ECO:0000269|PubMed:12955091}.
CC -!- DISEASE: Note=Chromosomal aberrations involving THADA have been
CC observed in benign thyroid adenomas. Translocation t(2;3)(p21;p25) and
CC translocation t(2;7)(p21;p15); the sequences derived from chromosomes
CC 3p25 and 7p15 do not appear to include a coding region and the fusion
CC events probably result in truncated THADA proteins.
CC -!- SIMILARITY: Belongs to the THADA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15133.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB15162.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB21858.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY149629; AAO46785.1; -; mRNA.
DR EMBL; AY149633; AAO46789.1; -; mRNA.
DR EMBL; AB051554; BAB21858.2; ALT_INIT; mRNA.
DR EMBL; AK025530; BAB15162.1; ALT_INIT; mRNA.
DR EMBL; AK025445; BAB15133.1; ALT_INIT; mRNA.
DR EMBL; AK126004; BAC86389.1; -; mRNA.
DR EMBL; AK290023; BAF82712.1; -; mRNA.
DR EMBL; AC010883; AAY14994.1; -; Genomic_DNA.
DR EMBL; AC092615; AAX93152.1; -; Genomic_DNA.
DR EMBL; AC092838; AAX93154.1; -; Genomic_DNA.
DR EMBL; AC104138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC007743; AAH07743.1; -; mRNA.
DR EMBL; BC025773; AAH25773.1; -; mRNA.
DR EMBL; BC037990; AAH37990.1; -; mRNA.
DR EMBL; BC105976; AAI05977.1; -; mRNA.
DR EMBL; AF323176; AAK11318.1; -; mRNA.
DR CCDS; CCDS46268.1; -. [Q6YHU6-1]
DR CCDS; CCDS62901.1; -. [Q6YHU6-6]
DR CCDS; CCDS62902.1; -. [Q6YHU6-5]
DR RefSeq; NP_001077422.1; NM_001083953.1. [Q6YHU6-1]
DR RefSeq; NP_001258572.1; NM_001271643.1. [Q6YHU6-5]
DR RefSeq; NP_001258573.1; NM_001271644.1. [Q6YHU6-6]
DR RefSeq; NP_001332854.1; NM_001345925.1. [Q6YHU6-1]
DR RefSeq; NP_071348.3; NM_022065.4. [Q6YHU6-1]
DR RefSeq; XP_006712128.1; XM_006712065.1. [Q6YHU6-3]
DR PDB; 5T6Y; X-ray; 1.76 A; C=796-807.
DR PDBsum; 5T6Y; -.
DR AlphaFoldDB; Q6YHU6; -.
DR SMR; Q6YHU6; -.
DR BioGRID; 121972; 159.
DR IntAct; Q6YHU6; 33.
DR STRING; 9606.ENSP00000385995; -.
DR iPTMnet; Q6YHU6; -.
DR PhosphoSitePlus; Q6YHU6; -.
DR BioMuta; THADA; -.
DR DMDM; 74749519; -.
DR EPD; Q6YHU6; -.
DR jPOST; Q6YHU6; -.
DR MassIVE; Q6YHU6; -.
DR MaxQB; Q6YHU6; -.
DR PaxDb; Q6YHU6; -.
DR PeptideAtlas; Q6YHU6; -.
DR PRIDE; Q6YHU6; -.
DR ProteomicsDB; 67846; -. [Q6YHU6-1]
DR ProteomicsDB; 67847; -. [Q6YHU6-2]
DR ProteomicsDB; 67848; -. [Q6YHU6-3]
DR ProteomicsDB; 67849; -. [Q6YHU6-4]
DR ProteomicsDB; 67850; -. [Q6YHU6-5]
DR ProteomicsDB; 71096; -.
DR Antibodypedia; 47396; 115 antibodies from 21 providers.
DR DNASU; 63892; -.
DR Ensembl; ENST00000402360.6; ENSP00000385441.2; ENSG00000115970.19. [Q6YHU6-5]
DR Ensembl; ENST00000404790.5; ENSP00000384266.1; ENSG00000115970.19. [Q6YHU6-6]
DR Ensembl; ENST00000405006.8; ENSP00000385995.4; ENSG00000115970.19. [Q6YHU6-1]
DR Ensembl; ENST00000405975.7; ENSP00000386088.2; ENSG00000115970.19. [Q6YHU6-1]
DR GeneID; 63892; -.
DR KEGG; hsa:63892; -.
DR MANE-Select; ENST00000405975.7; ENSP00000386088.2; NM_022065.5; NP_071348.3.
DR UCSC; uc002rsw.5; human. [Q6YHU6-1]
DR CTD; 63892; -.
DR DisGeNET; 63892; -.
DR GeneCards; THADA; -.
DR HGNC; HGNC:19217; THADA.
DR HPA; ENSG00000115970; Low tissue specificity.
DR MIM; 611800; gene.
DR neXtProt; NX_Q6YHU6; -.
DR OpenTargets; ENSG00000115970; -.
DR PharmGKB; PA134882460; -.
DR VEuPathDB; HostDB:ENSG00000115970; -.
DR eggNOG; KOG1810; Eukaryota.
DR GeneTree; ENSGT00390000015500; -.
DR HOGENOM; CLU_002048_0_0_1; -.
DR InParanoid; Q6YHU6; -.
DR OMA; CTSIPEW; -.
DR OrthoDB; 59905at2759; -.
DR PhylomeDB; Q6YHU6; -.
DR TreeFam; TF319713; -.
DR PathwayCommons; Q6YHU6; -.
DR Reactome; R-HSA-6782315; tRNA modification in the nucleus and cytosol.
DR SignaLink; Q6YHU6; -.
DR BioGRID-ORCS; 63892; 10 hits in 1077 CRISPR screens.
DR ChiTaRS; THADA; human.
DR GenomeRNAi; 63892; -.
DR Pharos; Q6YHU6; Tbio.
DR PRO; PR:Q6YHU6; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6YHU6; protein.
DR Bgee; ENSG00000115970; Expressed in calcaneal tendon and 189 other tissues.
DR ExpressionAtlas; Q6YHU6; baseline and differential.
DR Genevisible; Q6YHU6; HS.
DR GO; GO:0098554; C:cytoplasmic side of endoplasmic reticulum membrane; ISS:FlyBase.
DR GO; GO:1990845; P:adaptive thermogenesis; ISS:FlyBase.
DR GO; GO:0055088; P:lipid homeostasis; IGI:FlyBase.
DR GO; GO:1901895; P:negative regulation of ATPase-coupled calcium transmembrane transporter activity; ISS:FlyBase.
DR GO; GO:0032471; P:negative regulation of endoplasmic reticulum calcium ion concentration; IMP:FlyBase.
DR GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR019442; THADA/TRM732_DUF2428.
DR Pfam; PF10350; DUF2428; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Chromosomal rearrangement; Coiled coil;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..1953
FT /note="Thyroid adenoma-associated protein"
FT /id="PRO_0000344057"
FT COILED 886..918
FT /evidence="ECO:0000255"
FT MOD_RES 1015
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1024
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 1161
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976"
FT VAR_SEQ 1..1279
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034730"
FT VAR_SEQ 1..290
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12955091"
FT /id="VSP_034731"
FT VAR_SEQ 892..894
FT /note="VIK -> GLY (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054421"
FT VAR_SEQ 895..1953
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054422"
FT VAR_SEQ 937
FT /note="N -> K (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034732"
FT VAR_SEQ 938..1953
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034733"
FT VAR_SEQ 1249..1279
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12955091"
FT /id="VSP_034734"
FT VAR_SEQ 1280..1353
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034735"
FT VARIANT 63
FT /note="E -> G (in dbSNP:rs10210191)"
FT /id="VAR_054070"
FT VARIANT 699
FT /note="V -> I (in dbSNP:rs17031056)"
FT /evidence="ECO:0000269|PubMed:11214970,
FT ECO:0000269|PubMed:14702039"
FT /id="VAR_054071"
FT VARIANT 1187
FT /note="T -> A (in dbSNP:rs7578597)"
FT /id="VAR_054072"
FT VARIANT 1385
FT /note="T -> S (in dbSNP:rs33979934)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_054073"
FT VARIANT 1451
FT /note="P -> S (in dbSNP:rs17334247)"
FT /id="VAR_054074"
FT VARIANT 1605
FT /note="C -> Y (in dbSNP:rs35720761)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_054075"
FT VARIANT 1668
FT /note="C -> R (in dbSNP:rs17030648)"
FT /id="VAR_054076"
FT CONFLICT 245
FT /note="Q -> R (in Ref. 3; BAC86389)"
FT /evidence="ECO:0000305"
FT CONFLICT 1507
FT /note="F -> L (in Ref. 3; BAB15133)"
FT /evidence="ECO:0000305"
FT CONFLICT 1709
FT /note="T -> I (in Ref. 3; BAB15133)"
FT /evidence="ECO:0000305"
FT HELIX 802..805
FT /evidence="ECO:0007829|PDB:5T6Y"
SQ SEQUENCE 1953 AA; 219607 MW; 53099534C8B1D80E CRC64;
MGVKKKKEMQ VAALTICHQD LETLKSFADV EGKNLASLLL HCVQLTDGVS QIHYIKQIVP
LLEKADKNGM CDPTIQSCLD ILAGIYLSLS LKNPLKKVLA SSLNSLPDFF LPEAMHRFTS
RLQEELNTTD LYSYRKVTDN ISSCMENFNL GRASVNNLLK NVLHFLQKSL IEILEENRKC
AGNHIIQTQL MNDLLVGIRV SMMLVQKVQD FQGNLWKTSD SPIWQNMCGL LSIFTKVLSD
DDLLQTVQST SGLAIILFIK TMFHPSEKIP HLISSVLLRS VDCTSVPEWF MSSCRSLCCG
DISQSAVLFL CQGTLAMLDW QNGSMGRSGE ALLLDTAHVL FTLSSQIKEP TLEMFLSRIL
ASWTNSAIQV LESSSPSLTD SLNGNSSIVG RLLEYVYTHW EHPLDALRHQ TKIMFKNLLQ
MHRLTVEGAD FVPDPFFVEL TESLLRLEWH IKGKYTCLGC LVECIGVEHI LAIDKTIPSQ
ILEVMGDQSL VPYASDLLET MFRNHKSHLK SQTAESSWID QWHETWVSPL LFILCEGNLD
QKSYVIDYYL PKLLSYSPES LQYMVKILQT SIDAKTGQEQ SFPSLGSCNS RGALGALMAC
LRIARAHGHL QSATDTWENL VSDARIKQGL IHQHCQVRID TLGLLCESNR STEIVSMEEM
QWIQFFITYN LNSQSPGVRQ QICSLLKKLF CRIQESSQVL YKLEQSKSKR EPENELTKQH
PSVSLQQYKN FMSSICNSLF EALFPGSSYS TRFSALTILG SIAEVFHVPE GRIYTVYQLS
HDIDVGRFQT LMECFTSTFE DVKILAFDLL MKLSKTAVHF QDSGKLQGLF QAALELSTST
KPYDCVTASY LLNFLIWQDA LPSSLSAYLT QQVACDNGDR PAAVVERNTL MVIKCLMENL
EEEVSQAENS LLQAAAAFPM YGRVHCITGA LQKLSLNSLQ LVSEWRPVVE KLLLMSYRLS
TVVSPVIQSS SPEGLIPMDT DSESASRLQM ILNEIQPRDT NDYFNQAKIL KEHDSFDMKD
LNASVVNIDT STEIKGKEVK TCDVTAQMVL VCCWRSMKEV ALLLGMLCQL LPMQPVPESS
DGLLTVEQVK EIGDYFKQHL LQSRHRGAFE LAYTGFVKLT EVLNRCPNVS LQKLPEQWLW
SVLEEIKCSD PSSKLCATRR SAGIPFYIQA LLASEPKKGR MDLLKITMKE LISLAGPTDD
IQSTVPQVHA LNILRALFRD TRLGENIIPY VADGAKAAIL GFTSPVWAVR NSSTLLFSAL
ITRIFGVKRA KDEHSKTNRM TGREFFSRFP ELYPFLLKQL ETVANTVDSD MGEPNRHPSM
FLLLLVLERL YASPMDGTSS ALSMGPFVPF IMRCGHSPVY HSREMAARAL VPFVMIDHIP
NTIRTLLSTL PSCTDQCFRQ NHIHGTLLQV FHLLQAYSDS KHGTNSDFQH ELTDITVCTK
AKLWLAKRQN PCLVTRAVYI DILFLLTCCL NRSAKDNQPV LESLGFWEEV RGIISGSELI
TGFPWAFKVP GLPQYLQSLT RLAIAAVWAA AAKSGERETN VPISFSQLLE SAFPEVRSLT
LEALLEKFLA AASGLGEKGV PPLLCNMGEK FLLLAMKENH PECFCKILKI LHCMDPGEWL
PQTEHCVHLT PKEFLIWTMD IASNERSEIQ SVALRLASKV ISHHMQTCVE NRELIAAELK
QWVQLVILSC EDHLPTESRL AVVEVLTSTT PLFLTNPHPI LELQDTLALW KCVLTLLQSE
EQAVRDAATE TVTTAMSQEN TCQSTEFAFC QVDASIALAL ALAVLCDLLQ QWDQLAPGLP
ILLGWLLGES DDLVACVESM HQVEEDYLFE KAEVNFWAET LIFVKYLCKH LFCLLSKSGW
RPPSPEMLCH LQRMVSEQCH LLSQFFRELP PAAEFVKTVE FTRLRIQEER TLACLRLLAF
LEGKEGEDTL VLSVWDSYAE SRQLTLPRTE AAC
