THADA_MOUSE
ID THADA_MOUSE Reviewed; 1938 AA.
AC A8C756; Q3TDR4; Q3U2L1; Q69ZA8; Q7TPV7; Q8C8S7;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Thyroid adenoma-associated protein homolog;
GN Name=Thada; Synonyms=Kiaa1767;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=17889454; DOI=10.1016/j.gene.2007.06.029;
RA Drieschner N., Kerschling S., Soller J.T., Rippe V., Belge G.,
RA Bullerdiek J., Nimzyk R.;
RT "A domain of the thyroid adenoma associated gene (THADA) conserved in
RT vertebrates becomes destroyed by chromosomal rearrangements observed in
RT thyroid adenomas.";
RL Gene 403:110-117(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 770-1440.
RC TISSUE=Embryo;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1006, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=A8C756-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A8C756-2; Sequence=VSP_034737;
CC Name=3;
CC IsoId=A8C756-3; Sequence=VSP_034736;
CC Name=4;
CC IsoId=A8C756-4; Sequence=VSP_034738, VSP_034739;
CC Name=5;
CC IsoId=A8C756-5; Sequence=VSP_034740;
CC -!- SIMILARITY: Belongs to the THADA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32536.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BAE33129.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE41536.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; EF222207; ABQ10601.1; -; mRNA.
DR EMBL; AK044550; BAC31976.1; -; mRNA.
DR EMBL; AK155218; BAE33129.1; ALT_SEQ; mRNA.
DR EMBL; AK170056; BAE41536.1; ALT_FRAME; mRNA.
DR EMBL; BC052885; AAH52885.1; -; mRNA.
DR EMBL; AK173258; BAD32536.1; ALT_SEQ; mRNA.
DR CCDS; CCDS50198.1; -. [A8C756-1]
DR RefSeq; NP_898842.2; NM_183021.3. [A8C756-1]
DR RefSeq; XP_006524337.2; XM_006524274.3. [A8C756-1]
DR RefSeq; XP_006524339.1; XM_006524276.3. [A8C756-1]
DR RefSeq; XP_017172962.1; XM_017317473.1. [A8C756-1]
DR AlphaFoldDB; A8C756; -.
DR SMR; A8C756; -.
DR BioGRID; 232178; 3.
DR IntAct; A8C756; 1.
DR STRING; 10090.ENSMUSP00000041701; -.
DR iPTMnet; A8C756; -.
DR PhosphoSitePlus; A8C756; -.
DR SwissPalm; A8C756; -.
DR EPD; A8C756; -.
DR MaxQB; A8C756; -.
DR PaxDb; A8C756; -.
DR PeptideAtlas; A8C756; -.
DR PRIDE; A8C756; -.
DR ProteomicsDB; 262908; -. [A8C756-1]
DR ProteomicsDB; 262909; -. [A8C756-2]
DR ProteomicsDB; 262910; -. [A8C756-3]
DR ProteomicsDB; 262911; -. [A8C756-4]
DR ProteomicsDB; 262912; -. [A8C756-5]
DR Antibodypedia; 47396; 115 antibodies from 21 providers.
DR Ensembl; ENSMUST00000047524; ENSMUSP00000041701; ENSMUSG00000024251. [A8C756-1]
DR GeneID; 240174; -.
DR KEGG; mmu:240174; -.
DR UCSC; uc008dsr.2; mouse. [A8C756-3]
DR UCSC; uc008dss.2; mouse. [A8C756-2]
DR UCSC; uc012axy.1; mouse. [A8C756-1]
DR CTD; 63892; -.
DR MGI; MGI:3039623; Thada.
DR VEuPathDB; HostDB:ENSMUSG00000024251; -.
DR eggNOG; KOG1810; Eukaryota.
DR GeneTree; ENSGT00390000015500; -.
DR HOGENOM; CLU_002048_0_0_1; -.
DR InParanoid; A8C756; -.
DR OMA; CTSIPEW; -.
DR OrthoDB; 59905at2759; -.
DR PhylomeDB; A8C756; -.
DR TreeFam; TF319713; -.
DR BioGRID-ORCS; 240174; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Thada; mouse.
DR PRO; PR:A8C756; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; A8C756; protein.
DR Bgee; ENSMUSG00000024251; Expressed in animal zygote and 175 other tissues.
DR Genevisible; A8C756; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:GOC.
DR GO; GO:0055088; P:lipid homeostasis; ISO:MGI.
DR GO; GO:0032471; P:negative regulation of endoplasmic reticulum calcium ion concentration; ISO:MGI.
DR GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR019442; THADA/TRM732_DUF2428.
DR Pfam; PF10350; DUF2428; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..1938
FT /note="Thyroid adenoma-associated protein homolog"
FT /id="PRO_0000344058"
FT COILED 877..909
FT /evidence="ECO:0000255"
FT MOD_RES 1006
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1015
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6YHU6"
FT MOD_RES 1152
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6YHU6"
FT VAR_SEQ 1..1576
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034740"
FT VAR_SEQ 1..1438
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034736"
FT VAR_SEQ 1..1270
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034737"
FT VAR_SEQ 347
FT /note="I -> V (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034738"
FT VAR_SEQ 348..1938
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034739"
FT CONFLICT 1749
FT /note="G -> V (in Ref. 2; BAE33129)"
FT /evidence="ECO:0000305"
FT CONFLICT 1750
FT /note="N -> S (in Ref. 3; AAH52885)"
FT /evidence="ECO:0000305"
FT CONFLICT 1759
FT /note="F -> S (in Ref. 2; BAE33129)"
FT /evidence="ECO:0000305"
FT CONFLICT 1925
FT /note="E -> G (in Ref. 2; BAE33129)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1938 AA; 217289 MW; F1E09CC95E2A2B54 CRC64;
MGVKKKREMQ VAALTVCHQD METLRSFADM EGKNLASLLL HCVQLTDGVS QIHSIKQIVP
LLEKVDKNGV CDPAIQSCLD ILAGIYFSLT LKNPLKKVLA SSLNGLPEVF LTQATHSFTF
HLQEELDTAD LYSYRKVMDN ISSCMENFNL GRASVVNLLK DVLHFLQKSL IEILEENRKF
AGNRIVQTQL MSDLLVGVRV AMTLVQKVQG PQGSLWNDSS SPIWQSMCGL LSIFTKFLND
DDLLQTVEST SGLAVILFIK TMFRPSEKLP GLISSLLLRS AECTSIPEWL MNSCRSLCCT
DVPASTLLFL CQGTLAMLDW QDGSMGPSGE ALLLDIVHVL FTLSSQIKES TLDMFLSRIL
ASWTSSAIQI LESGSSGLKG HLNGDSCVPR RLLEYVYTHW EHPLDALRHQ TKVMFRNLLQ
MHRLTMEGAD LATDPFCLEL TKSLLQLEWH IKGKYACLGC LVETLGIEHI LAIDKTIPSQ
ILEVMGDQSL VPYASDLLET MFKNHKSHLK SQTVTNTWMD KWHETWVFPV LSVLCGGNLD
QRSYVIDYYL PRILNYSPES LHYMVHILQA STDTGTGSCN HRGALGALMA CLRTARAHGH
LQSATQAWEN LVCSARVKQG LIHQHCQVRI DTLGLLCESN RSTEVVSTEE MQWVQFFITY
NLNSQSPGVR QQICSLLKKL FCRIQESSQV LYKLEQRKST PDSENGSIRE QPSVTLQQYK
NFMSSVCNIL FEALFPGSSY STRFSALTIL GSVAEVFPDP EGNIQTVYQL SHDIDAGRYQ
ILMECFTSTF EEVKTLAFDL LMKLSSVTAG QFQDSEKLQD LFQAALELST STKPYDCVTA
SYLLNLLIRQ DALPAVLSAS SPQQLTRGAG ETSAVLERNT LVVIKCLMEN LEDEISQAEN
SLLQAASSFP MYGRVHCITR AFQRLPLNDL RLASEWRPLL GRLLLLSYRL STVVAPVIQS
SSPEGLIPVD TDSASASRLQ LILNEIQPRD TNDYFNHTKI LKECDSFDLE DLSTSVSNID
SSAEVKGKEE KACDVTAQMV LACCWRSMKE VALLLGTLCQ LLPVQPGPES SNVFLTVQQV
KEIGDYFKQH LLQSRHRGAF ELAYTGFVKL TEILNRCSNV SLQKLPEQWL RSVLEEIKGS
DPSSKLCATR RSAGIPFYIQ ALLASEPKKS RMDLLKITMR ELISLALSAD DSKGRVPQVH
ALNILRALFR DTRLGENIIP YVAGGAKAAI LGFTSPVWAV RNSSTLLFSS LITRVFGVKR
GKDEVSKTNR MTGREFFSRF PELYPFLLKQ LETVASTVDS ELGEPDRHPG MFLLLLVLER
LYPSPMDGTS SALSLAPFVP FIIRCGRSPI YRSREMAARA LVPFIMIDQI PSTLCALLNS
LPNSTDQCFR QNHIHGTLLQ VFHLLQAYIT DCRHRTNADF LQELSDVTAC TKAKLWLAMR
QNPCLVTRAV YIDILFLLTN CLDRPEEGKQ TALESLGFWE DVRRIILESE LIKGFPWTFK
VPGLPQYLQS LTKLAIPEVW ASLAEAKGQA TAVPLSFSRL LKSSFPEVRL LALDTLLERA
RSSEQEQKEP LPLLCSMGEE LLLLAMKEDH PGCFCRVLKI LYHLNPSEWL PQTECYAHLS
PKEFLMWSMD IASNDRSEIQ GVALKLASKI IAYRVQSCEK NKDSLAPELR QWVQLVVWSC
GDHLPTASRL AVAEVLTSTA PLFLTSPQPI LELQGTLSLW RCVLTLLQSE EQTVREAATE
IVTTAMSQGN TCQSTEFAFC QVDASIALTL ALAVLCDLLQ QWDQLEPGLP ILLGWLLEEG
DDLEGHVQSP HQGEEEHIFE KSEVNFWAET LTFVKSLCRQ LFHLLCQSGW QSPHSQKLCH
LQRIASEQSH LISQLFRELP LSAEFLKTVE YTRLRIQEER TLAVLRLLAC LEGKEGLRAE
DCPREWRQVM APRTEAAC
