ID   THAP1_DANRE             Reviewed;         225 AA.
AC   Q1JPT7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=THAP domain-containing protein 1;
GN   Name=thap1; ORFNames=zgc:136597;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Intestine;
RA   Mathavan S., Yao F., Wong E., Thoreau H., Nayudu M., Govindarajan K.R.,
RA   Ruan Y., Wei C.;
RT   "Genome institute of Singapore, zebrafish transcriptome characterization.";
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-binding transcription regulator that regulates
CC       endothelial cell proliferation and G1/S cell-cycle progression.
CC       Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence
CC       and acts by modulating expression of pRB-E2F cell-cycle target genes
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the THAP1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI16603.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin.; Evidence={ECO:0000305};
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DR   EMBL; EH532428; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC116602; AAI16603.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001038749.1; NM_001045284.1.
DR   AlphaFoldDB; Q1JPT7; -.
DR   SMR; Q1JPT7; -.
DR   STRING; 7955.ENSDARP00000076434; -.
DR   PaxDb; Q1JPT7; -.
DR   Ensembl; ENSDART00000181692; ENSDARP00000153042; ENSDARG00000059020.
DR   GeneID; 692315; -.
DR   KEGG; dre:692315; -.
DR   CTD; 55145; -.
DR   ZFIN; ZDB-GENE-060519-9; thap1.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000164630; -.
DR   HOGENOM; CLU_076186_2_1_1; -.
DR   InParanoid; Q1JPT7; -.
DR   OMA; LMPPLHT; -.
DR   OrthoDB; 1382095at2759; -.
DR   PhylomeDB; Q1JPT7; -.
DR   TreeFam; TF330127; -.
DR   PRO; PR:Q1JPT7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000059020; Expressed in muscle tissue and 21 other tissues.
DR   ExpressionAtlas; Q1JPT7; baseline.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 6.20.210.20; -; 1.
DR   InterPro; IPR026516; THAP1.
DR   InterPro; IPR006612; THAP_Znf.
DR   InterPro; IPR038441; THAP_Znf_sf.
DR   PANTHER; PTHR46600; PTHR46600; 1.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   SMART; SM00980; THAP; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Coiled coil; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..225
FT                   /note="THAP domain-containing protein 1"
FT                   /id="PRO_0000367843"
FT   ZN_FING         5..57
FT                   /note="THAP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT   COILED          149..196
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   225 AA;  25707 MW;  198E73C1265EA99A CRC64;
     MVQSCSAYGC KNRYQKDRNI SFHKFPLARP EVCVQWVSAM SRRNFKPTKY SNICSQHFTS
     DCFKQECNNR VLKDNAVPSL FTLQTQDPFS ADVCFPLNVC ATAEPLSECF PEQCGLPDGQ
     EAGAVSCPEQ CVPPGGQEAG AVSCDHNYTL EDCVQQKRRV QRLQEQMEKL RRRMKTLQQK
     CRRQERQLER LRANRGPAPL GDRYVILPRE LYEELQGVET IGAVH