ID   THAP1_PONAB             Reviewed;         213 AA.
AC   Q5RCE4;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=THAP domain-containing protein 1;
GN   Name=THAP1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-binding transcription regulator that regulates
CC       endothelial cell proliferation and G1/S cell-cycle progression.
CC       Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence
CC       and acts by modulating expression of pRB-E2F cell-cycle target genes,
CC       including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is
CC       required for the regulation of the transcriptional activity of RRM1.
CC       May also have pro-apoptotic activity by potentiating both serum-
CC       withdrawal and TNF-induced apoptosis (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT
CC       complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts
CC       with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat
CC       domain); the interaction recruits HCFC1 to the RRM1 promoter (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus, PML
CC       body {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the THAP1 family. {ECO:0000305}.
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DR   EMBL; CR858327; CAH90563.1; -; mRNA.
DR   RefSeq; NP_001125299.1; NM_001131827.1.
DR   AlphaFoldDB; Q5RCE4; -.
DR   BMRB; Q5RCE4; -.
DR   SMR; Q5RCE4; -.
DR   Ensembl; ENSPPYT00000055393; ENSPPYP00000031967; ENSPPYG00000034807.
DR   GeneID; 100172198; -.
DR   KEGG; pon:100172198; -.
DR   CTD; 55145; -.
DR   GeneTree; ENSGT00940000159383; -.
DR   InParanoid; Q5RCE4; -.
DR   OrthoDB; 1382095at2759; -.
DR   Proteomes; UP000001595; Chromosome 8.
DR   GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0001935; P:endothelial cell proliferation; ISS:UniProtKB.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006351; P:transcription, DNA-templated; ISS:UniProtKB.
DR   Gene3D; 6.20.210.20; -; 1.
DR   InterPro; IPR026516; THAP1.
DR   InterPro; IPR006612; THAP_Znf.
DR   InterPro; IPR038441; THAP_Znf_sf.
DR   PANTHER; PTHR46600; PTHR46600; 1.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   SMART; SM00980; THAP; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Coiled coil; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..213
FT                   /note="THAP domain-containing protein 1"
FT                   /id="PRO_0000068640"
FT   ZN_FING         5..57
FT                   /note="THAP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT   COILED          139..190
FT                   /evidence="ECO:0000255"
FT   MOTIF           134..137
FT                   /note="HCFC1-binding motif (HBM)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   213 AA;  24944 MW;  F3769B0F4CC56539 CRC64;
     MVQSCSAYGC KNRYDKDKPV SFHKFPLTRP SLCKEWEAAV RRKNFKPTKY SSICSEHFTP
     DCFKRECNNK LLKENAVPTI FLCTEPHDKK EDLLEPQEQL PPPPLPPPVS QVDAAIGLLM
     PPLQTPVNLS VFCDHNYTVE DTMHQRKRIH QLEQQVEKLR KKLKTAQQRC RRQERQLEKL
     KEVVHFQKEK DDVSERGYVI LPNDYFEIVE VPA