ID   THAP1_SALSA             Reviewed;         233 AA.
AC   B5XCB8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=THAP domain-containing protein 1;
GN   Name=thap1;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: DNA-binding transcription regulator that regulates
CC       endothelial cell proliferation and G1/S cell-cycle progression.
CC       Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence
CC       and acts by modulating expression of pRB-E2F cell-cycle target genes
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the THAP1 family. {ECO:0000305}.
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DR   EMBL; BT048687; ACI68488.1; -; mRNA.
DR   RefSeq; NP_001134688.1; NM_001141216.2.
DR   AlphaFoldDB; B5XCB8; -.
DR   SMR; B5XCB8; -.
DR   STRING; 8030.ENSSSAP00000047795; -.
DR   GeneID; 100196187; -.
DR   KEGG; sasa:100196187; -.
DR   CTD; 55145; -.
DR   OMA; LMPPLHT; -.
DR   OrthoDB; 1382095at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa01.
DR   Bgee; ENSSSAG00000048517; Expressed in zone of skin and 15 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   Gene3D; 6.20.210.20; -; 1.
DR   InterPro; IPR026516; THAP1.
DR   InterPro; IPR006612; THAP_Znf.
DR   InterPro; IPR038441; THAP_Znf_sf.
DR   PANTHER; PTHR46600; PTHR46600; 1.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   SMART; SM00980; THAP; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Coiled coil; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..233
FT                   /note="THAP domain-containing protein 1"
FT                   /id="PRO_0000367844"
FT   ZN_FING         5..57
FT                   /note="THAP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT   COILED          152..197
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   233 AA;  27018 MW;  99F3DDDAFC04B704 CRC64;
     MVQSCSAYGC KNRYHKDKNI SFHKFPLARP DVCGKWVAAM RRNNFKPTRY SNICSQHFTK
     DCFKPECNNR VLKENAVPSL FCFSKLQIKA ESLADPFPPE MDFPLTLPSL PLSDTEETQQ
     EIQTETHHTV DPLPLVENLP HSMSISCDHN YTVEDTVQQK KRIEQLEEQL DKLRKKLKTV
     QQKCRRQERQ LKRFKAIGEF QRVNRDPALG EGYVILPKQL YDALKGIEPV EGP