ID   THAP1_XENTR             Reviewed;         225 AA.
AC   Q6DIN8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=THAP domain-containing protein 1;
GN   Name=thap1; ORFNames=TGas105m14.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-binding transcription regulator that regulates
CC       endothelial cell proliferation and G1/S cell-cycle progression.
CC       Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence
CC       and acts by modulating expression of pRB-E2F cell-cycle target genes
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the THAP1 family. {ECO:0000305}.
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DR   EMBL; CR762254; CAJ81990.1; -; mRNA.
DR   EMBL; BC075499; AAH75499.1; -; mRNA.
DR   RefSeq; NP_001006738.1; NM_001006737.1.
DR   AlphaFoldDB; Q6DIN8; -.
DR   SMR; Q6DIN8; -.
DR   PaxDb; Q6DIN8; -.
DR   DNASU; 448407; -.
DR   Ensembl; ENSXETT00000022480; ENSXETP00000022480; ENSXETG00000010197.
DR   GeneID; 448407; -.
DR   KEGG; xtr:448407; -.
DR   CTD; 55145; -.
DR   Xenbase; XB-GENE-1008758; thap1.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_076186_2_1_1; -.
DR   InParanoid; Q6DIN8; -.
DR   OMA; FTADCFK; -.
DR   OrthoDB; 1382095at2759; -.
DR   PhylomeDB; Q6DIN8; -.
DR   TreeFam; TF330127; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000010197; Expressed in ovary and 13 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 6.20.210.20; -; 1.
DR   InterPro; IPR026516; THAP1.
DR   InterPro; IPR006612; THAP_Znf.
DR   InterPro; IPR038441; THAP_Znf_sf.
DR   PANTHER; PTHR46600; PTHR46600; 1.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   SMART; SM00980; THAP; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Coiled coil; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..225
FT                   /note="THAP domain-containing protein 1"
FT                   /id="PRO_0000367847"
FT   ZN_FING         5..57
FT                   /note="THAP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT   COILED          139..194
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   225 AA;  26168 MW;  3B6D8C1A734C062E CRC64;
     MVQSCSAYGC KNRYDKDKPI SFHKFPLKRP LLCRKWEAAV RRADFKPTKY SSICSDHFTA
     DCFKRECNNK LLKDNAVPTI FAHTEIKKKS GKAVKKEQLP AEPEPVPSVP EVDPAIGLLL
     PPLYTPSHIA VICDHNYTVE DTVHQRRRIQ QLEEQVDKLR KKLKIANQKC RRQERSLEKL
     EREVSEYREA KGSGYVIFPG NYYEVLNENE YKELAPEITY KEIIL