THAP2_HUMAN
ID THAP2_HUMAN Reviewed; 228 AA.
AC Q9H0W7; B2R8P3;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=THAP domain-containing protein 2;
GN Name=THAP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP STRUCTURE BY NMR OF 1-86.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the THAP domain of the human THAP domain-containing
RT protein 2.";
RL Submitted (JUN-2006) to the PDB data bank.
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DR EMBL; AL136607; CAB66542.1; -; mRNA.
DR EMBL; AK313452; BAG36240.1; -; mRNA.
DR EMBL; CH471054; EAW97265.1; -; Genomic_DNA.
DR EMBL; BC008358; AAH08358.1; -; mRNA.
DR CCDS; CCDS9001.1; -.
DR RefSeq; NP_113623.1; NM_031435.3.
DR PDB; 2D8R; NMR; -; A=1-86.
DR PDBsum; 2D8R; -.
DR AlphaFoldDB; Q9H0W7; -.
DR BMRB; Q9H0W7; -.
DR SMR; Q9H0W7; -.
DR BioGRID; 123687; 15.
DR ELM; Q9H0W7; -.
DR IntAct; Q9H0W7; 8.
DR MINT; Q9H0W7; -.
DR STRING; 9606.ENSP00000310796; -.
DR iPTMnet; Q9H0W7; -.
DR PhosphoSitePlus; Q9H0W7; -.
DR BioMuta; THAP2; -.
DR DMDM; 29839633; -.
DR jPOST; Q9H0W7; -.
DR MassIVE; Q9H0W7; -.
DR MaxQB; Q9H0W7; -.
DR PaxDb; Q9H0W7; -.
DR PeptideAtlas; Q9H0W7; -.
DR PRIDE; Q9H0W7; -.
DR ProteomicsDB; 80332; -.
DR Antibodypedia; 44377; 71 antibodies from 18 providers.
DR DNASU; 83591; -.
DR Ensembl; ENST00000308086.3; ENSP00000310796.2; ENSG00000173451.7.
DR GeneID; 83591; -.
DR KEGG; hsa:83591; -.
DR MANE-Select; ENST00000308086.3; ENSP00000310796.2; NM_031435.4; NP_113623.1.
DR UCSC; uc001swq.4; human.
DR CTD; 83591; -.
DR GeneCards; THAP2; -.
DR HGNC; HGNC:20854; THAP2.
DR HPA; ENSG00000173451; Low tissue specificity.
DR MIM; 612531; gene.
DR neXtProt; NX_Q9H0W7; -.
DR OpenTargets; ENSG00000173451; -.
DR PharmGKB; PA134886354; -.
DR VEuPathDB; HostDB:ENSG00000173451; -.
DR eggNOG; ENOG502RYEP; Eukaryota.
DR GeneTree; ENSGT00940000161088; -.
DR HOGENOM; CLU_076186_2_2_1; -.
DR InParanoid; Q9H0W7; -.
DR OMA; KHINVSF; -.
DR OrthoDB; 1382095at2759; -.
DR PhylomeDB; Q9H0W7; -.
DR TreeFam; TF330127; -.
DR PathwayCommons; Q9H0W7; -.
DR SignaLink; Q9H0W7; -.
DR BioGRID-ORCS; 83591; 7 hits in 1100 CRISPR screens.
DR EvolutionaryTrace; Q9H0W7; -.
DR GeneWiki; THAP2; -.
DR GenomeRNAi; 83591; -.
DR Pharos; Q9H0W7; Tdark.
DR PRO; PR:Q9H0W7; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9H0W7; protein.
DR Bgee; ENSG00000173451; Expressed in cortical plate and 124 other tissues.
DR ExpressionAtlas; Q9H0W7; baseline and differential.
DR Genevisible; Q9H0W7; HS.
DR GO; GO:0005730; C:nucleolus; IDA:LIFEdb.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 6.20.210.20; -; 1.
DR InterPro; IPR026521; THAP2.
DR InterPro; IPR006612; THAP_Znf.
DR InterPro; IPR038441; THAP_Znf_sf.
DR PANTHER; PTHR47696; PTHR47696; 1.
DR Pfam; PF05485; THAP; 1.
DR SMART; SM00692; DM3; 1.
DR SMART; SM00980; THAP; 1.
DR PROSITE; PS50950; ZF_THAP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Metal-binding; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..228
FT /note="THAP domain-containing protein 2"
FT /id="PRO_0000068642"
FT ZN_FING 1..80
FT /note="THAP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT MOTIF 123..126
FT /note="HCFC1-binding motif (HBM)"
FT /evidence="ECO:0000250"
FT VARIANT 170
FT /note="T -> M (in dbSNP:rs17110155)"
FT /id="VAR_034551"
FT STRAND 7..9
FT /evidence="ECO:0007829|PDB:2D8R"
FT HELIX 29..38
FT /evidence="ECO:0007829|PDB:2D8R"
FT STRAND 47..49
FT /evidence="ECO:0007829|PDB:2D8R"
SQ SEQUENCE 228 AA; 26260 MW; 63D886376BC5CC4E CRC64;
MPTNCAAAGC ATTYNKHINI SFHRFPLDPK RRKEWVRLVR RKNFVPGKHT FLCSKHFEAS
CFDLTGQTRR LKMDAVPTIF DFCTHIKSMK LKSRNLLKKN NSCSPAGPSN LKSNISSQQV
LLEHSYAFRN PMEAKKRIIK LEKEIASLRR KMKTCLQKER RATRRWIKAT CLVKNLEANS
VLPKGTSEHM LPTALSSLPL EDFKILEQDQ QDKTLLSLNL KQTKSTFI
