THAP2_MOUSE
ID THAP2_MOUSE Reviewed; 217 AA.
AC Q9D305;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=THAP domain-containing protein 2;
GN Name=Thap2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK018577; BAB31288.1; -; mRNA.
DR EMBL; AK081303; BAC38189.1; -; mRNA.
DR EMBL; BC027502; AAH27502.1; -; mRNA.
DR CCDS; CCDS24179.1; -.
DR RefSeq; NP_080056.1; NM_025780.4.
DR AlphaFoldDB; Q9D305; -.
DR SMR; Q9D305; -.
DR STRING; 10090.ENSMUSP00000020346; -.
DR iPTMnet; Q9D305; -.
DR PhosphoSitePlus; Q9D305; -.
DR PaxDb; Q9D305; -.
DR PRIDE; Q9D305; -.
DR ProteomicsDB; 263122; -.
DR DNASU; 66816; -.
DR Ensembl; ENSMUST00000218842; ENSMUSP00000151353; ENSMUSG00000020137.
DR GeneID; 66816; -.
DR KEGG; mmu:66816; -.
DR UCSC; uc007hbe.1; mouse.
DR CTD; 83591; -.
DR MGI; MGI:1914066; Thap2.
DR VEuPathDB; HostDB:ENSMUSG00000020137; -.
DR eggNOG; ENOG502RYEP; Eukaryota.
DR GeneTree; ENSGT00940000161088; -.
DR HOGENOM; CLU_076186_2_2_1; -.
DR InParanoid; Q9D305; -.
DR OMA; KHINVSF; -.
DR OrthoDB; 1382095at2759; -.
DR PhylomeDB; Q9D305; -.
DR TreeFam; TF330127; -.
DR BioGRID-ORCS; 66816; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Thap2; mouse.
DR PRO; PR:Q9D305; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9D305; protein.
DR Bgee; ENSMUSG00000020137; Expressed in lacrimal gland and 217 other tissues.
DR ExpressionAtlas; Q9D305; baseline and differential.
DR Genevisible; Q9D305; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 6.20.210.20; -; 1.
DR InterPro; IPR026521; THAP2.
DR InterPro; IPR006612; THAP_Znf.
DR InterPro; IPR038441; THAP_Znf_sf.
DR PANTHER; PTHR47696; PTHR47696; 1.
DR Pfam; PF05485; THAP; 1.
DR SMART; SM00692; DM3; 1.
DR SMART; SM00980; THAP; 1.
DR PROSITE; PS50950; ZF_THAP; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..217
FT /note="THAP domain-containing protein 2"
FT /id="PRO_0000068643"
FT ZN_FING 1..80
FT /note="THAP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT MOTIF 122..125
FT /note="HCFC1-binding motif (HBM)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 217 AA; 24993 MW; AAEFF6549ACEAC74 CRC64;
MPTNCAAAGC AATYNKHINI SFHRFPLDPK RRKEWVRLVR RKNFVPGKHT FLCSKHFEAS
CFDLTGQTRR LKMDAVPTIF DFCTHIKSLK LKSRNLLKTN NSFPPTGPCN LKLNGSQQVL
LEHSYAFRNP MEAKKRIIKL EKEIASLRKK MKTCLQRERR ATRRWIKATC FVKSLEASNM
LPKGISEQIL PTALSNLPLE DLKSLEQDQQ DKTVPIL
