ID   THAP3_BOVIN             Reviewed;         239 AA.
AC   Q0P5B4;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=THAP domain-containing protein 3;
GN   Name=THAP3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal medulla;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a THAP1/THAP3-HCFC1-OGT complex that is required
CC       for the regulation of the transcriptional activity of RRM1.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of a THAP1/THAP3-HCFC1-OGT complex that contains at
CC       least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with
CC       OGT and HCFC1 (via its HBM) (By similarity). {ECO:0000250}.
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DR   EMBL; BC120270; AAI20271.1; -; mRNA.
DR   RefSeq; NP_001068815.1; NM_001075347.1.
DR   AlphaFoldDB; Q0P5B4; -.
DR   SMR; Q0P5B4; -.
DR   STRING; 9913.ENSBTAP00000014893; -.
DR   PaxDb; Q0P5B4; -.
DR   Ensembl; ENSBTAT00000014893; ENSBTAP00000014893; ENSBTAG00000011214.
DR   GeneID; 508138; -.
DR   KEGG; bta:508138; -.
DR   CTD; 90326; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011214; -.
DR   VGNC; VGNC:35822; THAP3.
DR   eggNOG; ENOG502S14P; Eukaryota.
DR   GeneTree; ENSGT00940000162344; -.
DR   HOGENOM; CLU_076186_1_0_1; -.
DR   InParanoid; Q0P5B4; -.
DR   OMA; EMPKSCA; -.
DR   OrthoDB; 1382095at2759; -.
DR   TreeFam; TF330127; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000011214; Expressed in retina and 106 other tissues.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   InterPro; IPR026520; THAP3.
DR   InterPro; IPR006612; THAP_Znf.
DR   PANTHER; PTHR47120; PTHR47120; 1.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   SMART; SM00980; THAP; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..239
FT                   /note="THAP domain-containing protein 3"
FT                   /id="PRO_0000282327"
FT   ZN_FING         1..82
FT                   /note="THAP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT   REGION          88..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           176..179
FT                   /note="HCFC1-binding motif (HBM)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   239 AA;  26880 MW;  75509C0DC32A56AF CRC64;
     MPKSCAARQC CNRYSNRRKQ LTFHRFPFSR PELLKEWVLN IGRGDFEPKQ HTVICSEHFR
     PECFSAFGNR KNLKHNAVPT VFAFQGPPQL VRENTDPTGR SGDATSGERK VLPETGSGEC
     GLGRKMDTTV EVLQLPPEVG GLGAQVPPHT PETSGVPGQP ASPPELKRRL PTQPSDHSYA
     LLDLDTLKKK LFLTLKENEK LRRRLKAQRL VMRRMCSRLR ARLAGRPGLQ ARPRLGQQS