THAP3_MOUSE
ID THAP3_MOUSE Reviewed; 218 AA.
AC Q8BJ25; Q8BII6;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=THAP domain-containing protein 3;
GN Name=Thap3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=20200153; DOI=10.1074/jbc.m109.072579;
RA Mazars R., Gonzalez-de-Peredo A., Cayrol C., Lavigne A.C., Vogel J.L.,
RA Ortega N., Lacroix C., Gautier V., Huet G., Ray A., Monsarrat B.,
RA Kristie T.M., Girard J.P.;
RT "The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and
RT O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias.";
RL J. Biol. Chem. 285:13364-13371(2010).
CC -!- FUNCTION: Component of a THAP1/THAP3-HCFC1-OGT complex that is required
CC for the regulation of the transcriptional activity of RRM1.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of a THAP1/THAP3-HCFC1-OGT complex that contains at
CC least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with
CC OGT and HCFC1 (via its HBM) (By similarity). {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highest levels in heart, liver and kidney. Lower
CC levels in brain and lung. {ECO:0000269|PubMed:20200153}.
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DR EMBL; AK038184; BAC29945.1; -; mRNA.
DR EMBL; AK050740; BAC34401.1; -; mRNA.
DR CCDS; CCDS18982.1; -.
DR RefSeq; NP_780361.2; NM_175152.4.
DR AlphaFoldDB; Q8BJ25; -.
DR SMR; Q8BJ25; -.
DR STRING; 10090.ENSMUSP00000035240; -.
DR jPOST; Q8BJ25; -.
DR PaxDb; Q8BJ25; -.
DR PRIDE; Q8BJ25; -.
DR ProteomicsDB; 258871; -.
DR Antibodypedia; 27449; 60 antibodies from 18 providers.
DR DNASU; 69876; -.
DR Ensembl; ENSMUST00000036680; ENSMUSP00000035240; ENSMUSG00000039759.
DR GeneID; 69876; -.
DR KEGG; mmu:69876; -.
DR UCSC; uc008vyu.2; mouse.
DR CTD; 90326; -.
DR MGI; MGI:1917126; Thap3.
DR VEuPathDB; HostDB:ENSMUSG00000039759; -.
DR eggNOG; ENOG502S14P; Eukaryota.
DR GeneTree; ENSGT00940000162344; -.
DR InParanoid; Q8BJ25; -.
DR OMA; EMPKSCA; -.
DR OrthoDB; 1382095at2759; -.
DR PhylomeDB; Q8BJ25; -.
DR TreeFam; TF330127; -.
DR BioGRID-ORCS; 69876; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Thap3; mouse.
DR PRO; PR:Q8BJ25; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BJ25; protein.
DR Bgee; ENSMUSG00000039759; Expressed in ear vesicle and 216 other tissues.
DR ExpressionAtlas; Q8BJ25; baseline and differential.
DR Genevisible; Q8BJ25; MM.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR InterPro; IPR026520; THAP3.
DR InterPro; IPR006612; THAP_Znf.
DR PANTHER; PTHR47120; PTHR47120; 1.
DR Pfam; PF05485; THAP; 1.
DR SMART; SM00692; DM3; 1.
DR SMART; SM00980; THAP; 1.
DR PROSITE; PS50950; ZF_THAP; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Phosphoprotein; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..218
FT /note="THAP domain-containing protein 3"
FT /id="PRO_0000068645"
FT ZN_FING 1..82
FT /note="THAP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT REGION 97..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 156..159
FT /note="HCFC1-binding motif (HBM)"
FT /evidence="ECO:0000250"
FT MOD_RES 100
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WTV1"
FT CONFLICT 157
FT /note="H -> R (in Ref. 1; BAC34401)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 218 AA; 24627 MW; 5FD62D0594D6E715 CRC64;
MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLREWVLN IGRADFKPKQ HTVICSEHFR
PECFSAFGNR KNLKHNAVPT VFAFQNPTEV CPEVGAGGDS SGRNMDTTLE ELQPPTPEGP
VQQVLPDREA MEATEAAGLP ASPLGLKRPL PGQPSDHSYA LSDLDTLKKK LFLTLKENKR
LRKRLKAQRL LLRRTCGRLR AYREGQPGPR ARRPAQGS
