ID   THAP5_BOVIN             Reviewed;         394 AA.
AC   Q1RMM0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=THAP domain-containing protein 5;
GN   Name=THAP5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has sequence-specific DNA-binding activity and can function
CC       as transcriptional repressor (in vitro). May be a regulator of cell
CC       cycle: THAP5 overexpression in human cell lines causes cell cycle
CC       arrest at G2/M phase. {ECO:0000250|UniProtKB:Q7Z6K1}.
CC   -!- SUBUNIT: Interacts with HTRA2; under apoptotic conditions. Interacts
CC       with ABRAXAS2. {ECO:0000250|UniProtKB:Q7Z6K1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7Z6K1}.
CC   -!- PTM: Cleaved by HTRA2 during apoptosis. {ECO:0000250|UniProtKB:Q7Z6K1}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI14827.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC114826; AAI14827.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001069807.1; NM_001076339.1.
DR   AlphaFoldDB; Q1RMM0; -.
DR   SMR; Q1RMM0; -.
DR   STRING; 9913.ENSBTAP00000029153; -.
DR   PaxDb; Q1RMM0; -.
DR   GeneID; 614615; -.
DR   KEGG; bta:614615; -.
DR   CTD; 168451; -.
DR   eggNOG; ENOG502RYVM; Eukaryota.
DR   HOGENOM; CLU_057257_0_0_1; -.
DR   InParanoid; Q1RMM0; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
DR   InterPro; IPR006612; THAP_Znf.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   SMART; SM00980; THAP; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Coiled coil; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..394
FT                   /note="THAP domain-containing protein 5"
FT                   /id="PRO_0000333816"
FT   ZN_FING         1..84
FT                   /note="THAP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT   REGION          86..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          347..381
FT                   /evidence="ECO:0000255"
FT   MOTIF           320..323
FT                   /note="HCFC1-binding motif (HBM)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   394 AA;  45282 MW;  CDA8789F69D4E5DA CRC64;
     MPRYCAAICC KNRRGRNNKE RKLSFYPFPL HDKERLEKWL KNMKRDSWVP SKYQFLCSDH
     FTPDSLDIRW GIRYLKQTAI PTIFALPEDN QEKDPSKKKS QKKKLKSEKE VCLKAKSEES
     FASNEPKKHP VNTDLLPEHA ELLESSALVK PPDPKAESVQ NNILTLSLVK QGTRKPESIL
     ETSVNQDMGI GGFHTSFENL SSTTITLTTA SSEGIQQPLE TQEVIEITTN HLANPHFTNN
     SVEIKSAQEN PFILSTVTQT VEELNTDKES VIAIFVPTEN SKPAINSFIP APKTVEMEED
     IDIEDSYKDV DYETEVLQIE HSYCRQDVNK EHLWQKVSKL HSKITLLELQ EQQTLGRLKS
     LEALIRQLKQ ENWLSEENVK IIENHFTTYE VTMI