THAP6_HUMAN
ID THAP6_HUMAN Reviewed; 222 AA.
AC Q8TBB0; B4E146; Q5HYJ7; Q5JPC6;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=THAP domain-containing protein 6;
GN Name=THAP6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Testis, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Heart, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TBB0; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-3925505, EBI-10173507;
CC Q8TBB0; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-3925505, EBI-541426;
CC Q8TBB0; Q9NPB3: CABP2; NbExp=3; IntAct=EBI-3925505, EBI-12011224;
CC Q8TBB0; O75031: HSF2BP; NbExp=3; IntAct=EBI-3925505, EBI-7116203;
CC Q8TBB0; Q0VD86: INCA1; NbExp=3; IntAct=EBI-3925505, EBI-6509505;
CC Q8TBB0; Q8WYH8: ING5; NbExp=3; IntAct=EBI-3925505, EBI-488533;
CC Q8TBB0; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-3925505, EBI-2556193;
CC Q8TBB0; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-3925505, EBI-10172290;
CC Q8TBB0; P25791-3: LMO2; NbExp=3; IntAct=EBI-3925505, EBI-11959475;
CC Q8TBB0; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-3925505, EBI-77889;
CC Q8TBB0; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-3925505, EBI-741158;
CC Q8TBB0; Q96CV9: OPTN; NbExp=3; IntAct=EBI-3925505, EBI-748974;
CC Q8TBB0; Q9NRD5: PICK1; NbExp=6; IntAct=EBI-3925505, EBI-79165;
CC Q8TBB0; P20618: PSMB1; NbExp=3; IntAct=EBI-3925505, EBI-372273;
CC Q8TBB0; O14787-2: TNPO2; NbExp=3; IntAct=EBI-3925505, EBI-12076664;
CC Q8TBB0; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-3925505, EBI-10183064;
CC Q8TBB0; Q8N720: ZNF655; NbExp=3; IntAct=EBI-3925505, EBI-625509;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8TBB0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TBB0-2; Sequence=VSP_039072;
CC Name=3;
CC IsoId=Q8TBB0-3; Sequence=VSP_054378;
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DR EMBL; AK303658; BAG64658.1; -; mRNA.
DR EMBL; AK313765; BAG36503.1; -; mRNA.
DR EMBL; AL833350; CAI46111.1; -; mRNA.
DR EMBL; BX647579; CAI46093.1; -; mRNA.
DR EMBL; AC096759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471057; EAX05731.1; -; Genomic_DNA.
DR EMBL; BC022989; AAH22989.1; -; mRNA.
DR CCDS; CCDS3568.1; -. [Q8TBB0-1]
DR CCDS; CCDS82932.1; -. [Q8TBB0-2]
DR RefSeq; NP_001304720.1; NM_001317791.1. [Q8TBB0-2]
DR RefSeq; NP_653322.1; NM_144721.5. [Q8TBB0-1]
DR RefSeq; XP_005262831.1; XM_005262774.3. [Q8TBB0-3]
DR RefSeq; XP_011529968.1; XM_011531666.2. [Q8TBB0-1]
DR RefSeq; XP_011529969.1; XM_011531667.2. [Q8TBB0-1]
DR RefSeq; XP_016863289.1; XM_017007800.1. [Q8TBB0-2]
DR AlphaFoldDB; Q8TBB0; -.
DR SMR; Q8TBB0; -.
DR BioGRID; 127466; 19.
DR ELM; Q8TBB0; -.
DR IntAct; Q8TBB0; 18.
DR STRING; 9606.ENSP00000309007; -.
DR iPTMnet; Q8TBB0; -.
DR PhosphoSitePlus; Q8TBB0; -.
DR BioMuta; THAP6; -.
DR DMDM; 29839572; -.
DR MassIVE; Q8TBB0; -.
DR PaxDb; Q8TBB0; -.
DR PeptideAtlas; Q8TBB0; -.
DR PRIDE; Q8TBB0; -.
DR ProteomicsDB; 73980; -. [Q8TBB0-1]
DR ProteomicsDB; 73981; -. [Q8TBB0-2]
DR Antibodypedia; 24670; 243 antibodies from 13 providers.
DR DNASU; 152815; -.
DR Ensembl; ENST00000311638.7; ENSP00000309007.3; ENSG00000174796.12. [Q8TBB0-1]
DR Ensembl; ENST00000380837.7; ENSP00000370217.3; ENSG00000174796.12. [Q8TBB0-2]
DR Ensembl; ENST00000507556.5; ENSP00000427651.1; ENSG00000174796.12. [Q8TBB0-3]
DR Ensembl; ENST00000514480.1; ENSP00000423720.1; ENSG00000174796.12. [Q8TBB0-1]
DR GeneID; 152815; -.
DR KEGG; hsa:152815; -.
DR MANE-Select; ENST00000311638.7; ENSP00000309007.3; NM_144721.6; NP_653322.1.
DR UCSC; uc003him.4; human. [Q8TBB0-1]
DR CTD; 152815; -.
DR GeneCards; THAP6; -.
DR HGNC; HGNC:23189; THAP6.
DR HPA; ENSG00000174796; Low tissue specificity.
DR MIM; 612535; gene.
DR neXtProt; NX_Q8TBB0; -.
DR OpenTargets; ENSG00000174796; -.
DR PharmGKB; PA134873449; -.
DR VEuPathDB; HostDB:ENSG00000174796; -.
DR eggNOG; ENOG502S349; Eukaryota.
DR GeneTree; ENSGT00940000162692; -.
DR HOGENOM; CLU_076186_3_0_1; -.
DR InParanoid; Q8TBB0; -.
DR OMA; AFCWEYC; -.
DR PhylomeDB; Q8TBB0; -.
DR TreeFam; TF335838; -.
DR PathwayCommons; Q8TBB0; -.
DR SignaLink; Q8TBB0; -.
DR BioGRID-ORCS; 152815; 15 hits in 1100 CRISPR screens.
DR ChiTaRS; THAP6; human.
DR GeneWiki; THAP6; -.
DR GenomeRNAi; 152815; -.
DR Pharos; Q8TBB0; Tdark.
DR PRO; PR:Q8TBB0; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8TBB0; protein.
DR Bgee; ENSG00000174796; Expressed in calcaneal tendon and 173 other tissues.
DR ExpressionAtlas; Q8TBB0; baseline and differential.
DR Genevisible; Q8TBB0; HS.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:LIFEdb.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 6.20.210.20; -; 1.
DR InterPro; IPR006612; THAP_Znf.
DR InterPro; IPR038441; THAP_Znf_sf.
DR Pfam; PF05485; THAP; 1.
DR SMART; SM00692; DM3; 1.
DR SMART; SM00980; THAP; 1.
DR PROSITE; PS50950; ZF_THAP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; DNA-binding; Metal-binding;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..222
FT /note="THAP domain-containing protein 6"
FT /id="PRO_0000068647"
FT ZN_FING 1..89
FT /note="THAP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT COILED 149..194
FT /evidence="ECO:0000255"
FT MOTIF 139..142
FT /note="HCFC1-binding motif (HBM)"
FT /evidence="ECO:0000250"
FT VAR_SEQ 97..138
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_039072"
FT VAR_SEQ 139..220
FT /note="EHSYSVMDSPKKLKHKLDHVIGELEDTKESLRNVLDREKRFQKSLRKTIREL
FT KDECLISQETANRLDTFCWDCCQESIEQDY -> KHRKRKQEQEEEQKPRREKC (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054378"
SQ SEQUENCE 222 AA; 25691 MW; 4E039592D64C50FB CRC64;
MVKCCSAIGC ASRCLPNSKL KGLTFHVFPT DENIKRKWVL AMKRLDVNAA GIWEPKKGDV
LCSRHFKKTD FDRSAPNIKL KPGVIPSIFD SPYHLQGKRE KLHCRKNFTL KTVPATNYNH
HLVGASSCIE EFQSQFIFEH SYSVMDSPKK LKHKLDHVIG ELEDTKESLR NVLDREKRFQ
KSLRKTIREL KDECLISQET ANRLDTFCWD CCQESIEQDY IS
