THAP7_HUMAN
ID THAP7_HUMAN Reviewed; 309 AA.
AC Q9BT49; B2RD97; D3DX40;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=THAP domain-containing protein 7;
GN Name=THAP7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-115.
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT PRO-115.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-115.
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION, INTERACTION WITH CHROMATIN; HDAC3 AND NUCLEAR HORMONE RECEPTOR
RP COREPRESSORS, AND TISSUE SPECIFICITY.
RX PubMed=15561719; DOI=10.1074/jbc.m411675200;
RA Macfarlan T., Kutney S., Altman B., Montross R., Yu J., Chakravarti D.;
RT "Human THAP7 is a chromatin-associated, histone tail-binding protein that
RT represses transcription via recruitment of HDAC3 and nuclear hormone
RT receptor corepressor.";
RL J. Biol. Chem. 280:7346-7358(2005).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Chromatin-associated, histone tail-binding protein that
CC represses transcription via recruitment of HDAC3 and nuclear hormone
CC receptor corepressors. {ECO:0000269|PubMed:15561719}.
CC -!- SUBUNIT: Interacts with HDAC3 and nuclear hormone receptor
CC corepressors. {ECO:0000269|PubMed:15561719}.
CC -!- INTERACTION:
CC Q9BT49; O15084: ANKRD28; NbExp=3; IntAct=EBI-741350, EBI-359567;
CC Q9BT49; P27797: CALR; NbExp=3; IntAct=EBI-741350, EBI-1049597;
CC Q9BT49; O95273: CCNDBP1; NbExp=4; IntAct=EBI-741350, EBI-748961;
CC Q9BT49; Q16543: CDC37; NbExp=3; IntAct=EBI-741350, EBI-295634;
CC Q9BT49; P12830: CDH1; NbExp=3; IntAct=EBI-741350, EBI-727477;
CC Q9BT49; Q15078: CDK5R1; NbExp=3; IntAct=EBI-741350, EBI-746189;
CC Q9BT49; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-741350, EBI-3867333;
CC Q9BT49; Q9BSY9: DESI2; NbExp=3; IntAct=EBI-741350, EBI-12878374;
CC Q9BT49; P36957: DLST; NbExp=3; IntAct=EBI-741350, EBI-351007;
CC Q9BT49; Q92997: DVL3; NbExp=3; IntAct=EBI-741350, EBI-739789;
CC Q9BT49; O95967: EFEMP2; NbExp=3; IntAct=EBI-741350, EBI-743414;
CC Q9BT49; Q13643: FHL3; NbExp=3; IntAct=EBI-741350, EBI-741101;
CC Q9BT49; A1L4K1: FSD2; NbExp=3; IntAct=EBI-741350, EBI-5661036;
CC Q9BT49; Q9H0R8: GABARAPL1; NbExp=3; IntAct=EBI-741350, EBI-746969;
CC Q9BT49; Q08379: GOLGA2; NbExp=4; IntAct=EBI-741350, EBI-618309;
CC Q9BT49; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-741350, EBI-5916454;
CC Q9BT49; P49639: HOXA1; NbExp=3; IntAct=EBI-741350, EBI-740785;
CC Q9BT49; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-741350, EBI-3044087;
CC Q9BT49; Q15323: KRT31; NbExp=6; IntAct=EBI-741350, EBI-948001;
CC Q9BT49; O76011: KRT34; NbExp=3; IntAct=EBI-741350, EBI-1047093;
CC Q9BT49; Q6A162: KRT40; NbExp=3; IntAct=EBI-741350, EBI-10171697;
CC Q9BT49; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-741350, EBI-11749135;
CC Q9BT49; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-741350, EBI-10171774;
CC Q9BT49; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-741350, EBI-11988175;
CC Q9BT49; O95751: LDOC1; NbExp=3; IntAct=EBI-741350, EBI-740738;
CC Q9BT49; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-741350, EBI-739832;
CC Q9BT49; Q9BRK4: LZTS2; NbExp=6; IntAct=EBI-741350, EBI-741037;
CC Q9BT49; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-741350, EBI-746778;
CC Q9BT49; P23508: MCC; NbExp=3; IntAct=EBI-741350, EBI-307531;
CC Q9BT49; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-741350, EBI-10172526;
CC Q9BT49; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-741350, EBI-742948;
CC Q9BT49; Q5JR59-3: MTUS2; NbExp=6; IntAct=EBI-741350, EBI-11522433;
CC Q9BT49; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-741350, EBI-1055945;
CC Q9BT49; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-741350, EBI-945833;
CC Q9BT49; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-741350, EBI-22310682;
CC Q9BT49; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-741350, EBI-741158;
CC Q9BT49; Q8IXK0: PHC2; NbExp=3; IntAct=EBI-741350, EBI-713786;
CC Q9BT49; Q5T6S3: PHF19; NbExp=3; IntAct=EBI-741350, EBI-2339674;
CC Q9BT49; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-741350, EBI-79165;
CC Q9BT49; Q13526: PIN1; NbExp=5; IntAct=EBI-741350, EBI-714158;
CC Q9BT49; Q9UL42: PNMA2; NbExp=3; IntAct=EBI-741350, EBI-302355;
CC Q9BT49; Q01105: SET; NbExp=7; IntAct=EBI-741350, EBI-1053182;
CC Q9BT49; Q01105-2: SET; NbExp=5; IntAct=EBI-741350, EBI-7481343;
CC Q9BT49; Q9UBB9: TFIP11; NbExp=7; IntAct=EBI-741350, EBI-1105213;
CC Q9BT49; Q9BT49: THAP7; NbExp=6; IntAct=EBI-741350, EBI-741350;
CC Q9BT49; Q08117-2: TLE5; NbExp=3; IntAct=EBI-741350, EBI-11741437;
CC Q9BT49; P06753: TPM3; NbExp=3; IntAct=EBI-741350, EBI-355607;
CC Q9BT49; Q13077: TRAF1; NbExp=6; IntAct=EBI-741350, EBI-359224;
CC Q9BT49; Q12933: TRAF2; NbExp=13; IntAct=EBI-741350, EBI-355744;
CC Q9BT49; O00463: TRAF5; NbExp=3; IntAct=EBI-741350, EBI-523498;
CC Q9BT49; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-741350, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
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DR EMBL; CR456343; CAG30229.1; -; mRNA.
DR EMBL; AK315457; BAG37844.1; -; mRNA.
DR EMBL; AC002472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471176; EAX02919.1; -; Genomic_DNA.
DR EMBL; CH471176; EAX02921.1; -; Genomic_DNA.
DR EMBL; BC004346; AAH04346.1; -; mRNA.
DR CCDS; CCDS13787.1; -.
DR RefSeq; NP_001008695.1; NM_001008695.1.
DR RefSeq; NP_085050.2; NM_030573.2.
DR AlphaFoldDB; Q9BT49; -.
DR SMR; Q9BT49; -.
DR BioGRID; 123298; 97.
DR ELM; Q9BT49; -.
DR IntAct; Q9BT49; 73.
DR MINT; Q9BT49; -.
DR STRING; 9606.ENSP00000215742; -.
DR iPTMnet; Q9BT49; -.
DR PhosphoSitePlus; Q9BT49; -.
DR BioMuta; THAP7; -.
DR DMDM; 296452927; -.
DR jPOST; Q9BT49; -.
DR MassIVE; Q9BT49; -.
DR MaxQB; Q9BT49; -.
DR PaxDb; Q9BT49; -.
DR PeptideAtlas; Q9BT49; -.
DR PRIDE; Q9BT49; -.
DR ProteomicsDB; 78951; -.
DR Antibodypedia; 314; 28 antibodies from 11 providers.
DR DNASU; 80764; -.
DR Ensembl; ENST00000215742.9; ENSP00000215742.4; ENSG00000184436.12.
DR Ensembl; ENST00000399133.2; ENSP00000382084.2; ENSG00000184436.12.
DR GeneID; 80764; -.
DR KEGG; hsa:80764; -.
DR MANE-Select; ENST00000215742.9; ENSP00000215742.4; NM_030573.3; NP_085050.2.
DR UCSC; uc002ztr.2; human.
DR CTD; 80764; -.
DR DisGeNET; 80764; -.
DR GeneCards; THAP7; -.
DR HGNC; HGNC:23190; THAP7.
DR HPA; ENSG00000184436; Low tissue specificity.
DR MIM; 609518; gene.
DR neXtProt; NX_Q9BT49; -.
DR OpenTargets; ENSG00000184436; -.
DR PharmGKB; PA134964580; -.
DR VEuPathDB; HostDB:ENSG00000184436; -.
DR eggNOG; ENOG502QT6V; Eukaryota.
DR GeneTree; ENSGT00730000111394; -.
DR HOGENOM; CLU_050704_0_0_1; -.
DR InParanoid; Q9BT49; -.
DR OMA; YPPGPHD; -.
DR OrthoDB; 1382095at2759; -.
DR PhylomeDB; Q9BT49; -.
DR TreeFam; TF335838; -.
DR PathwayCommons; Q9BT49; -.
DR SignaLink; Q9BT49; -.
DR BioGRID-ORCS; 80764; 53 hits in 1100 CRISPR screens.
DR ChiTaRS; THAP7; human.
DR GeneWiki; THAP7; -.
DR GenomeRNAi; 80764; -.
DR Pharos; Q9BT49; Tbio.
DR PRO; PR:Q9BT49; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9BT49; protein.
DR Bgee; ENSG00000184436; Expressed in adenohypophysis and 194 other tissues.
DR Genevisible; Q9BT49; HS.
DR GO; GO:0000785; C:chromatin; IDA:ARUK-UCL.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0031965; C:nuclear membrane; IDA:HPA.
DR GO; GO:0016607; C:nuclear speck; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070742; F:C2H2 zinc finger domain binding; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0140296; F:general transcription initiation factor binding; IDA:ARUK-UCL.
DR GO; GO:0042393; F:histone binding; IDA:ARUK-UCL.
DR GO; GO:0042826; F:histone deacetylase binding; IDA:ARUK-UCL.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0070577; F:lysine-acetylated histone binding; IDA:ARUK-UCL.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035064; F:methylated histone binding; IDA:ARUK-UCL.
DR GO; GO:0106153; F:phosphorylated histone binding; IDA:ARUK-UCL.
DR GO; GO:0047485; F:protein N-terminus binding; IPI:UniProtKB.
DR GO; GO:0001222; F:transcription corepressor binding; IDA:ARUK-UCL.
DR GO; GO:0035067; P:negative regulation of histone acetylation; IDA:ARUK-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:ARUK-UCL.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR026519; THAP7.
DR InterPro; IPR006612; THAP_Znf.
DR PANTHER; PTHR47502; PTHR47502; 1.
DR Pfam; PF05485; THAP; 1.
DR SMART; SM00692; DM3; 1.
DR SMART; SM00980; THAP; 1.
DR PROSITE; PS50950; ZF_THAP; 1.
PE 1: Evidence at protein level;
KW Chromosome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..309
FT /note="THAP domain-containing protein 7"
FT /id="PRO_0000068648"
FT ZN_FING 1..93
FT /note="THAP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT REGION 158..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 229..232
FT /note="HCFC1-binding motif (HBM)"
FT /evidence="ECO:0000250"
FT MOD_RES 162
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 210
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 115
FT /note="A -> P (in dbSNP:rs426938)"
FT /evidence="ECO:0000269|PubMed:15461802,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4"
FT /id="VAR_060277"
SQ SEQUENCE 309 AA; 34414 MW; 7B58685CA759D424 CRC64;
MPRHCSAAGC CTRDTRETRN RGISFHRLPK KDNPRRGLWL ANCQRLDPSG QGLWDPASEY
IYFCSKHFEE DCFELVGISG YHRLKEGAVP TIFESFSKLR RTTKTKGHSY PPGPAEVSRL
RRCRKRCSEG RGPTTPFSPP PPADVTCFPV EEASAPATLP ASPAGRLEPG LSSPFSDLLG
PLGAQADEAG CSAQPSPERQ PSPLEPRPVS PSAYMLRLPP PAGAYIQNEH SYQVGSALLW
KRRAEAALDA LDKAQRQLQA CKRREQRLRL RLTKLQQERA REKRAQADAR QTLKEHVQDF
AMQLSSSMA
