THAP7_MOUSE
ID THAP7_MOUSE Reviewed; 309 AA.
AC Q8VCZ3;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=THAP domain-containing protein 7;
GN Name=Thap7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Chromatin-associated, histone tail-binding protein that
CC represses transcription via recruitment of HDAC3 and nuclear hormone
CC receptor corepressors. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with HDAC3 and nuclear hormone receptor
CC corepressors. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
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DR EMBL; BC018221; AAH18221.1; -; mRNA.
DR CCDS; CCDS28004.1; -.
DR RefSeq; NP_081185.1; NM_026909.2.
DR RefSeq; XP_006522574.1; XM_006522511.3.
DR AlphaFoldDB; Q8VCZ3; -.
DR SMR; Q8VCZ3; -.
DR BioGRID; 213170; 1.
DR IntAct; Q8VCZ3; 2.
DR STRING; 10090.ENSMUSP00000097701; -.
DR PhosphoSitePlus; Q8VCZ3; -.
DR PaxDb; Q8VCZ3; -.
DR PRIDE; Q8VCZ3; -.
DR ProteomicsDB; 263173; -.
DR Antibodypedia; 314; 28 antibodies from 11 providers.
DR DNASU; 69009; -.
DR Ensembl; ENSMUST00000100125; ENSMUSP00000097701; ENSMUSG00000022760.
DR Ensembl; ENSMUST00000231548; ENSMUSP00000156168; ENSMUSG00000022760.
DR GeneID; 69009; -.
DR KEGG; mmu:69009; -.
DR UCSC; uc007yld.1; mouse.
DR CTD; 80764; -.
DR MGI; MGI:1916259; Thap7.
DR VEuPathDB; HostDB:ENSMUSG00000022760; -.
DR eggNOG; ENOG502QT6V; Eukaryota.
DR GeneTree; ENSGT00730000111394; -.
DR HOGENOM; CLU_050704_0_0_1; -.
DR InParanoid; Q8VCZ3; -.
DR OMA; YPPGPHD; -.
DR OrthoDB; 1382095at2759; -.
DR PhylomeDB; Q8VCZ3; -.
DR TreeFam; TF335838; -.
DR BioGRID-ORCS; 69009; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Thap7; mouse.
DR PRO; PR:Q8VCZ3; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8VCZ3; protein.
DR Bgee; ENSMUSG00000022760; Expressed in bone fossa and 254 other tissues.
DR ExpressionAtlas; Q8VCZ3; baseline and differential.
DR Genevisible; Q8VCZ3; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070742; F:C2H2 zinc finger domain binding; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0140296; F:general transcription initiation factor binding; ISO:MGI.
DR GO; GO:0042393; F:histone binding; ISO:MGI.
DR GO; GO:0042826; F:histone deacetylase binding; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0070577; F:lysine-acetylated histone binding; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035064; F:methylated histone binding; ISO:MGI.
DR GO; GO:0106153; F:phosphorylated histone binding; ISO:MGI.
DR GO; GO:0047485; F:protein N-terminus binding; ISO:MGI.
DR GO; GO:0001222; F:transcription corepressor binding; ISO:MGI.
DR GO; GO:0035067; P:negative regulation of histone acetylation; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR026519; THAP7.
DR InterPro; IPR006612; THAP_Znf.
DR PANTHER; PTHR47502; PTHR47502; 1.
DR Pfam; PF05485; THAP; 1.
DR SMART; SM00692; DM3; 1.
DR SMART; SM00980; THAP; 1.
DR PROSITE; PS50950; ZF_THAP; 1.
PE 2: Evidence at transcript level;
KW Chromosome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..309
FT /note="THAP domain-containing protein 7"
FT /id="PRO_0000068649"
FT ZN_FING 1..93
FT /note="THAP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT REGION 176..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 229..232
FT /note="HCFC1-binding motif (HBM)"
FT /evidence="ECO:0000250"
FT MOD_RES 162
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BT49"
FT MOD_RES 210
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BT49"
SQ SEQUENCE 309 AA; 34593 MW; D952896B87CC5F00 CRC64;
MPRHCSAAGC CTRDTRETRN RGISFHRLPK KDNPRRGLWL ANCQRLDPSG QGLWDPTSEY
IYFCSKHFEE NCFELVGISG YHRLKEGAVP TIFESFSKLR RTAKTKGHGY PPGLPDVSRL
RRCRKRCSER QGPTTPFSPP PRADIICFPV EEASAPATLP ASPAVRLDPG LNSPFSDLLG
PLGAQADEAG CSTQPSPEQH PSPLEPQPAS PSAYMLRLPP PAGAYIQNEH SYQVGSALLW
KRRAEAALDA LDKTQRQLQA CKRREQRLRL RLTKLQQERA REKRAQADAR QTLKDHVQDF
AMQLSSSMA
