THAP8_HUMAN
ID THAP8_HUMAN Reviewed; 274 AA.
AC Q8NA92; Q0P5Z7; Q96M21;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=THAP domain-containing protein 8;
GN Name=THAP8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLN-185 AND TRP-189.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-157.
RC TISSUE=Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NA92; Q13287: NMI; NbExp=3; IntAct=EBI-717429, EBI-372942;
CC Q8NA92; Q9UBB9: TFIP11; NbExp=5; IntAct=EBI-717429, EBI-1105213;
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DR EMBL; AK057453; BAB71493.1; -; mRNA.
DR EMBL; AK093048; BAC04034.1; -; mRNA.
DR EMBL; BC046207; AAH46207.1; -; mRNA.
DR EMBL; BC072416; AAH72416.1; -; mRNA.
DR CCDS; CCDS33000.1; -.
DR RefSeq; NP_689871.1; NM_152658.2.
DR AlphaFoldDB; Q8NA92; -.
DR SMR; Q8NA92; -.
DR BioGRID; 128269; 31.
DR IntAct; Q8NA92; 11.
DR STRING; 9606.ENSP00000292894; -.
DR iPTMnet; Q8NA92; -.
DR PhosphoSitePlus; Q8NA92; -.
DR BioMuta; THAP8; -.
DR DMDM; 29839559; -.
DR MassIVE; Q8NA92; -.
DR MaxQB; Q8NA92; -.
DR PaxDb; Q8NA92; -.
DR PeptideAtlas; Q8NA92; -.
DR PRIDE; Q8NA92; -.
DR ProteomicsDB; 72658; -.
DR Antibodypedia; 29671; 112 antibodies from 16 providers.
DR DNASU; 199745; -.
DR Ensembl; ENST00000292894.2; ENSP00000292894.1; ENSG00000161277.11.
DR GeneID; 199745; -.
DR KEGG; hsa:199745; -.
DR MANE-Select; ENST00000292894.2; ENSP00000292894.1; NM_152658.3; NP_689871.1.
DR UCSC; uc002oda.1; human.
DR CTD; 199745; -.
DR DisGeNET; 199745; -.
DR GeneCards; THAP8; -.
DR HGNC; HGNC:23191; THAP8.
DR HPA; ENSG00000161277; Low tissue specificity.
DR MIM; 612536; gene.
DR neXtProt; NX_Q8NA92; -.
DR OpenTargets; ENSG00000161277; -.
DR PharmGKB; PA134973337; -.
DR VEuPathDB; HostDB:ENSG00000161277; -.
DR eggNOG; ENOG502S78S; Eukaryota.
DR GeneTree; ENSGT00940000163335; -.
DR HOGENOM; CLU_089335_0_0_1; -.
DR InParanoid; Q8NA92; -.
DR OMA; RCQERHQ; -.
DR OrthoDB; 1382095at2759; -.
DR PhylomeDB; Q8NA92; -.
DR TreeFam; TF330127; -.
DR PathwayCommons; Q8NA92; -.
DR SignaLink; Q8NA92; -.
DR BioGRID-ORCS; 199745; 12 hits in 1093 CRISPR screens.
DR GenomeRNAi; 199745; -.
DR Pharos; Q8NA92; Tdark.
DR PRO; PR:Q8NA92; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NA92; protein.
DR Bgee; ENSG00000161277; Expressed in pancreatic ductal cell and 109 other tissues.
DR ExpressionAtlas; Q8NA92; baseline and differential.
DR Genevisible; Q8NA92; HS.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR026522; THAP8.
DR InterPro; IPR006612; THAP_Znf.
DR PANTHER; PTHR46927:SF2; PTHR46927:SF2; 1.
DR Pfam; PF05485; THAP; 1.
DR SMART; SM00692; DM3; 1.
DR SMART; SM00980; THAP; 1.
DR PROSITE; PS50950; ZF_THAP; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..274
FT /note="THAP domain-containing protein 8"
FT /id="PRO_0000068650"
FT ZN_FING 1..85
FT /note="THAP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT REGION 83..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..121
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 70
FT /note="R -> H (in dbSNP:rs3810449)"
FT /id="VAR_034552"
FT VARIANT 112
FT /note="K -> R (in dbSNP:rs3810450)"
FT /id="VAR_020264"
FT VARIANT 157
FT /note="P -> S (in dbSNP:rs34250145)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034553"
FT VARIANT 185
FT /note="R -> Q (in dbSNP:rs10421966)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_052288"
FT VARIANT 189
FT /note="R -> W (in dbSNP:rs10420353)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_052289"
SQ SEQUENCE 274 AA; 30082 MW; ED820002E426E81A CRC64;
MPKYCRAPNC SNTAGRLGAD NRPVSFYKFP LKDGPRLQAW LQHMGCEHWV PSCHQHLCSE
HFTPSCFQWR WGVRYLRPDA VPSIFSRGPP AKSQRRTRST QKPVSPPPPL QKNTPLPQSP
AIPVSGPVRL VVLGPTSGSP KTVATMLLTP LAPAPTPERS QPEVPAQQAQ TGLGPVLGAL
QRRVRRLQRC QERHQAQLQA LERLAQQLHG ESLLARARRG LQRLTTAQTL GPEESQTFTI
ICGGPDIAMV LAQDPAPATV DAKPELLDTR IPSA
