ID   THA_ELECQ               Reviewed;          71 AA.
AC   Q9PUA8;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Thyroid hormone receptor alpha;
DE   AltName: Full=Nuclear receptor subfamily 1 group A member 1;
DE   Flags: Fragment;
GN   Name=THRA; Synonyms=NR1A1;
OS   Eleutherodactylus coqui (Puerto Rican coqui).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Eleutherodactylidae;
OC   Eleutherodactylinae; Eleutherodactylus; Eleutherodactylus.
OX   NCBI_TaxID=57060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10706622; DOI=10.1073/pnas.050501097;
RA   Callery E.M., Elinson R.P.;
RT   "Thyroid hormone-dependent metamorphosis in a direct developing frog.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:2615-2620(2000).
CC   -!- FUNCTION: Nuclear hormone receptor that can act as a repressor or
CC       activator of transcription. High affinity receptor for thyroid
CC       hormones, including triiodothyronine and thyroxine.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF201957; AAF08312.1; -; mRNA.
DR   AlphaFoldDB; Q9PUA8; -.
DR   SMR; Q9PUA8; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0070324; F:thyroid hormone binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR001728; ThyrH_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00546; THYROIDHORMR.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           <1..>71
FT                   /note="Thyroid hormone receptor alpha"
FT                   /id="PRO_0000053440"
FT   DNA_BIND        <1..22
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         <1..17
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          48..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         71
SQ   SEQUENCE   71 AA;  8633 MW;  2404E459AD560F31 CRC64;
     IDKITRNQCQ LCRFKKCIAV GMAMDLVLDD SKRVAKRKLI EENRERRRKE EMIKTMQQRP
     EPNSEEWELI R