ID   THA_ONCMY               Reviewed;         218 AA.
AC   Q9W6I9;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Thyroid hormone receptor alpha;
DE   AltName: Full=Nuclear receptor subfamily 1 group A member 1;
DE   Flags: Fragment;
GN   Name=thra; Synonyms=nr1a1;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Jones I., Sweeney G.E., Kille P., Wigham T.;
RT   "Cloning and characterisation of a rainbow trout thyroid hormone
RT   receptor.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nuclear hormone receptor that can act as a repressor or
CC       activator of transcription. High affinity receptor for thyroid
CC       hormones, including triiodothyronine and thyroxine.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AH007700; AAD30058.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9W6I9; -.
DR   SMR; Q9W6I9; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004879; F:nuclear receptor activity; ISS:UniProtKB.
DR   GO; GO:0070324; F:thyroid hormone binding; ISS:UniProtKB.
DR   Gene3D; 1.10.565.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001728; ThyrH_rcpt.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00546; THYROIDHORMR.
DR   SMART; SM00430; HOLI; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           <1..218
FT                   /note="Thyroid hormone receptor alpha"
FT                   /id="PRO_0000053435"
FT   DOMAIN          <1..215
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   BINDING         36
FT                   /ligand="3,3',5-triiodo-L-thyronine"
FT                   /ligand_id="ChEBI:CHEBI:533015"
FT                   /evidence="ECO:0000250|UniProtKB:P10827"
FT   BINDING         85
FT                   /ligand="3,3',5-triiodo-L-thyronine"
FT                   /ligand_id="ChEBI:CHEBI:533015"
FT                   /evidence="ECO:0000250|UniProtKB:P10827"
FT   NON_TER         1
SQ   SEQUENCE   218 AA;  24485 MW;  8BD754F1866559D7 CRC64;
     PEDIGQSPGV PTPDGDKVDL EAFSEFTKII TPAITRVVDF AKKLPMFSEL PCEDQIILLK
     GCCMEIMSLR AAVRYDPESE TLTLSGEMAV KREQLKNGGL GVVSDAIFDL GKSLAQFNLD
     DSEVALLQAV LLMSSDRSGL TSVDKIEKCQ ETYLLAFEHY INHRKHNIPH FWPKLLMKVT
     DLRMIGACHA SRFLHMKVEC PNELFPPLFL EVFEDQEV