THBB_XENLA
ID THBB_XENLA Reviewed; 414 AA.
AC P18119; P18118;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Thyroid hormone receptor beta-B;
DE Short=TRbetaB;
DE AltName: Full=Nuclear receptor subfamily 1 group A member 2-B;
GN Name=thrb-b; Synonyms=nr1a2-b, thrb2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BETA-B1 AND BETA-B2), DEVELOPMENTAL
RP STAGE, AND INDUCTION.
RC TISSUE=Tadpole;
RX PubMed=2402492; DOI=10.1073/pnas.87.18.7090;
RA Yaoita Y., Shi Y.-B., Brown D.D.;
RT "Xenopus laevis alpha and beta thyroid hormone receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:7090-7094(1990).
RN [2]
RP ERRATUM OF PUBMED:2402492.
RX PubMed=2236080; DOI=10.1073/pnas.87.21.8685a;
RA Yaoita Y., Shi Y.-B., Brown D.D.;
RL Proc. Natl. Acad. Sci. U.S.A. 87:8684-8684(1990).
CC -!- FUNCTION: High affinity receptor for triiodothyronine (T3).
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Comment=Additional isoforms seem to exist.;
CC Name=Beta-B2; Synonyms=BetaB-II;
CC IsoId=P18119-1; Sequence=Displayed;
CC Name=Beta-B1; Synonyms=BetaB-I;
CC IsoId=P18119-2; Sequence=VSP_003628;
CC -!- DEVELOPMENTAL STAGE: Expression peaks at the climax of metamorphosis.
CC {ECO:0000269|PubMed:2402492}.
CC -!- INDUCTION: By thyroid hormone. {ECO:0000269|PubMed:2402492}.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC DNA-binding domain and a C-terminal ligand-binding domain.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000305}.
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DR EMBL; M35362; AAA49658.1; -; mRNA.
DR EMBL; M35361; AAA49657.1; -; mRNA.
DR PIR; D36067; D36067.
DR RefSeq; NP_001081250.1; NM_001087781.1. [P18119-1]
DR RefSeq; XP_018124099.1; XM_018268610.1. [P18119-1]
DR RefSeq; XP_018124100.1; XM_018268611.1.
DR AlphaFoldDB; P18119; -.
DR SMR; P18119; -.
DR GeneID; 397734; -.
DR KEGG; xla:397734; -.
DR CTD; 397734; -.
DR Xenbase; XB-GENE-6252616; thrb.S.
DR Proteomes; UP000186698; Chromosome 6S.
DR Bgee; 397734; Expressed in internal ear and 8 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; TAS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001728; ThyrH_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00546; THYROIDHORMR.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..414
FT /note="Thyroid hormone receptor beta-B"
FT /id="PRO_0000053459"
FT DOMAIN 170..414
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 60..134
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 60..80
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 98..122
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..59
FT /note="Modulating"
FT VAR_SEQ 7..46
FT /note="Missing (in isoform Beta-B1)"
FT /evidence="ECO:0000303|PubMed:2402492"
FT /id="VSP_003628"
SQ SEQUENCE 414 AA; 46706 MW; F136F8380B2494BE CRC64;
MPSSMSVRLF TASAAQRKKI QEGDCCVVLA GKTQGRFILI GAVARVSGYI PSYLDKDELC
VVCGDKATGY HYRCITCEGC KGFFRRTIQK NLHPSYSCKY EGKCVIDKVT RNQCQECRFK
KCKTVGMATD LVLDDSKRLA KRKLIEENRE KRRKDEIQKS IVQRPEPTQE EWELIQVVTE
AHVATNAQGS HWKQKRKFLP EDIGQAPIVN APEGGKVDLE AFSQFTKIIT PAITRVVDFA
KKLPMFCELP CEDQIILLKG CCMEIMSLRA AVRYDPESET LTLNGEMAVT RGQLKNGGLG
VVSDAIFDLG VSLSSFSLDD TEVALLQAVL LMSSDRPGLS SVERIEKCQE GFLLAFEHYI
NYRKHNIAHF WPKLLMKVTD LRMIGACHAS RFLHMKVECP TELFPPLFLE VFED
