ID   THBG_BOVIN              Reviewed;         411 AA.
AC   Q9TT36;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Thyroxine-binding globulin;
DE   AltName: Full=Serpin A7;
DE   AltName: Full=T4-binding globulin;
DE   Flags: Precursor;
GN   Name=SERPINA7; Synonyms=TBG;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11850119; DOI=10.1016/s0303-7207(01)00679-7;
RA   Janssen O.E., Lahner H., Grasberger H., Spring S.A., Saller B., Mann K.,
RA   Refetoff S., Einspanier R.;
RT   "Characterization and primary structures of bovine and porcine thyroxine-
RT   binding globulin.";
RL   Mol. Cell. Endocrinol. 186:27-35(2002).
CC   -!- FUNCTION: Major thyroid hormone transport protein in serum.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR   EMBL; AF204928; AAF15301.1; -; mRNA.
DR   RefSeq; NP_777093.1; NM_174668.2.
DR   AlphaFoldDB; Q9TT36; -.
DR   SMR; Q9TT36; -.
DR   STRING; 9913.ENSBTAP00000054393; -.
DR   MEROPS; I04.955; -.
DR   PaxDb; Q9TT36; -.
DR   PRIDE; Q9TT36; -.
DR   GeneID; 282518; -.
DR   KEGG; bta:282518; -.
DR   CTD; 6906; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   InParanoid; Q9TT36; -.
DR   OrthoDB; 1124079at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..411
FT                   /note="Thyroxine-binding globulin"
FT                   /id="PRO_0000032435"
FT   BINDING         291
FT                   /ligand="thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:305790"
FT                   /evidence="ECO:0000250"
FT   BINDING         394
FT                   /ligand="thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:305790"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        97
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        163
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        251
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   411 AA;  46017 MW;  8823B56DA8386AC2 CRC64;
     MPLFSLVLLI LGLHCAPPNS CEGKITSCLS PQQNATLYKM SSINADFAFN LYRRFTVEIP
     DQNIFFSPVS IPAGLAMLSL GACSSTQTQI LEGLGFNLTD TPVAEIQQGF QHLICSLNFP
     KKELELQMGN ALFIGKQLKP LEKFLDDVKN LYETEVFSTD FSNVSAAQQE INSHVEKQTK
     GKIVGLIQDL KPNTITVLVN YLCFKAQWAN PFDPSKTEEG SSFLVDKTTT VQVPMMHQME
     QYYHLVDTEL NCTVLQMDYS KNALALFVLP KEGQMEWVEG AMSSKTLKKW NRLLRKGWVD
     LFVPKFSISA TYDLGDILLK MGIQDAFADN ADFSGLTKDN GLKVSNVAHK AMFYIGEKGT
     EAVPEVRFLN QPETTLLHPI IQFDRSFLLL ILEKNTRSIL FLGKVVDPTE A