ID   THBG_MOUSE              Reviewed;         418 AA.
AC   P61939; A2RSG7;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Thyroxine-binding globulin;
DE   AltName: Full=Serpin A7;
DE   AltName: Full=T4-binding globulin;
DE   Flags: Precursor;
GN   Name=Serpina7; Synonyms=Tbg;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Liver;
RA   Moeller L.C., Liao X., Dumitrescu A.M., Rietz C., Weiss R.E., Janssen O.E.,
RA   Refetoff S.;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Major thyroid hormone transport protein in serum.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR   EMBL; AY575783; AAS88726.1; -; mRNA.
DR   EMBL; BC132100; AAI32101.1; -; mRNA.
DR   RefSeq; XP_006528641.1; XM_006528578.3.
DR   AlphaFoldDB; P61939; -.
DR   SMR; P61939; -.
DR   BioGRID; 237113; 3.
DR   STRING; 10090.ENSMUSP00000033626; -.
DR   MEROPS; I04.955; -.
DR   GlyGen; P61939; 6 sites.
DR   iPTMnet; P61939; -.
DR   PhosphoSitePlus; P61939; -.
DR   CPTAC; non-CPTAC-3620; -.
DR   MaxQB; P61939; -.
DR   PaxDb; P61939; -.
DR   PeptideAtlas; P61939; -.
DR   PRIDE; P61939; -.
DR   ProteomicsDB; 262774; -.
DR   DNASU; 331535; -.
DR   GeneID; 331535; -.
DR   UCSC; uc009uka.2; mouse.
DR   CTD; 6906; -.
DR   MGI; MGI:3041197; Serpina7.
DR   eggNOG; KOG2392; Eukaryota.
DR   InParanoid; P61939; -.
DR   OrthoDB; 1124079at2759; -.
DR   BioGRID-ORCS; 331535; 1 hit in 73 CRISPR screens.
DR   PRO; PR:P61939; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P61939; protein.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0042562; F:hormone binding; ISO:MGI.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0009791; P:post-embryonic development; ISO:MGI.
DR   GO; GO:0033189; P:response to vitamin A; ISO:MGI.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; ISO:MGI.
DR   GO; GO:0070327; P:thyroid hormone transport; ISO:MGI.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..418
FT                   /note="Thyroxine-binding globulin"
FT                   /id="PRO_0000032437"
FT   BINDING         296
FT                   /ligand="thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:305790"
FT                   /evidence="ECO:0000250"
FT   BINDING         401
FT                   /ligand="thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:305790"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        24
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        168
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        227
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        256
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   418 AA;  47052 MW;  F1BE953FA206FD72 CRC64;
     MSVFFYLFVL VFGLQATIHC APHNSSEGKV TTCHLPQQNA TLYKMPSINA DFAFSLYRRL
     SVENPDLNIF FSPVSISVAL AMLSFGSGSS TQTQILEVLG FNLTDTPVTE LQQGFQHLIC
     SLNFPKNELE LQMGNAVFIG QQLKPLAKFL DDVKTLYETE VFSTDFSNVS AAQHKINSYV
     EKQTKGKIVG LIQGLKLNII MILVNYIHFR AQWANPFRVS KTEESSNFSV DKSTTVQVPM
     MHQLEQYYHY VDMELNCTVL QMDYSENALA LFVLPKEGHM EWVEAAMSSK TLKKWNYLLQ
     KGWVELFVPK FSISATYDLG STLQKMGMRD AFAESADFPG ITEDSGLKLS YAFHKAVLHI
     GEEGTKEGAS PEVGSLDQQE VPPLHPVIRL DRAFLLMILE KRTRSVLFLG KLVNPTKQ