THBG_PANTR
ID THBG_PANTR Reviewed; 415 AA.
AC P61640;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Thyroxine-binding globulin;
DE AltName: Full=Serpin A7;
DE AltName: Full=T4-binding globulin;
DE Flags: Precursor;
GN Name=SERPINA7; Synonyms=TBG;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Wissmann A., Fingerhut A., Mann K., Janssen O.E.;
RT "Characterization and primary structure of chimpanzee thyroxine-binding
RT globulin.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Major thyroid hormone transport protein in serum.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR EMBL; AY571782; AAS77608.1; -; Genomic_DNA.
DR RefSeq; NP_001009109.1; NM_001009109.1.
DR AlphaFoldDB; P61640; -.
DR SMR; P61640; -.
DR STRING; 9598.ENSPTRP00000038088; -.
DR MEROPS; I04.955; -.
DR PaxDb; P61640; -.
DR Ensembl; ENSPTRT00000041232; ENSPTRP00000038088; ENSPTRG00000022145.
DR GeneID; 465791; -.
DR KEGG; ptr:465791; -.
DR CTD; 6906; -.
DR VGNC; VGNC:10180; SERPINA7.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000161113; -.
DR HOGENOM; CLU_023330_2_1_1; -.
DR InParanoid; P61640; -.
DR OMA; CFKAQWA; -.
DR OrthoDB; 1124079at2759; -.
DR TreeFam; TF343201; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000022145; Expressed in liver.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR GO; GO:0070327; P:thyroid hormone transport; IEA:Ensembl.
DR Gene3D; 2.30.39.10; -; 1.
DR Gene3D; 3.30.497.10; -; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; PTHR11461; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; SSF56574; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..415
FT /note="Thyroxine-binding globulin"
FT /id="PRO_0000032438"
FT BINDING 293
FT /ligand="thyroxine"
FT /ligand_id="ChEBI:CHEBI:305790"
FT /evidence="ECO:0000250"
FT BINDING 398
FT /ligand="thyroxine"
FT /ligand_id="ChEBI:CHEBI:305790"
FT /evidence="ECO:0000250"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 253
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 415 AA; 46325 MW; 8B24EF8C720F8F0A CRC64;
MSPFLYLVLL VLGLHATIHC ASPEGKVTAC HSSQPNATLY KMSSINADFA FNLYRRFTVE
TPDKNIFFSP VSISAALVML SFGACCSTQT EIVETLGFNL TDTPMVEIQH GFQHLICSLN
FPKKELELQI GNALFIGKHL KPLAKFLNDV KTLYETEVFS TDFSNISAAK QEINSHVEMQ
TKGKVVGLIQ DLKPNTIMVL VNYIHFKAQW ANPFDPSKTE DSSSFLIDKT TTVQVPMMHQ
MEQYYHLVDM ELNCTVLQMD YSKNALALFV LPKEGQMESV EAAMSSKTLK KWNRLLQKGW
VDLFVPKFSI SATYDLGATL LKMGIQHAYS ENADFSGLTE DNGLKLSNAA HKAVLHIGEK
GTEAAAVPEV ELSDQPENTF LHPIIQIDRS FMLLILERST RSILFLGKVV DPTEA
