ID   THBG_SHEEP              Reviewed;         412 AA.
AC   P50450;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Thyroxine-binding globulin;
DE   AltName: Full=Serpin A7;
DE   AltName: Full=T4-binding globulin;
DE   Flags: Precursor;
GN   Name=SERPINA7; Synonyms=TBG;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=8143919; DOI=10.1016/0303-7207(93)90241-b;
RA   Tsykin A., Schreiber G.;
RT   "Sheep thyroxine-binding globulin: cDNA sequence and expression.";
RL   Mol. Cell. Endocrinol. 98:91-97(1993).
CC   -!- FUNCTION: Major thyroid hormone transport protein in serum.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR   EMBL; X69795; CAA49450.1; -; mRNA.
DR   PIR; I46421; I46421.
DR   RefSeq; NP_001094390.1; NM_001100920.2.
DR   AlphaFoldDB; P50450; -.
DR   SMR; P50450; -.
DR   STRING; 9940.ENSOARP00000000857; -.
DR   MEROPS; I04.955; -.
DR   GeneID; 443462; -.
DR   KEGG; oas:443462; -.
DR   CTD; 6906; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..412
FT                   /note="Thyroxine-binding globulin"
FT                   /id="PRO_0000032441"
FT   BINDING         292
FT                   /ligand="thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:305790"
FT                   /evidence="ECO:0000250"
FT   BINDING         395
FT                   /ligand="thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:305790"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        35
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        98
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        252
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   412 AA;  45948 MW;  E420D3530D1A04D9 CRC64;
     MPLFFSLVLL ILGLHCAPPN SCEGKITSCL SPQQNATLYK MSSINADFAF NLYRKVTVET
     PDQNIFFSPV SISAGLAMLS LGACSSTQTQ ILESLGFNLT DTPMAEIQQG FQHLICSLNF
     PKKELELQMG NALFIGKQLK PLEKFLDDVK NLYETEVFST DFSNVSAAQQ EINSHVERQT
     KGKIVGLIQD LKPNTITVLV NYLCFKAQWA NPFDPSKTEE GSSFLVDKTT TVQVPMMHQV
     DQYYHLVDTE LNCTVLQMDY SKNALALFVL PKEGQMEGVE GAMSSKILKK WNRLLQKGWV
     NLFVPKFSIS ATYDLGGILL KMGIQDAFAD NADFSGLTKD NGLKVSNVAH KAMFYIGEKG
     TEAIPEVRFL NQPETTLLHP IIQFDRSFLL LILEKNTRSI LFLGKVVDPT EV