THBI_BOTJA
ID THBI_BOTJA Reviewed; 15 AA.
AC P84026;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 02-JUN-2021, entry version 31.
DE RecName: Full=Thrombin inhibitor subunit 1;
DE AltName: Full=Thrombin inhibitor subunit I;
DE Flags: Fragment;
OS Bothrops jararaca (Jararaca) (Bothrops jajaraca).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX NCBI_TaxID=8724;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP SUBUNIT, AND GLYCOSYLATION.
RC TISSUE=Plasma {ECO:0000269|PubMed:12927776};
RX PubMed=12927776; DOI=10.1016/s0006-291x(03)01464-5;
RA Tanaka-Azevedo A.M., Tanaka A.S., Sano-Martins I.S.;
RT "A new blood coagulation inhibitor from the snake Bothrops jararaca plasma:
RT isolation and characterization.";
RL Biochem. Biophys. Res. Commun. 308:706-712(2003).
CC -!- FUNCTION: Binds to thrombin and inhibits blood coagulant activity. Does
CC not inhibit the serine protease activity of thrombin or platelet
CC aggregation activity. May bind to the heparin recognition exosite.
CC {ECO:0000269|PubMed:12927776, ECO:0000303|PubMed:12927776}.
CC -!- SUBUNIT: Heteromer of subunit I and subunit II.
CC {ECO:0000269|PubMed:12927776}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12927776}.
CC -!- TISSUE SPECIFICITY: Plasma. {ECO:0000269|PubMed:12927776}.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:12927776}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Blood coagulation cascade inhibiting toxin; Direct protein sequencing;
KW Glycoprotein; Hemostasis impairing toxin; Secreted; Toxin.
FT CHAIN <1..15
FT /note="Thrombin inhibitor subunit 1"
FT /id="PRO_0000072512"
FT NON_TER 1
FT /evidence="ECO:0000303|PubMed:12927776"
SQ SEQUENCE 15 AA; 1652 MW; CE8E339D80419137 CRC64;
EKFPAVNQKP QAAXL