BRK10_ASCTR
ID BRK10_ASCTR Reviewed; 10 AA.
AC P84832;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 07-APR-2021, entry version 24.
DE RecName: Full=Bradykinin-like peptide AR-10;
OS Ascaphus truei (Coastal tailed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Ascaphidae; Ascaphus.
OX NCBI_TaxID=8439;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP MASS SPECTROMETRY.
RC TISSUE=Skin secretion {ECO:0000269|PubMed:15922344};
RX PubMed=15922344; DOI=10.1016/j.ygcen.2005.04.006;
RA Conlon J.M., Jouenne T., Cosette P., Cosquer D., Vaudry H., Taylor C.K.,
RA Abel P.W.;
RT "Bradykinin-related peptides and tryptophyllins in the skin secretions of
RT the most primitive extant frog, Ascaphus truei.";
RL Gen. Comp. Endocrinol. 143:193-199(2005).
CC -!- FUNCTION: Induces relaxation of mouse trachea that has been
CC precontracted with methacholine. May induce relaxation of arterial
CC smooth muscle. May target bradykinin receptors (BDKRB).
CC {ECO:0000269|PubMed:15922344}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15922344}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000269|PubMed:15922344}.
CC -!- MASS SPECTROMETRY: Mass=1039.6; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:15922344};
CC -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IDA:UniProtKB.
DR GO; GO:0006952; P:defense response; IDA:UniProtKB.
DR GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Direct protein sequencing;
KW G-protein coupled receptor impairing toxin; Secreted; Toxin; Vasoactive;
KW Vasodilator.
FT PEPTIDE 1..10
FT /note="Bradykinin-like peptide AR-10"
FT /evidence="ECO:0000269|PubMed:15922344"
FT /id="PRO_0000233936"
SQ SEQUENCE 10 AA; 1040 MW; DF49D275B7286772 CRC64;
APVPGLSPFR