ID   THB_ENTTH               Reviewed;          86 AA.
AC   C0HLR2;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   12-AUG-2020, sequence version 1.
DT   25-MAY-2022, entry version 4.
DE   RecName: Full=Bacteriocin thailandicin;
OS   Enterococcus thailandicus.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=417368;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND FUNCTION.
RA   Al-Madboly L., El-Deeb N., Ragab A., Kabbash A., Kenawy A.;
RT   "Purification and characterization of a hepatotoxic bacteriocin from
RT   Enterococcus thailandicus as a potential natural anticancer substance.";
RL   Submitted (FEB-2020) to UniProtKB.
CC   -!- FUNCTION: Cyclopeptide antibiotic with bacteriolytic activity against
CC       the Gram-positive bacteria S.aureus and S.thermophilus, and lower
CC       activity against the Gram-negative bacteria E.coli and P.aeruginosa.
CC       {ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   AlphaFoldDB; C0HLR2; -.
DR   SMR; C0HLR2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.225.10; -; 1.
DR   InterPro; IPR009086; Bacteriocin_AS48.
DR   InterPro; IPR020038; Circ_bacteriocin.
DR   Pfam; PF09221; Bacteriocin_IId; 1.
DR   TIGRFAMs; TIGR03651; circ_ocin_uber; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Secreted.
FT   CHAIN           1..86
FT                   /note="Bacteriocin thailandicin"
FT                   /id="PRO_0000450686"
FT   CROSSLNK        23..86
FT                   /note="Cyclopeptide (Leu-Trp)"
FT                   /evidence="ECO:0000250|UniProtKB:A5H1G9"
SQ   SEQUENCE   86 AA;  8633 MW;  ED95E542DC6DE012 CRC64;
     KKNMLLVNPI VGIGGLFVGA PMLTANLGIS SYAAKKVIDD INTGSAVATI IALVTAVVGG
     GLITAGIVAT TKSLIKKYGA KYSAAW